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Protein
Submitted name:

Ceroid-lipofuscinosis, neuronal 8, isoform CRA_a

Gene

Cln8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ceroid-lipofuscinosis, neuronal 8, isoform CRA_aImported
Gene namesi
Name:Cln8Imported
ORF Names:mCG_14825Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1349447. Cln8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4220HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8423HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12118HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15119HelicalSequence analysisAdd
BLAST
Transmembranei157 – 18024HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22222HelicalSequence analysisAdd
BLAST
Transmembranei228 – 24922HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000026317.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027554.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 262201TLC (TRAM/LAG1/CLN8)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains TLC (TRAM/LAG1/CLN8) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4561. Eukaryota.
ENOG410XPW0. LUCA.
HOVERGENiHBG028338.
KOiK12360.
OMAiFHCRMVL.
OrthoDBiEOG091G0DG9.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q542J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPVSSHGLA ESIFDLDYAS WKIRSTLAVA GFVFYLGVFV VCHQLSSSLN
60 70 80 90 100
ATYRSLAAKE KVFWNLAATR AVFGVQSTTA GLWALLGDPV LYADKALGQQ
110 120 130 140 150
NWCWFHITTA TGFFFFENVA VHLSNLFFRT FDLFLVVHHL FAFLGFLGSA
160 170 180 190 200
INLRAGHYLA MTTLLLEMST PFTCISWMLL KAGWSDSLFW KANQWLMIHM
210 220 230 240 250
FHCRMILTYH MWWVCFCHWD ALTSSLHLPH WALFLFGLAL LTAVINPYWT
260 270 280
HKKTQQLLHP VDWNFAQEEA KGSRQERTNG QVPRKKRL
Length:288
Mass (Da):33,109
Last modified:May 24, 2005 - v1
Checksum:iA11225DE3CD7DEA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049145 mRNA. Translation: BAC33570.1.
AK088300 mRNA. Translation: BAC40269.1.
AK089692 mRNA. Translation: BAC40944.1.
AK164268 mRNA. Translation: BAE37712.1.
AK166905 mRNA. Translation: BAE39107.1.
AK169698 mRNA. Translation: BAE41313.1.
AK171446 mRNA. Translation: BAE42456.1.
CH466566 Genomic DNA. Translation: EDL22189.1.
CH466566 Genomic DNA. Translation: EDL22190.1.
CH466566 Genomic DNA. Translation: EDL22191.1.
CH466566 Genomic DNA. Translation: EDL22192.1.
RefSeqiNP_036130.1. NM_012000.3.
XP_006508869.1. XM_006508806.2.
XP_006508870.1. XM_006508807.2.
UniGeneiMm.254027.

Genome annotation databases

GeneIDi26889.
KEGGimmu:26889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049145 mRNA. Translation: BAC33570.1.
AK088300 mRNA. Translation: BAC40269.1.
AK089692 mRNA. Translation: BAC40944.1.
AK164268 mRNA. Translation: BAE37712.1.
AK166905 mRNA. Translation: BAE39107.1.
AK169698 mRNA. Translation: BAE41313.1.
AK171446 mRNA. Translation: BAE42456.1.
CH466566 Genomic DNA. Translation: EDL22189.1.
CH466566 Genomic DNA. Translation: EDL22190.1.
CH466566 Genomic DNA. Translation: EDL22191.1.
CH466566 Genomic DNA. Translation: EDL22192.1.
RefSeqiNP_036130.1. NM_012000.3.
XP_006508869.1. XM_006508806.2.
XP_006508870.1. XM_006508807.2.
UniGeneiMm.254027.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26889.
KEGGimmu:26889.

Organism-specific databases

CTDi2055.
MGIiMGI:1349447. Cln8.

Phylogenomic databases

eggNOGiKOG4561. Eukaryota.
ENOG410XPW0. LUCA.
HOVERGENiHBG028338.
KOiK12360.
OMAiFHCRMVL.
OrthoDBiEOG091G0DG9.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026317.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ542J5_MOUSE
AccessioniPrimary (citable) accession number: Q542J5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.