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Q542P9

- Q542P9_MOUSE

UniProt

Q542P9 - Q542P9_MOUSE

Protein
Submitted name:

Peroxisome proliferator activated receptor alpha, isoform CRA_a

Gene

Ppara

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. drug binding Source: Ensembl
    3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
    4. protein binding Source: MGI
    5. receptor activity Source: MGI
    6. RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: MGI
    7. sequence-specific DNA binding Source: InterPro
    8. steroid hormone receptor activity Source: MGI
    9. zinc ion binding Source: InterPro

    GO - Biological processi

    1. behavioral response to nicotine Source: Ensembl
    2. enamel mineralization Source: MGI
    3. epidermis development Source: MGI
    4. fatty acid metabolic process Source: MGI
    5. glucose metabolic process Source: MGI
    6. heart development Source: Ensembl
    7. lipid metabolic process Source: MGI
    8. lipoprotein metabolic process Source: Ensembl
    9. negative regulation of blood pressure Source: Ensembl
    10. negative regulation of cholesterol storage Source: Ensembl
    11. negative regulation of neuron death Source: Ensembl
    12. negative regulation of protein binding Source: Ensembl
    13. negative regulation of receptor biosynthetic process Source: Ensembl
    14. negative regulation of sequestering of triglyceride Source: Ensembl
    15. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. negative regulation of transcription regulatory region DNA binding Source: Ensembl
    17. positive regulation of gluconeogenesis Source: MGI
    18. positive regulation of transcription, DNA-templated Source: MGI
    19. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    20. regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    21. regulation of fatty acid metabolic process Source: MGI
    22. regulation of gene expression Source: MGI
    23. regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    25. regulation of transcription, DNA-templated Source: MGI
    26. response to hypoxia Source: Ensembl
    27. response to insulin Source: Ensembl
    28. wound healing Source: MGI

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peroxisome proliferator activated receptor alpha, isoform CRA_aImported
    Gene namesi
    Name:PparaImported
    ORF Names:mCG_13586Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:104740. Ppara.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ542P9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115076.
    HOVERGENiHBG106004.
    InParanoidiQ542P9.
    KOiK07294.
    OMAiTESPICP.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR003074. 1Cnucl_rcpt.
    IPR003076. 1Cnucl_rcpt_A.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01288. PROXISOMEPAR.
    PR01289. PROXISOMPAAR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q542P9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEESSGSFG    50
    FADYQYLGSC PGSEGSVITD TLSPASSPSS VSCPVIPAST DESPGSALNI 100
    ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR 150
    NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDLKDSET 200
    ADLKSLGKRI HEAYLKNFNM NKVKARVILA GKTSNNPPFV IHDMETLCMA 250
    EKTLVAKMVA NGVEDKEAEV RFFHCCQCMS VETVTELTEF AKAIPGFANL 300
    DLNDQVTLLK YGVYEAIFTM LSSLMNKDGM LIAYGNGFIT REFLKNLRKP 350
    FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIGYIEKL 400
    QEGIVHVLKL HLQSNHPDDT FLFPKLLQKM VDLRQLVTEH AQLVQVIKKT 450
    ESDAALHPLL QEIYRDMY 468
    Length:468
    Mass (Da):52,347
    Last modified:May 24, 2005 - v1
    Checksum:i2930A5191C610B6B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK035676 mRNA. Translation: BAC29149.1.
    AK081709 mRNA. Translation: BAC38303.1.
    AK149460 mRNA. Translation: BAE28893.1.
    CH466550 Genomic DNA. Translation: EDL04427.1.
    RefSeqiNP_001106889.1. NM_001113418.1.
    NP_035274.2. NM_011144.6.
    XP_006520682.1. XM_006520619.1.
    XP_006520683.1. XM_006520620.1.
    XP_006520684.1. XM_006520621.1.
    XP_006520685.1. XM_006520622.1.
    XP_006520686.1. XM_006520623.1.
    UniGeneiMm.212789.

    Genome annotation databases

    GeneIDi19013.
    KEGGimmu:19013.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK035676 mRNA. Translation: BAC29149.1 .
    AK081709 mRNA. Translation: BAC38303.1 .
    AK149460 mRNA. Translation: BAE28893.1 .
    CH466550 Genomic DNA. Translation: EDL04427.1 .
    RefSeqi NP_001106889.1. NM_001113418.1.
    NP_035274.2. NM_011144.6.
    XP_006520682.1. XM_006520619.1.
    XP_006520683.1. XM_006520620.1.
    XP_006520684.1. XM_006520621.1.
    XP_006520685.1. XM_006520622.1.
    XP_006520686.1. XM_006520623.1.
    UniGenei Mm.212789.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 19013.
    KEGGi mmu:19013.

    Organism-specific databases

    CTDi 5465.
    MGIi MGI:104740. Ppara.

    Phylogenomic databases

    GeneTreei ENSGT00740000115076.
    HOVERGENi HBG106004.
    InParanoidi Q542P9.
    KOi K07294.
    OMAi TESPICP.

    Miscellaneous databases

    NextBioi 295428.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q542P9.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR003074. 1Cnucl_rcpt.
    IPR003076. 1Cnucl_rcpt_A.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01288. PROXISOMEPAR.
    PR01289. PROXISOMPAAR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported, LiverImported and Urinary bladderImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported, LiverImported and Urinary bladderImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported, LiverImported and Urinary bladderImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported, LiverImported and Urinary bladderImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Urinary bladderImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported, LiverImported and Urinary bladderImported.
    7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LiverImported.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported, LiverImported and Urinary bladderImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported, LiverImported and Urinary bladderImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ542P9_MOUSE
    AccessioniPrimary (citable) accession number: Q542P9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)