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Q542J1

- Q542J1_MOUSE

UniProt

Q542J1 - Q542J1_MOUSE

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Protein
Submitted name: Putative uncharacterized protein
Gene
Fzd6
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: RefGenome
  4. Wnt-protein binding Source: MGI
  5. protein binding Source: MGI

GO - Biological processi

  1. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
  2. Wnt signaling pathway, planar cell polarity pathway Source: MGI
  3. angiogenesis Source: RefGenome
  4. axonogenesis Source: RefGenome
  5. canonical Wnt signaling pathway Source: RefGenome
  6. cell proliferation in midbrain Source: MGI
  7. embryonic nail plate morphogenesis Source: MGI
  8. establishment of planar polarity Source: MGI
  9. gonad development Source: RefGenome
  10. hair follicle development Source: MGI
  11. inner ear morphogenesis Source: MGI
  12. midbrain development Source: MGI
  13. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  14. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  15. neural tube closure Source: MGI
  16. platelet activation Source: MGI
  17. regulation of transcription from RNA polymerase II promoter Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotations, ReceptorSAAS annotations

Keywords - Biological processi

Wnt signaling pathwaySAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Fzd6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:108474. Fzd6.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: MGI
  2. apicolateral plasma membrane Source: MGI
  3. cytoplasm Source: RefGenome
  4. integral component of membrane Source: UniProtKB-KW
  5. neuron projection membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Proteomic databases

PRIDEiQ542J1.

Expressioni

Gene expression databases

ArrayExpressiQ542J1.
BgeeiQ542J1.
GenevestigatoriQ542J1.

Structurei

3D structure databases

ProteinModelPortaliQ542J1.
SMRiQ542J1. Positions 24-127, 178-503.

Family & Domainsi

Sequence similaritiesi

Contains FZ (frizzled) domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG006977.
InParanoidiQ542J1.
KOiK02376.
OMAiCPYQAKA.
PhylomeDBiQ542J1.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q542J1-1 [UniParc]FASTAAdd to Basket

« Hide

MERSPFLLAC ILLPLVRGHS LFTCEPITVP RCMKMTYNMT FFPNLMGHYD    50
QGIAAVEMGH FLHLANLECS PNIEMFLCQA FIPTCTEQIH VVLPCRKLCE 100
KIVSDCKKLM DTFGIRWPEE LECNRLPHCD DTVPVTSHPH TELSGPQKKS 150
DQVPRDIGFW CPKHLRTSGD QGYRFLGIEQ CAPPCPNMYF KSDELDFAKS 200
FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC YSIVSLMYFV 250
GFLLGNSTAC NKADEKLELG DTVVLGSKNK ACSVVFMFLY FFTMAGTVWW 300
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGAPGFLTV MLLAMNKVEG 350
DNISGVCFVG LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI 400
QHDGRNQEKL KKFMIRIGVF SGLYLVPLVT LLGCYVYELV NRITWEMTWF 450
SDHCHQYRIP CPYQANPKAR PELALFMIKY LMTLIVGISA VFWVGSKKTC 500
TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK KKHGAPGPHR 550
LKVISKSMGT STGATTNHGT SAMAIADHDY LGQETSTEVH TSPEASVKEG 600
RADRANTPSA KDRDCGESAG PSSKLSGNRN GRESRAGGLK ERSNGSEGAP 650
SEGRVSPKSS VPETGLIDCS TSQAASSPEP TSLKGSTSLP VHSASRARKE 700
QGAGSHSDA 709
Length:709
Mass (Da):79,082
Last modified:May 24, 2005 - v1
Checksum:i01374A9EC9122484
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088399 mRNA. Translation: BAC40329.1.
RefSeqiNP_001155966.1. NM_001162494.1.
NP_032082.3. NM_008056.3.
UniGeneiMm.4769.

Genome annotation databases

GeneIDi14368.
KEGGimmu:14368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088399 mRNA. Translation: BAC40329.1 .
RefSeqi NP_001155966.1. NM_001162494.1.
NP_032082.3. NM_008056.3.
UniGenei Mm.4769.

3D structure databases

ProteinModelPortali Q542J1.
SMRi Q542J1. Positions 24-127, 178-503.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q542J1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 14368.
KEGGi mmu:14368.

Organism-specific databases

CTDi 8323.
MGIi MGI:108474. Fzd6.

Phylogenomic databases

HOVERGENi HBG006977.
InParanoidi Q542J1.
KOi K02376.
OMAi CPYQAKA.
PhylomeDBi Q542J1.

Miscellaneous databases

ChiTaRSi FZD6. mouse.
NextBioi 285845.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q542J1.
Bgeei Q542J1.
Genevestigatori Q542J1.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiQ542J1_MOUSE
AccessioniPrimary (citable) accession number: Q542J1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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