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Protein

Galectin

Gene

Lgals8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: MGI

GO - Biological processi

  1. plasma cell differentiation Source: MGI
  2. T cell costimulation Source: MGI
Complete GO annotation...

Keywords - Ligandi

LectinUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GalectinUniRule annotation
Gene namesi
Name:Lgals8Imported
ORF Names:mCG_9125Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1928481. Lgals8.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ542M5.

Structurei

3D structure databases

ProteinModelPortaliQ542M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 galectin domains.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000290194.
HOVERGENiHBG002412.
KOiK06832.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q542M5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSLNNLQNI IYNPIIPYVG TITEQLKPGS LIVIRGHVPK DSERFQVDFQ
60 70 80 90 100
LGNSLKPRAD VAFHFNPRFK RSSCIVCNTL TQEKWGWEEI TYDMPFRKEK
110 120 130 140 150
SFEIVFMVLK NKFQVAVNGR HVLLYAHRIS PEQIDTVGIY GKVNIHSIGF
160 170 180 190 200
RFSSDLQSME TSALGLTQIN RENIQKPGKL QLSLPFEARL NASMGPGRTV
210 220 230 240 250
VIKGEVNTNA RSFNVDLVAG KTRDIALHLN PRLNVKAFVR NSFLQDAWGE
260 270 280 290 300
EERNITCFPF SSGMYFEMII YCDVREFKVA INGVHSLEYK HRFKDLSSID
310
TLSVDGDIRL LDVRSW
Length:316
Mass (Da):36,162
Last modified:May 24, 2005 - v1
Checksum:i11A20309AEF52C69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004782 mRNA. Translation: BAB23560.1.
AK083350 mRNA. Translation: BAC38880.1.
AK145881 mRNA. Translation: BAE26721.1.
AK146746 mRNA. Translation: BAE27406.1.
CT010251 mRNA. Translation: CAJ18459.1.
CH466588 Genomic DNA. Translation: EDL32308.1.
CH466588 Genomic DNA. Translation: EDL32309.1.
CH466588 Genomic DNA. Translation: EDL32310.1.
CH466588 Genomic DNA. Translation: EDL32312.1.
RefSeqiNP_001185972.1. NM_001199043.1.
NP_001277984.1. NM_001291055.1.
NP_001277986.1. NM_001291057.1.
NP_001277989.1. NM_001291060.1.
NP_061374.1. NM_018886.5.
XP_006516777.1. XM_006516714.1.
XP_006516778.1. XM_006516715.1.
UniGeneiMm.474138.
Mm.486765.

Genome annotation databases

GeneIDi56048.
KEGGimmu:56048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004782 mRNA. Translation: BAB23560.1.
AK083350 mRNA. Translation: BAC38880.1.
AK145881 mRNA. Translation: BAE26721.1.
AK146746 mRNA. Translation: BAE27406.1.
CT010251 mRNA. Translation: CAJ18459.1.
CH466588 Genomic DNA. Translation: EDL32308.1.
CH466588 Genomic DNA. Translation: EDL32309.1.
CH466588 Genomic DNA. Translation: EDL32310.1.
CH466588 Genomic DNA. Translation: EDL32312.1.
RefSeqiNP_001185972.1. NM_001199043.1.
NP_001277984.1. NM_001291055.1.
NP_001277986.1. NM_001291057.1.
NP_001277989.1. NM_001291060.1.
NP_061374.1. NM_018886.5.
XP_006516777.1. XM_006516714.1.
XP_006516778.1. XM_006516715.1.
UniGeneiMm.474138.
Mm.486765.

3D structure databases

ProteinModelPortaliQ542M5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56048.
KEGGimmu:56048.

Organism-specific databases

CTDi3964.
MGIiMGI:1928481. Lgals8.

Phylogenomic databases

HOGENOMiHOG000290194.
HOVERGENiHBG002412.
KOiK06832.

Miscellaneous databases

ChiTaRSiLgals8. mouse.
NextBioi311828.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ542M5.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported, LungImported, PlacentaImported and ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported, LungImported, PlacentaImported and ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported, LungImported, PlacentaImported and ThymusImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported, LungImported, PlacentaImported and ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported, LungImported, PlacentaImported and ThymusImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported and PlacentaImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported, LungImported, PlacentaImported and ThymusImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported, LungImported, PlacentaImported and ThymusImported.
  12. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  13. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ542M5_MOUSE
AccessioniPrimary (citable) accession number: Q542M5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: February 4, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.