ID   Q542G9_MOUSE            Unreviewed;       339 AA.
AC   Q542G9;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 164.
DE   RecName: Full=Annexin {ECO:0000256|RuleBase:RU003540};
GN   Name=Anxa2 {ECO:0000313|MGI:MGI:88246};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC40474.1};
RN   [1] {ECO:0000313|EMBL:BAC40474.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/C {ECO:0000313|EMBL:BAE40056.1}, C57BL/6J
RC   {ECO:0000313|EMBL:BAE26899.1}, DBA/2 {ECO:0000313|EMBL:BAE39905.1},
RC   and NOD {ECO:0000313|EMBL:BAC40474.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31314.1}, Heart
RC   {ECO:0000313|EMBL:BAE37816.1}, Lung {ECO:0000313|EMBL:BAE38439.1},
RC   Placenta {ECO:0000313|EMBL:BAE26899.1}, and Thymus
RC   {ECO:0000313|EMBL:BAC40474.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAC40474.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/C {ECO:0000313|EMBL:BAE40056.1}, C57BL/6J
RC   {ECO:0000313|EMBL:BAE26899.1}, DBA/2 {ECO:0000313|EMBL:BAE39905.1},
RC   and NOD {ECO:0000313|EMBL:BAC40474.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31314.1}, Heart
RC   {ECO:0000313|EMBL:BAE37816.1}, Lung {ECO:0000313|EMBL:BAE38439.1},
RC   Placenta {ECO:0000313|EMBL:BAE26899.1}, and Thymus
RC   {ECO:0000313|EMBL:BAC40474.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAC40474.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/C {ECO:0000313|EMBL:BAE40056.1}, C57BL/6J
RC   {ECO:0000313|EMBL:BAE26899.1}, DBA/2 {ECO:0000313|EMBL:BAE39905.1},
RC   and NOD {ECO:0000313|EMBL:BAC40474.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31314.1}, Heart
RC   {ECO:0000313|EMBL:BAE37816.1}, Lung {ECO:0000313|EMBL:BAE38439.1},
RC   Placenta {ECO:0000313|EMBL:BAE26899.1}, and Thymus
RC   {ECO:0000313|EMBL:BAC40474.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAC40474.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/C {ECO:0000313|EMBL:BAE40056.1}, C57BL/6J
RC   {ECO:0000313|EMBL:BAE26899.1}, DBA/2 {ECO:0000313|EMBL:BAE39905.1},
RC   and NOD {ECO:0000313|EMBL:BAC40474.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31314.1}, Heart
RC   {ECO:0000313|EMBL:BAE37816.1}, Lung {ECO:0000313|EMBL:BAE38439.1},
RC   Placenta {ECO:0000313|EMBL:BAE26899.1}, and Thymus
RC   {ECO:0000313|EMBL:BAC40474.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAC40474.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/C {ECO:0000313|EMBL:BAE40056.1}, C57BL/6J
RC   {ECO:0000313|EMBL:BAE26899.1}, DBA/2 {ECO:0000313|EMBL:BAE39905.1},
RC   and NOD {ECO:0000313|EMBL:BAC40474.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31314.1}, Heart
RC   {ECO:0000313|EMBL:BAE37816.1}, Lung {ECO:0000313|EMBL:BAE38439.1},
RC   Placenta {ECO:0000313|EMBL:BAE26899.1}, and Thymus
RC   {ECO:0000313|EMBL:BAC40474.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [6] {ECO:0000313|EMBL:BAC40474.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD {ECO:0000313|EMBL:BAC40474.1};
RC   TISSUE=Thymus {ECO:0000313|EMBL:BAC40474.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA   Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA   Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA   Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA   Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA   Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA   Hayashizaki Y.;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:BAE37816.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/C {ECO:0000313|EMBL:BAE40056.1}, C57BL/6J
RC   {ECO:0000313|EMBL:BAE26899.1}, and DBA/2
RC   {ECO:0000313|EMBL:BAE39905.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31314.1}, Heart
RC   {ECO:0000313|EMBL:BAE37816.1}, Lung {ECO:0000313|EMBL:BAE38439.1}, and
RC   Placenta {ECO:0000313|EMBL:BAE26899.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA   Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA   Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA   Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA   Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0007829|PubMed:15592455}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=15592455; DOI=10.1038/nbt1046;
RA   Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA   Zha X.M., Polakiewicz R.D., Comb M.J.;
RT   "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
RL   Nat. Biotechnol. 23:94-101(2005).
RN   [9] {ECO:0000313|EMBL:BAC40474.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/C {ECO:0000313|EMBL:BAE40056.1}, C57BL/6J
RC   {ECO:0000313|EMBL:BAE26899.1}, DBA/2 {ECO:0000313|EMBL:BAE39905.1},
RC   and NOD {ECO:0000313|EMBL:BAC40474.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31314.1}, Heart
RC   {ECO:0000313|EMBL:BAE37816.1}, Lung {ECO:0000313|EMBL:BAE38439.1},
RC   Placenta {ECO:0000313|EMBL:BAE26899.1}, and Thymus
RC   {ECO:0000313|EMBL:BAC40474.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [10] {ECO:0000313|EMBL:BAC40474.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/C {ECO:0000313|EMBL:BAE40056.1}, C57BL/6J
RC   {ECO:0000313|EMBL:BAE26899.1}, DBA/2 {ECO:0000313|EMBL:BAE39905.1},
RC   and NOD {ECO:0000313|EMBL:BAC40474.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31314.1}, Heart
RC   {ECO:0000313|EMBL:BAE37816.1}, Lung {ECO:0000313|EMBL:BAE38439.1},
RC   Placenta {ECO:0000313|EMBL:BAE26899.1}, and Thymus
RC   {ECO:0000313|EMBL:BAC40474.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [11] {ECO:0007829|PubMed:19144319}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [12] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [13] {ECO:0007829|PubMed:23806337}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA   Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC       Secreted, extracellular space, extracellular matrix, basement membrane
CC       {ECO:0000256|ARBA:ARBA00004302}.
