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Protein

Proteasome subunit alpha type

Gene

Psma7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:Psma7Imported
ORF Names:mCG_6735Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1347070 Psma7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmPROSITE-ProRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomePROSITE-ProRule annotationImported

PTM / Processingi

Proteomic databases

PRIDEiQ542H2
TopDownProteomicsiQ542H2

Expressioni

Gene expression databases

BgeeiENSMUSG00000027566
ExpressionAtlasiQ542H2 baseline and differential

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ542H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 25PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili225 – 245Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0183 Eukaryota
ENOG410XP21 LUCA
HOVERGENiHBG003005
KOiK02731
OMAiPYTQKPA
OrthoDBiEOG091G0GX6

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR035190 Proteasome_alpha7
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF40 PTHR11599:SF40, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q542H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGKDI VVLGVEKKSV
60 70 80 90 100
AKLQDERTVR KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED
110 120 130 140 150
PVTVEYITRY IASLKQRYTQ SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS
160 170 180 190 200
GTYHAWKANA IGRGAKSVRE FLEKNYTDDA IETDDLTIKL VIKALLEVVQ
210 220 230 240
SGGKNIELAV MRRDQPLKIL NPEEIEKYVA EIEKEKEENE KKKQKKAS
Length:248
Mass (Da):27,855
Last modified:May 24, 2005 - v1
Checksum:iE2C8D607D8E2BC9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088615 mRNA Translation: BAC40454.1
CH466626 Genomic DNA Translation: EDL07305.1
RefSeqiNP_036099.1, NM_011969.2
UniGeneiMm.21728

Genome annotation databases

GeneIDi26444
KEGGimmu:26444

Similar proteinsi

Entry informationi

Entry nameiQ542H2_MOUSE
AccessioniPrimary (citable) accession number: Q542H2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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