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Q542J5

- Q542J5_MOUSE

UniProt

Q542J5 - Q542J5_MOUSE

Protein
Submitted name:

Ceroid-lipofuscinosis, neuronal 8, isoform CRA_a

Gene

Cln8

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. adult walking behavior Source: MGI
    3. age-dependent response to oxidative stress Source: MGI
    4. associative learning Source: MGI
    5. cellular macromolecule catabolic process Source: MGI
    6. cellular protein catabolic process Source: MGI
    7. cellular protein metabolic process Source: MGI
    8. ceramide metabolic process Source: Ensembl
    9. cholesterol metabolic process Source: Ensembl
    10. L-glutamate uptake involved in synaptic transmission Source: MGI
    11. lysosome organization Source: MGI
    12. mitochondrial membrane organization Source: MGI
    13. musculoskeletal movement Source: MGI
    14. negative regulation of apoptotic process Source: MGI
    15. negative regulation of transferase activity Source: MGI
    16. neurofilament cytoskeleton organization Source: MGI
    17. neuromuscular process controlling balance Source: MGI
    18. neuromuscular process controlling posture Source: MGI
    19. phospholipid metabolic process Source: MGI
    20. photoreceptor cell maintenance Source: MGI
    21. regulation of cell size Source: MGI
    22. retina development in camera-type eye Source: MGI
    23. social behavior Source: MGI
    24. somatic motor neuron differentiation Source: MGI
    25. spinal cord motor neuron differentiation Source: MGI
    26. visual perception Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ceroid-lipofuscinosis, neuronal 8, isoform CRA_aImported
    Gene namesi
    Name:Cln8Imported
    ORF Names:mCG_14825Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1349447. Cln8.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. mitochondrion Source: GOC

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ542J5.

    Family & Domainsi

    Sequence similaritiesi

    Contains TLC (TRAM/LAG1/CLN8) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG028338.
    InParanoidiQ542J5.
    KOiK12360.
    OMAiLTYHMWW.

    Family and domain databases

    InterProiIPR006634. TLC-dom.
    [Graphical view]
    PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view]
    SMARTiSM00724. TLC. 1 hit.
    [Graphical view]
    PROSITEiPS50922. TLC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q542J5-1 [UniParc]FASTAAdd to Basket

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    MTPVSSHGLA ESIFDLDYAS WKIRSTLAVA GFVFYLGVFV VCHQLSSSLN    50
    ATYRSLAAKE KVFWNLAATR AVFGVQSTTA GLWALLGDPV LYADKALGQQ 100
    NWCWFHITTA TGFFFFENVA VHLSNLFFRT FDLFLVVHHL FAFLGFLGSA 150
    INLRAGHYLA MTTLLLEMST PFTCISWMLL KAGWSDSLFW KANQWLMIHM 200
    FHCRMILTYH MWWVCFCHWD ALTSSLHLPH WALFLFGLAL LTAVINPYWT 250
    HKKTQQLLHP VDWNFAQEEA KGSRQERTNG QVPRKKRL 288
    Length:288
    Mass (Da):33,109
    Last modified:May 24, 2005 - v1
    Checksum:iA11225DE3CD7DEA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049145 mRNA. Translation: BAC33570.1.
    AK088300 mRNA. Translation: BAC40269.1.
    AK089692 mRNA. Translation: BAC40944.1.
    AK164268 mRNA. Translation: BAE37712.1.
    AK166905 mRNA. Translation: BAE39107.1.
    AK169698 mRNA. Translation: BAE41313.1.
    AK171446 mRNA. Translation: BAE42456.1.
    CH466566 Genomic DNA. Translation: EDL22189.1.
    CH466566 Genomic DNA. Translation: EDL22190.1.
    CH466566 Genomic DNA. Translation: EDL22191.1.
    CH466566 Genomic DNA. Translation: EDL22192.1.
    RefSeqiNP_036130.1. NM_012000.3.
    XP_006508869.1. XM_006508806.1.
    XP_006508870.1. XM_006508807.1.
    UniGeneiMm.254027.

    Genome annotation databases

    GeneIDi26889.
    KEGGimmu:26889.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049145 mRNA. Translation: BAC33570.1 .
    AK088300 mRNA. Translation: BAC40269.1 .
    AK089692 mRNA. Translation: BAC40944.1 .
    AK164268 mRNA. Translation: BAE37712.1 .
    AK166905 mRNA. Translation: BAE39107.1 .
    AK169698 mRNA. Translation: BAE41313.1 .
    AK171446 mRNA. Translation: BAE42456.1 .
    CH466566 Genomic DNA. Translation: EDL22189.1 .
    CH466566 Genomic DNA. Translation: EDL22190.1 .
    CH466566 Genomic DNA. Translation: EDL22191.1 .
    CH466566 Genomic DNA. Translation: EDL22192.1 .
    RefSeqi NP_036130.1. NM_012000.3.
    XP_006508869.1. XM_006508806.1.
    XP_006508870.1. XM_006508807.1.
    UniGenei Mm.254027.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 26889.
    KEGGi mmu:26889.

    Organism-specific databases

    CTDi 2055.
    MGIi MGI:1349447. Cln8.

    Phylogenomic databases

    HOVERGENi HBG028338.
    InParanoidi Q542J5.
    KOi K12360.
    OMAi LTYHMWW.

    Miscellaneous databases

    NextBioi 304715.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q542J5.

    Family and domain databases

    InterProi IPR006634. TLC-dom.
    [Graphical view ]
    Pfami PF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view ]
    SMARTi SM00724. TLC. 1 hit.
    [Graphical view ]
    PROSITEi PS50922. TLC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
    7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported and ThymusImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: ThymusImported and Whole bodyImported.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ542J5_MOUSE
    AccessioniPrimary (citable) accession number: Q542J5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)