ID   Q542M5_MOUSE            Unreviewed;       316 AA.
AC   Q542M5;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   24-JAN-2024, entry version 149.
DE   RecName: Full=Galectin {ECO:0000256|RuleBase:RU102079};
GN   Name=Lgals8 {ECO:0000313|MGI:MGI:1928481};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC38880.1};
RN   [1] {ECO:0000313|EMBL:BAC38880.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38880.1};
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAE27406.1}, Lung
RC   {ECO:0000313|EMBL:BAB23560.1}, Placenta {ECO:0000313|EMBL:BAE26721.1},
RC   and Thymus {ECO:0000313|EMBL:BAC38880.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAC38880.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38880.1};
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAE27406.1}, Lung
RC   {ECO:0000313|EMBL:BAB23560.1}, Placenta {ECO:0000313|EMBL:BAE26721.1},
RC   and Thymus {ECO:0000313|EMBL:BAC38880.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAC38880.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38880.1};
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAE27406.1}, Lung
RC   {ECO:0000313|EMBL:BAB23560.1}, Placenta {ECO:0000313|EMBL:BAE26721.1},
RC   and Thymus {ECO:0000313|EMBL:BAC38880.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAB23560.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB23560.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:BAB23560.1};
RA   Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T.,
RA   Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T.,
RA   Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y.,
RA   Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A.,
RA   Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C.,
RA   Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K.,
RA   Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M.,
RA   Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T.,
RA   Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.;
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:BAC38880.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38880.1};
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAE27406.1}, Lung
RC   {ECO:0000313|EMBL:BAB23560.1}, Placenta {ECO:0000313|EMBL:BAE26721.1},
RC   and Thymus {ECO:0000313|EMBL:BAC38880.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [6] {ECO:0000313|EMBL:BAC38880.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38880.1};
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAE27406.1}, Lung
RC   {ECO:0000313|EMBL:BAB23560.1}, Placenta {ECO:0000313|EMBL:BAE26721.1},
RC   and Thymus {ECO:0000313|EMBL:BAC38880.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [7] {ECO:0000313|EMBL:BAC38880.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38880.1};
RC   TISSUE=Thymus {ECO:0000313|EMBL:BAC38880.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA   Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA   Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA   Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA   Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA   Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA   Hayashizaki Y.;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:BAE26721.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE26721.1};
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAE27406.1}, and Placenta
RC   {ECO:0000313|EMBL:BAE26721.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA   Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA   Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA   Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA   Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:BAC38880.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38880.1};
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAE27406.1}, Lung
RC   {ECO:0000313|EMBL:BAB23560.1}, Placenta {ECO:0000313|EMBL:BAE26721.1},
RC   and Thymus {ECO:0000313|EMBL:BAC38880.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [10] {ECO:0000313|EMBL:BAC38880.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38880.1};
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAE27406.1}, Lung
RC   {ECO:0000313|EMBL:BAB23560.1}, Placenta {ECO:0000313|EMBL:BAE26721.1},
RC   and Thymus {ECO:0000313|EMBL:BAC38880.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [11] {ECO:0000313|EMBL:CAJ18459.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J.,
RA   Wiemann S., Schick M., Korn B.;
RT   "Cloning of mouse full open reading frames in Gateway(R) system entry
RT   vector (pDONR201).";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
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DR   EMBL; AK004782; BAB23560.1; -; mRNA.
DR   EMBL; AK083350; BAC38880.1; -; mRNA.
DR   EMBL; AK145881; BAE26721.1; -; mRNA.
DR   EMBL; AK146746; BAE27406.1; -; mRNA.
DR   EMBL; CT010251; CAJ18459.1; -; mRNA.
DR   RefSeq; NP_001185972.1; NM_001199043.1.
DR   RefSeq; NP_001277984.1; NM_001291055.1.
DR   RefSeq; NP_001277986.1; NM_001291057.1.
DR   RefSeq; NP_001277989.1; NM_001291060.1.
DR   RefSeq; NP_061374.1; NM_018886.5.
DR   RefSeq; XP_006516777.1; XM_006516714.2.
DR   RefSeq; XP_006516778.1; XM_006516715.2.
DR   AlphaFoldDB; Q542M5; -.
DR   SMR; Q542M5; -.
DR   Antibodypedia; 34699; 453 antibodies from 36 providers.
DR   DNASU; 56048; -.
DR   GeneID; 56048; -.
DR   KEGG; mmu:56048; -.
DR   AGR; MGI:1928481; -.
DR   CTD; 3964; -.
DR   MGI; MGI:1928481; Lgals8.
DR   VEuPathDB; HostDB:ENSMUSG00000057554; -.
DR   HOGENOM; CLU_037794_1_0_1; -.
DR   OrthoDB; 3891658at2759; -.
DR   BioGRID-ORCS; 56048; 3 hits in 77 CRISPR screens.
DR   ChiTaRS; Lgals8; mouse.
DR   ExpressionAtlas; Q542M5; baseline and differential.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-UniRule.
DR   CDD; cd00070; GLECT; 2.
DR   Gene3D; 2.60.120.200; -; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; GALECTIN; 1.
DR   PANTHER; PTHR11346:SF22; GALECTIN-8; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 2.
DR   SMART; SM00908; Gal-bind_lectin; 2.
DR   SMART; SM00276; GLECT; 2.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR   PROSITE; PS51304; GALECTIN; 2.
PE   1: Evidence at protein level;
KW   Lectin {ECO:0000256|RuleBase:RU102079}.
FT   DOMAIN          18..151
FT                   /note="Galectin"
FT                   /evidence="ECO:0000259|PROSITE:PS51304"
FT   DOMAIN          186..316
FT                   /note="Galectin"
FT                   /evidence="ECO:0000259|PROSITE:PS51304"
SQ   SEQUENCE   316 AA;  36162 MW;  11A20309AEF52C69 CRC64;
     MLSLNNLQNI IYNPIIPYVG TITEQLKPGS LIVIRGHVPK DSERFQVDFQ LGNSLKPRAD
     VAFHFNPRFK RSSCIVCNTL TQEKWGWEEI TYDMPFRKEK SFEIVFMVLK NKFQVAVNGR
     HVLLYAHRIS PEQIDTVGIY GKVNIHSIGF RFSSDLQSME TSALGLTQIN RENIQKPGKL
     QLSLPFEARL NASMGPGRTV VIKGEVNTNA RSFNVDLVAG KTRDIALHLN PRLNVKAFVR
     NSFLQDAWGE EERNITCFPF SSGMYFEMII YCDVREFKVA INGVHSLEYK HRFKDLSSID
     TLSVDGDIRL LDVRSW
//