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Q542P9 (Q542P9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Ppara EMBL EDL04427.1 MGI 104740
ORF Names:mCG_13586 EMBL EDL04427.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains nuclear receptor DNA-binding domain. SAAS SAAS008946

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS008946 RuleBase RU004334
   Cellular componentNucleus SAAS SAAS008946 RuleBase RU004334
   DomainZinc-finger SAAS SAAS008946 RuleBase RU004334
   LigandDNA-binding SAAS SAAS008946 RuleBase RU004334
Metal-binding
Zinc
   Molecular functionReceptor RuleBase RU004334 EMBL EDL04427.1
Gene Ontology (GO)
   Biological_processbehavioral response to nicotine

Inferred from electronic annotation. Source: Ensembl

enamel mineralization

Inferred from mutant phenotype PubMed 19320717. Source: MGI

epidermis development

Inferred from mutant phenotype PubMed 12485431. Source: MGI

fatty acid metabolic process

Inferred from mutant phenotype PubMed 15007068. Source: MGI

glucose metabolic process

Traceable author statement PubMed 10377439. Source: MGI

heart development

Inferred from electronic annotation. Source: Ensembl

lipid metabolic process

Traceable author statement PubMed 10377439. Source: MGI

lipoprotein metabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of cholesterol storage

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron death

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

negative regulation of receptor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequestering of triglyceride

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

positive regulation of gluconeogenesis

Inferred from mutant phenotype PubMed 15232616. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16571721PubMed 20385772PubMed 8041794. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 15007068. Source: MGI

regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of fatty acid metabolic process

Inferred from mutant phenotype PubMed 9488698. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 15313227. Source: MGI

regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Traceable author statement PubMed 10377439. Source: MGI

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to insulin

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from mutant phenotype PubMed 11514592. Source: MGI

   Cellular_componentnucleus

Traceable author statement PubMed 10377439. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12015306PubMed 15232616PubMed 15237213. Source: MGI

RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription

Inferred from direct assay PubMed 15232616. Source: MGI

drug binding

Inferred from electronic annotation. Source: Ensembl

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from electronic annotation. Source: Ensembl

receptor activity

Inferred from direct assay PubMed 12802337. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

steroid hormone receptor activity

Traceable author statement PubMed 10377439. Source: MGI

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q542P9 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 2930A5191C610B6B

FASTA46852,347
        10         20         30         40         50         60 
MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEESSGSFG FADYQYLGSC 

        70         80         90        100        110        120 
PGSEGSVITD TLSPASSPSS VSCPVIPAST DESPGSALNI ECRICGDKAS GYHYGVHACE 

       130        140        150        160        170        180 
GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE 

       190        200        210        220        230        240 
KAKLKAEILT CEHDLKDSET ADLKSLGKRI HEAYLKNFNM NKVKARVILA GKTSNNPPFV 

       250        260        270        280        290        300 
IHDMETLCMA EKTLVAKMVA NGVEDKEAEV RFFHCCQCMS VETVTELTEF AKAIPGFANL 

       310        320        330        340        350        360 
DLNDQVTLLK YGVYEAIFTM LSSLMNKDGM LIAYGNGFIT REFLKNLRKP FCDIMEPKFD 

       370        380        390        400        410        420 
FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIGYIEKL QEGIVHVLKL HLQSNHPDDT 

       430        440        450        460 
FLFPKLLQKM VDLRQLVTEH AQLVQVIKKT ESDAALHPLL QEIYRDMY 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38303.1.
Tissue: Head EMBL BAC38303.1, Liver EMBL BAE28893.1 and Urinary bladder EMBL BAC29149.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38303.1.
Tissue: Head EMBL BAC38303.1, Liver EMBL BAE28893.1 and Urinary bladder EMBL BAC29149.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38303.1.
Tissue: Head EMBL BAC38303.1, Liver EMBL BAE28893.1 and Urinary bladder EMBL BAC29149.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38303.1.
Tissue: Head EMBL BAC38303.1, Liver EMBL BAE28893.1 and Urinary bladder EMBL BAC29149.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC29149.1.
Tissue: Urinary bladder EMBL BAC29149.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38303.1.
Tissue: Head EMBL BAC38303.1, Liver EMBL BAE28893.1 and Urinary bladder EMBL BAC29149.1.
[7]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL04427.1.
[8]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38303.1.
Tissue: Head EMBL BAC38303.1.
[9]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE28893.1.
Tissue: Liver EMBL BAE28893.1.
[10]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38303.1.
Tissue: Head EMBL BAC38303.1, Liver EMBL BAE28893.1 and Urinary bladder EMBL BAC29149.1.
[11]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC38303.1.
Tissue: Head EMBL BAC38303.1, Liver EMBL BAE28893.1 and Urinary bladder EMBL BAC29149.1.
[12]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL04427.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK035676 mRNA. Translation: BAC29149.1.
AK081709 mRNA. Translation: BAC38303.1.
AK149460 mRNA. Translation: BAE28893.1.
CH466550 Genomic DNA. Translation: EDL04427.1.
RefSeqNP_001106889.1. NM_001113418.1.
NP_035274.2. NM_011144.6.
XP_006520682.1. XM_006520619.1.
XP_006520683.1. XM_006520620.1.
XP_006520684.1. XM_006520621.1.
XP_006520685.1. XM_006520622.1.
XP_006520686.1. XM_006520623.1.
UniGeneMm.212789.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19013.
KEGGmmu:19013.

Organism-specific databases

CTD5465.
MGIMGI:104740. Ppara.

Phylogenomic databases

GeneTreeENSGT00740000115076.
HOVERGENHBG106004.
InParanoidQ542P9.
KOK07294.
OMATESPICP.

Gene expression databases

GenevestigatorQ542P9.

Family and domain databases

Gene3D1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProIPR003074. 1Cnucl_rcpt.
IPR003076. 1Cnucl_rcpt_A.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01288. PROXISOMEPAR.
PR01289. PROXISOMPAAR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295428.
SOURCESearch...

Entry information

Entry nameQ542P9_MOUSE
AccessionPrimary (citable) accession number: Q542P9
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)