CC   -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium
CC       and phospholipid. {ECO:0000256|RuleBase:RU003540}.
CC   -!- SIMILARITY: Belongs to the annexin family.
CC       {ECO:0000256|ARBA:ARBA00007831, ECO:0000256|RuleBase:RU003540}.
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DR   EMBL; AK088645; BAC40474.1; -; mRNA.
DR   EMBL; AK146096; BAE26899.1; -; mRNA.
DR   EMBL; AK152561; BAE31314.1; -; mRNA.
DR   EMBL; AK164507; BAE37816.1; -; mRNA.
DR   EMBL; AK165888; BAE38439.1; -; mRNA.
DR   EMBL; AK167894; BAE39905.1; -; mRNA.
DR   EMBL; AK168083; BAE40056.1; -; mRNA.
DR   RefSeq; NP_031611.1; NM_007585.3.
DR   RefSeq; XP_006510859.1; XM_006510796.2.
DR   AlphaFoldDB; Q542G9; -.
DR   SMR; Q542G9; -.
DR   SwissPalm; Q542G9; -.
DR   MaxQB; Q542G9; -.
DR   TopDownProteomics; Q542G9; -.
DR   Antibodypedia; 3808; 964 antibodies from 46 providers.
DR   DNASU; 12306; -.
DR   GeneID; 12306; -.
DR   KEGG; mmu:12306; -.
DR   AGR; MGI:88246; -.
DR   CTD; 302; -.
DR   MGI; MGI:88246; Anxa2.
DR   VEuPathDB; HostDB:ENSMUSG00000032231; -.
DR   HOGENOM; CLU_025300_0_0_1; -.
DR   OMA; DLMRIRT; -.
DR   OrthoDB; 1500773at2759; -.
DR   BioGRID-ORCS; 12306; 2 hits in 84 CRISPR screens.
DR   ChiTaRS; Anxa2; mouse.
DR   ExpressionAtlas; Q542G9; baseline and differential.
DR   GO; GO:1990665; C:AnxA2-p11 complex; IEA:Ensembl.
DR   GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
DR   GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:1990667; C:PCSK9-AnxA2 complex; IEA:Ensembl.
DR   GO; GO:0098797; C:plasma membrane protein complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0044548; F:S100 protein binding; IEA:Ensembl.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0001765; P:membrane raft assembly; IEA:Ensembl.
DR   GO; GO:0032804; P:negative regulation of low-density lipoprotein particle receptor catabolic process; IEA:Ensembl.
DR   GO; GO:0002091; P:negative regulation of receptor internalization; IEA:Ensembl.
DR   GO; GO:0036035; P:osteoclast development; IEA:Ensembl.
DR   GO; GO:1905581; P:positive regulation of low-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:0010756; P:positive regulation of plasminogen activation; IEA:Ensembl.
DR   GO; GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
DR   GO; GO:1905602; P:positive regulation of receptor-mediated endocytosis involved in cholesterol transport; IEA:Ensembl.
DR   GO; GO:0044090; P:positive regulation of vacuole organization; IEA:Ensembl.
DR   GO; GO:0031340; P:positive regulation of vesicle fusion; IEA:Ensembl.
DR   GO; GO:0006900; P:vesicle budding from membrane; IEA:Ensembl.
DR   Gene3D; 1.10.220.10; Annexin; 4.
DR   InterPro; IPR001464; Annexin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR018252; Annexin_repeat_CS.
DR   InterPro; IPR037104; Annexin_sf.
DR   InterPro; IPR002389; ANX2.
DR   PANTHER; PTHR10502; ANNEXIN; 1.
DR   PANTHER; PTHR10502:SF18; ANNEXIN A2-RELATED; 1.
DR   Pfam; PF00191; Annexin; 4.
DR   PRINTS; PR00196; ANNEXIN.
DR   PRINTS; PR00198; ANNEXINII.
DR   SMART; SM00335; ANX; 4.
DR   SUPFAM; SSF47874; Annexin; 1.
DR   PROSITE; PS00223; ANNEXIN_1; 3.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   1: Evidence at protein level;
KW   Annexin {ECO:0000256|ARBA:ARBA00023216, ECO:0000256|RuleBase:RU003540};
KW   Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU003540};
KW   Calcium/phospholipid-binding {ECO:0000256|ARBA:ARBA00023302,
KW   ECO:0000256|RuleBase:RU003540};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU003540};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
SQ   SEQUENCE   339 AA;  38676 MW;  4407E572097FB2C0 CRC64;
     MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG VDEVTIVNIL
     TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG
     LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA
     EDGSVIDYEL IDQDARELYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM
     LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM
     LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
//