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Q542J1

- Q542J1_MOUSE

UniProt

Q542J1 - Q542J1_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Fzd6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. PDZ domain binding Source: RefGenome
    2. protein binding Source: MGI
    3. Wnt-activated receptor activity Source: RefGenome
    4. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: RefGenome
    2. axonogenesis Source: RefGenome
    3. canonical Wnt signaling pathway Source: RefGenome
    4. cell proliferation in midbrain Source: MGI
    5. embryonic nail plate morphogenesis Source: MGI
    6. establishment of planar polarity Source: MGI
    7. gonad development Source: RefGenome
    8. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
    9. hair follicle development Source: MGI
    10. inner ear morphogenesis Source: MGI
    11. midbrain development Source: MGI
    12. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    13. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    14. neural tube closure Source: MGI
    15. platelet activation Source: MGI
    16. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    17. Wnt signaling pathway, planar cell polarity pathway Source: MGI

    Keywords - Molecular functioni

    Developmental proteinSAAS annotation, ReceptorSAAS annotation

    Keywords - Biological processi

    Wnt signaling pathwaySAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Fzd6Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:108474. Fzd6.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: MGI
    2. apicolateral plasma membrane Source: MGI
    3. cytoplasm Source: RefGenome
    4. integral component of membrane Source: UniProtKB-KW
    5. neuron projection membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiQ542J1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ542J1.
    BgeeiQ542J1.
    GenevestigatoriQ542J1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ542J1.
    SMRiQ542J1. Positions 24-127, 178-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains FZ (frizzled) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG006977.
    InParanoidiQ542J1.
    KOiK02376.
    OMAiCPYQAKA.
    PhylomeDBiQ542J1.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026543. FZD6.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF75. PTHR11309:SF75. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q542J1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERSPFLLAC ILLPLVRGHS LFTCEPITVP RCMKMTYNMT FFPNLMGHYD    50
    QGIAAVEMGH FLHLANLECS PNIEMFLCQA FIPTCTEQIH VVLPCRKLCE 100
    KIVSDCKKLM DTFGIRWPEE LECNRLPHCD DTVPVTSHPH TELSGPQKKS 150
    DQVPRDIGFW CPKHLRTSGD QGYRFLGIEQ CAPPCPNMYF KSDELDFAKS 200
    FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC YSIVSLMYFV 250
    GFLLGNSTAC NKADEKLELG DTVVLGSKNK ACSVVFMFLY FFTMAGTVWW 300
    VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGAPGFLTV MLLAMNKVEG 350
    DNISGVCFVG LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI 400
    QHDGRNQEKL KKFMIRIGVF SGLYLVPLVT LLGCYVYELV NRITWEMTWF 450
    SDHCHQYRIP CPYQANPKAR PELALFMIKY LMTLIVGISA VFWVGSKKTC 500
    TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK KKHGAPGPHR 550
    LKVISKSMGT STGATTNHGT SAMAIADHDY LGQETSTEVH TSPEASVKEG 600
    RADRANTPSA KDRDCGESAG PSSKLSGNRN GRESRAGGLK ERSNGSEGAP 650
    SEGRVSPKSS VPETGLIDCS TSQAASSPEP TSLKGSTSLP VHSASRARKE 700
    QGAGSHSDA 709
    Length:709
    Mass (Da):79,082
    Last modified:May 24, 2005 - v1
    Checksum:i01374A9EC9122484
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088399 mRNA. Translation: BAC40329.1.
    RefSeqiNP_001155966.1. NM_001162494.1.
    NP_032082.3. NM_008056.3.
    UniGeneiMm.4769.

    Genome annotation databases

    GeneIDi14368.
    KEGGimmu:14368.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088399 mRNA. Translation: BAC40329.1 .
    RefSeqi NP_001155966.1. NM_001162494.1.
    NP_032082.3. NM_008056.3.
    UniGenei Mm.4769.

    3D structure databases

    ProteinModelPortali Q542J1.
    SMRi Q542J1. Positions 24-127, 178-503.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q542J1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 14368.
    KEGGi mmu:14368.

    Organism-specific databases

    CTDi 8323.
    MGIi MGI:108474. Fzd6.

    Phylogenomic databases

    HOVERGENi HBG006977.
    InParanoidi Q542J1.
    KOi K02376.
    OMAi CPYQAKA.
    PhylomeDBi Q542J1.

    Miscellaneous databases

    ChiTaRSi FZD6. mouse.
    NextBioi 285845.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q542J1.
    Bgeei Q542J1.
    Genevestigatori Q542J1.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026543. FZD6.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF75. PTHR11309:SF75. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.

    Entry informationi

    Entry nameiQ542J1_MOUSE
    AccessioniPrimary (citable) accession number: Q542J1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)