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Q542J5 (Q542J5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Cln8 MGI 1349447 EMBL EDL22189.1
ORF Names:mCG_14825 EMBL EDL22189.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains TLC (TRAM/LAG1/CLN8) domain. SAAS SAAS006634

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS006634
Gene Ontology (GO)
   Biological_processL-glutamate uptake involved in synaptic transmission

Inferred from mutant phenotype PubMed 8095977PubMed 9600674. Source: MGI

adult locomotory behavior

Inferred from mutant phenotype PubMed 12020865. Source: MGI

adult walking behavior

Inferred from mutant phenotype PubMed 10215924PubMed 2061715PubMed 3783318PubMed 7668363PubMed 7683855PubMed 9918704. Source: MGI

age-dependent response to oxidative stress

Inferred from mutant phenotype PubMed 15213005. Source: MGI

associative learning

Inferred from mutant phenotype PubMed 15885820. Source: MGI

cellular macromolecule catabolic process

Inferred from mutant phenotype PubMed 15647513. Source: MGI

cellular protein catabolic process

Inferred from mutant phenotype PubMed 8389815. Source: MGI

cellular protein metabolic process

Inferred from mutant phenotype PubMed 1658691. Source: MGI

ceramide metabolic process

Inferred from electronic annotation. Source: Ensembl

cholesterol metabolic process

Inferred from electronic annotation. Source: Ensembl

lysosome organization

Inferred from mutant phenotype PubMed 10087069PubMed 7613514PubMed 8144516PubMed 8160780. Source: MGI

mitochondrial membrane organization

Inferred from mutant phenotype PubMed 9059519. Source: MGI

musculoskeletal movement

Inferred from mutant phenotype PubMed 2061715. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 15565184. Source: MGI

negative regulation of transferase activity

Inferred from mutant phenotype PubMed 8873145. Source: MGI

neurofilament cytoskeleton organization

Inferred from mutant phenotype PubMed 2061715. Source: MGI

neuromuscular process controlling balance

Inferred from mutant phenotype PubMed 9918704. Source: MGI

neuromuscular process controlling posture

Inferred from mutant phenotype PubMed 2061715. Source: MGI

phospholipid metabolic process

Inferred from mutant phenotype PubMed 9245501. Source: MGI

photoreceptor cell maintenance

Inferred from mutant phenotype PubMed 15565184PubMed 9151333. Source: MGI

regulation of cell size

Inferred from mutant phenotype PubMed 15565184. Source: MGI

retina development in camera-type eye

Inferred from mutant phenotype PubMed 15565184PubMed 21052544. Source: MGI

social behavior

Inferred from mutant phenotype PubMed 12020865. Source: MGI

somatic motor neuron differentiation

Inferred from mutant phenotype PubMed 21052544. Source: MGI

spinal cord motor neuron differentiation

Inferred from mutant phenotype PubMed 2061715. Source: MGI

visual perception

Inferred from mutant phenotype PubMed 7668363PubMed 7683855PubMed 8125718PubMed 8282051. Source: MGI

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum-Golgi intermediate compartment

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrion

Inferred from mutant phenotype PubMed 9059519. Source: GOC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q542J5 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: A11225DE3CD7DEA5

FASTA28833,109
        10         20         30         40         50         60 
MTPVSSHGLA ESIFDLDYAS WKIRSTLAVA GFVFYLGVFV VCHQLSSSLN ATYRSLAAKE 

        70         80         90        100        110        120 
KVFWNLAATR AVFGVQSTTA GLWALLGDPV LYADKALGQQ NWCWFHITTA TGFFFFENVA 

       130        140        150        160        170        180 
VHLSNLFFRT FDLFLVVHHL FAFLGFLGSA INLRAGHYLA MTTLLLEMST PFTCISWMLL 

       190        200        210        220        230        240 
KAGWSDSLFW KANQWLMIHM FHCRMILTYH MWWVCFCHWD ALTSSLHLPH WALFLFGLAL 

       250        260        270        280 
LTAVINPYWT HKKTQQLLHP VDWNFAQEEA KGSRQERTNG QVPRKKRL 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1.
Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1.
Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1.
Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1.
Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC33570.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1.
Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[7]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL22189.1.
[8]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAC40269.1.
Tissue: Activated spleen EMBL BAC40944.1 and Thymus EMBL BAC40269.1.
[9]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE37712.1 and NOD EMBL BAE41313.1.
Tissue: Thymus EMBL BAE41313.1 and Whole body EMBL BAE37712.1.
[10]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1.
Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[11]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1.
Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[12]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL22189.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK049145 mRNA. Translation: BAC33570.1.
AK088300 mRNA. Translation: BAC40269.1.
AK089692 mRNA. Translation: BAC40944.1.
AK164268 mRNA. Translation: BAE37712.1.
AK166905 mRNA. Translation: BAE39107.1.
AK169698 mRNA. Translation: BAE41313.1.
AK171446 mRNA. Translation: BAE42456.1.
CH466566 Genomic DNA. Translation: EDL22189.1.
CH466566 Genomic DNA. Translation: EDL22190.1.
CH466566 Genomic DNA. Translation: EDL22191.1.
CH466566 Genomic DNA. Translation: EDL22192.1.
RefSeqNP_036130.1. NM_012000.3.
XP_006508869.1. XM_006508806.1.
XP_006508870.1. XM_006508807.1.
UniGeneMm.254027.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID26889.
KEGGmmu:26889.

Organism-specific databases

CTD2055.
MGIMGI:1349447. Cln8.

Phylogenomic databases

HOVERGENHBG028338.
InParanoidQ542J5.
KOK12360.
OMALTYHMWW.

Gene expression databases

GenevestigatorQ542J5.

Family and domain databases

InterProIPR006634. TLC-dom.
[Graphical view]
PfamPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTSM00724. TLC. 1 hit.
[Graphical view]
PROSITEPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304715.
SOURCESearch...

Entry information

Entry nameQ542J5_MOUSE
AccessionPrimary (citable) accession number: Q542J5
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)