Q542J5 (Q542J5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ceroid-lipofuscinosis, neuronal 8, isoform CRA_a EMBL EDL22189.1

Gene names

Name:	Cln8 MGI 1349447 EMBL EDL22189.1
ORF Names:	mCG_14825 EMBL EDL22189.1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 TLC (TRAM/LAG1/CLN8) domain. SAAS SAAS006634

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS006634
Gene Ontology (GO)
Biological_process	L-glutamate uptake involved in synaptic transmission Inferred from mutant phenotype PubMed 8095977PubMed 9600674. Source: MGI adult walking behavior Inferred from mutant phenotype PubMed 10215924PubMed 2061715PubMed 3783318PubMed 7668363PubMed 7683855PubMed 9918704. Source: MGI age-dependent response to oxidative stress Inferred from mutant phenotype PubMed 15213005. Source: MGI associative learning Inferred from mutant phenotype PubMed 15885820. Source: MGI cellular protein catabolic process Inferred from mutant phenotype PubMed 8389815. Source: MGI ceramide metabolic process Inferred from electronic annotation. Source: Compara cholesterol metabolic process Inferred from electronic annotation. Source: Compara lysosome organization Inferred from mutant phenotype PubMed 10087069PubMed 7613514PubMed 8144516PubMed 8160780. Source: MGI mitochondrial membrane organization Inferred from mutant phenotype PubMed 9059519. Source: MGI musculoskeletal movement Inferred from mutant phenotype PubMed 2061715. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 15565184. Source: MGI negative regulation of transferase activity Inferred from mutant phenotype PubMed 8873145. Source: MGI neurofilament cytoskeleton organization Inferred from mutant phenotype PubMed 2061715. Source: MGI neuromuscular process controlling balance Inferred from mutant phenotype PubMed 9918704. Source: MGI neuromuscular process controlling posture Inferred from mutant phenotype PubMed 2061715. Source: MGI phospholipid metabolic process Inferred from mutant phenotype PubMed 9245501. Source: MGI photoreceptor cell maintenance Inferred from mutant phenotype PubMed 15565184PubMed 9151333. Source: MGI regulation of cell size Inferred from mutant phenotype PubMed 15565184. Source: MGI retina development in camera-type eye Inferred from mutant phenotype PubMed 15565184PubMed 21052544. Source: MGI social behavior Inferred from mutant phenotype PubMed 12020865. Source: MGI somatic motor neuron differentiation Inferred from mutant phenotype PubMed 21052544. Source: MGI
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: Compara endoplasmic reticulum-Golgi intermediate compartment Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q542J5 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: A11225DE3CD7DEA5	FASTA	288	33,109
	10 20 30 40 50 60 MTPVSSHGLA ESIFDLDYAS WKIRSTLAVA GFVFYLGVFV VCHQLSSSLN ATYRSLAAKE 70 80 90 100 110 120 KVFWNLAATR AVFGVQSTTA GLWALLGDPV LYADKALGQQ NWCWFHITTA TGFFFFENVA 130 140 150 160 170 180 VHLSNLFFRT FDLFLVVHHL FAFLGFLGSA INLRAGHYLA MTTLLLEMST PFTCISWMLL 190 200 210 220 230 240 KAGWSDSLFW KANQWLMIHM FHCRMILTYH MWWVCFCHWD ALTSSLHLPH WALFLFGLAL 250 260 270 280 LTAVINPYWT HKKTQQLLHP VDWNFAQEEA KGSRQERTNG QVPRKKRL

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1. Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1. Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1. Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1. Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[5]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33570.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1. Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[7]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL22189.1.
[8]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAC40269.1. Tissue: Activated spleen EMBL BAC40944.1 and Thymus EMBL BAC40269.1.
[9]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37712.1 and NOD EMBL BAE41313.1. Tissue: Thymus EMBL BAE41313.1 and Whole body EMBL BAE37712.1.
[10]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1. Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[11]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC33570.1 and NOD EMBL BAC40269.1. Tissue: Activated spleen EMBL BAC40944.1, Thymus EMBL BAC40269.1 and Whole body EMBL BAE37712.1.
[12]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL22189.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK049145 mRNA. Translation: BAC33570.1. AK088300 mRNA. Translation: BAC40269.1. AK089692 mRNA. Translation: BAC40944.1. AK164268 mRNA. Translation: BAE37712.1. AK166905 mRNA. Translation: BAE39107.1. AK169698 mRNA. Translation: BAE41313.1. AK171446 mRNA. Translation: BAE42456.1. CH466566 Genomic DNA. Translation: EDL22189.1. CH466566 Genomic DNA. Translation: EDL22190.1. CH466566 Genomic DNA. Translation: EDL22191.1. CH466566 Genomic DNA. Translation: EDL22192.1.
IPI	IPI00131726.
RefSeq	NP_036130.1. NM_012000.3.
UniGene	Mm.254027.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	26889.
KEGG	mmu:26889.
UCSC	uc009kze.1. mouse.
Organism-specific databases
CTD	2055.
MGI	MGI:1349447. Cln8.
Phylogenomic databases
HOVERGEN	HBG028338.
InParanoid	Q542J5.
KO	K12360.
OMA	LTYHMWW.
Gene expression databases
Genevestigator	Q542J5.
Family and domain databases
InterPro	IPR006634. TLC-dom. [Graphical view]
Pfam	PF03798. TRAM_LAG1_CLN8. 1 hit. [Graphical view]
SMART	SM00724. TLC. 1 hit. [Graphical view]
PROSITE	PS50922. TLC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	304715.
SOURCE	Search...

Entry information

Entry name

Q542J5_MOUSE

Accession

Primary (citable) accession number: Q542J5

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)