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Q542J5

- Q542J5_MOUSE

UniProt

Q542J5 - Q542J5_MOUSE

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Protein
Submitted name: Ceroid-lipofuscinosis, neuronal 8, isoform CRA_a
Gene
Cln8, mCG_14825
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. L-glutamate uptake involved in synaptic transmission Source: MGI
  2. adult locomotory behavior Source: MGI
  3. adult walking behavior Source: MGI
  4. age-dependent response to oxidative stress Source: MGI
  5. associative learning Source: MGI
  6. cellular macromolecule catabolic process Source: MGI
  7. cellular protein catabolic process Source: MGI
  8. cellular protein metabolic process Source: MGI
  9. ceramide metabolic process Source: Ensembl
  10. cholesterol metabolic process Source: Ensembl
  11. lysosome organization Source: MGI
  12. mitochondrial membrane organization Source: MGI
  13. musculoskeletal movement Source: MGI
  14. negative regulation of apoptotic process Source: MGI
  15. negative regulation of transferase activity Source: MGI
  16. neurofilament cytoskeleton organization Source: MGI
  17. neuromuscular process controlling balance Source: MGI
  18. neuromuscular process controlling posture Source: MGI
  19. phospholipid metabolic process Source: MGI
  20. photoreceptor cell maintenance Source: MGI
  21. regulation of cell size Source: MGI
  22. retina development in camera-type eye Source: MGI
  23. social behavior Source: MGI
  24. somatic motor neuron differentiation Source: MGI
  25. spinal cord motor neuron differentiation Source: MGI
  26. visual perception Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ceroid-lipofuscinosis, neuronal 8, isoform CRA_aImported
Gene namesi
Name:Cln8Imported
ORF Names:mCG_14825Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1349447. Cln8.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. mitochondrion Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ542J5.

Family & Domainsi

Sequence similaritiesi

Contains TLC (TRAM/LAG1/CLN8) domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG028338.
InParanoidiQ542J5.
KOiK12360.
OMAiLTYHMWW.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q542J5-1 [UniParc]FASTAAdd to Basket

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MTPVSSHGLA ESIFDLDYAS WKIRSTLAVA GFVFYLGVFV VCHQLSSSLN    50
ATYRSLAAKE KVFWNLAATR AVFGVQSTTA GLWALLGDPV LYADKALGQQ 100
NWCWFHITTA TGFFFFENVA VHLSNLFFRT FDLFLVVHHL FAFLGFLGSA 150
INLRAGHYLA MTTLLLEMST PFTCISWMLL KAGWSDSLFW KANQWLMIHM 200
FHCRMILTYH MWWVCFCHWD ALTSSLHLPH WALFLFGLAL LTAVINPYWT 250
HKKTQQLLHP VDWNFAQEEA KGSRQERTNG QVPRKKRL 288
Length:288
Mass (Da):33,109
Last modified:May 24, 2005 - v1
Checksum:iA11225DE3CD7DEA5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK049145 mRNA. Translation: BAC33570.1.
AK088300 mRNA. Translation: BAC40269.1.
AK089692 mRNA. Translation: BAC40944.1.
AK164268 mRNA. Translation: BAE37712.1.
AK166905 mRNA. Translation: BAE39107.1.
AK169698 mRNA. Translation: BAE41313.1.
AK171446 mRNA. Translation: BAE42456.1.
CH466566 Genomic DNA. Translation: EDL22189.1.
CH466566 Genomic DNA. Translation: EDL22190.1.
CH466566 Genomic DNA. Translation: EDL22191.1.
CH466566 Genomic DNA. Translation: EDL22192.1.
RefSeqiNP_036130.1. NM_012000.3.
XP_006508869.1. XM_006508806.1.
XP_006508870.1. XM_006508807.1.
UniGeneiMm.254027.

Genome annotation databases

GeneIDi26889.
KEGGimmu:26889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK049145 mRNA. Translation: BAC33570.1 .
AK088300 mRNA. Translation: BAC40269.1 .
AK089692 mRNA. Translation: BAC40944.1 .
AK164268 mRNA. Translation: BAE37712.1 .
AK166905 mRNA. Translation: BAE39107.1 .
AK169698 mRNA. Translation: BAE41313.1 .
AK171446 mRNA. Translation: BAE42456.1 .
CH466566 Genomic DNA. Translation: EDL22189.1 .
CH466566 Genomic DNA. Translation: EDL22190.1 .
CH466566 Genomic DNA. Translation: EDL22191.1 .
CH466566 Genomic DNA. Translation: EDL22192.1 .
RefSeqi NP_036130.1. NM_012000.3.
XP_006508869.1. XM_006508806.1.
XP_006508870.1. XM_006508807.1.
UniGenei Mm.254027.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 26889.
KEGGi mmu:26889.

Organism-specific databases

CTDi 2055.
MGIi MGI:1349447. Cln8.

Phylogenomic databases

HOVERGENi HBG028338.
InParanoidi Q542J5.
KOi K12360.
OMAi LTYHMWW.

Miscellaneous databases

NextBioi 304715.
SOURCEi Search...

Gene expression databases

Genevestigatori Q542J5.

Family and domain databases

InterProi IPR006634. TLC-dom.
[Graphical view ]
Pfami PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view ]
SMARTi SM00724. TLC. 1 hit.
[Graphical view ]
PROSITEi PS50922. TLC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported and ThymusImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: ThymusImported and Whole bodyImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, ThymusImported and Whole bodyImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ542J5_MOUSE
AccessioniPrimary (citable) accession number: Q542J5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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