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Q542G9

- Q542G9_MOUSE

UniProt

Q542G9 - Q542G9_MOUSE

Protein

Annexin

Gene

Anxa2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
    4. phospholipase inhibitor activity Source: InterPro
    5. protein binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. body fluid secretion Source: Ensembl
    3. cellular response to acid chemical Source: MGI
    4. collagen fibril organization Source: MGI
    5. fibrinolysis Source: MGI
    6. positive regulation of binding Source: MGI
    7. positive regulation of fibroblast proliferation Source: Ensembl
    8. positive regulation of protein phosphorylation Source: Ensembl
    9. positive regulation of vesicle fusion Source: Ensembl
    10. protein targeting to plasma membrane Source: Ensembl

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AnnexinUniRule annotation
    Gene namesi
    Name:Anxa2Imported
    ORF Names:mCG_5731Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88246. Anxa2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. cytoplasm Source: MGI
    3. early endosome Source: MGI
    4. extracellular vesicular exosome Source: Ensembl
    5. extrinsic component of plasma membrane Source: MGI
    6. lipid particle Source: Ensembl
    7. macropinosome Source: Ensembl
    8. midbody Source: Ensembl
    9. perinuclear region of cytoplasm Source: Ensembl
    10. protein complex Source: Ensembl
    11. ruffle Source: Ensembl
    12. sarcolemma Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ542G9.

    Family & Domainsi

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

    Sequence similaritiesi

    Belongs to the annexin family.UniRule annotation
    Contains 4 annexin repeats.UniRule annotation
    Contains annexin repeats.SAAS annotation

    Keywords - Domaini

    AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00680000099735.
    HOVERGENiHBG061815.
    InParanoidiQ542G9.
    KOiK17092.
    OMAiFIQQDTK.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view]
    PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q542G9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG    50
    VDEVTIVNIL TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL 100
    GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
    YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARELYD 200
    AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG 250
    DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 300
    LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 339
    Length:339
    Mass (Da):38,676
    Last modified:May 24, 2005 - v1
    Checksum:i4407E572097FB2C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088645 mRNA. Translation: BAC40474.1.
    AK146096 mRNA. Translation: BAE26899.1.
    AK152561 mRNA. Translation: BAE31314.1.
    AK164507 mRNA. Translation: BAE37816.1.
    AK165888 mRNA. Translation: BAE38439.1.
    AK167894 mRNA. Translation: BAE39905.1.
    AK168083 mRNA. Translation: BAE40056.1.
    CH466522 Genomic DNA. Translation: EDL26171.1.
    CH466522 Genomic DNA. Translation: EDL26172.1.
    CH466522 Genomic DNA. Translation: EDL26173.1.
    RefSeqiNP_031611.1. NM_007585.3.
    XP_006510859.1. XM_006510796.1.
    UniGeneiMm.238343.

    Genome annotation databases

    GeneIDi12306.
    KEGGimmu:12306.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088645 mRNA. Translation: BAC40474.1 .
    AK146096 mRNA. Translation: BAE26899.1 .
    AK152561 mRNA. Translation: BAE31314.1 .
    AK164507 mRNA. Translation: BAE37816.1 .
    AK165888 mRNA. Translation: BAE38439.1 .
    AK167894 mRNA. Translation: BAE39905.1 .
    AK168083 mRNA. Translation: BAE40056.1 .
    CH466522 Genomic DNA. Translation: EDL26171.1 .
    CH466522 Genomic DNA. Translation: EDL26172.1 .
    CH466522 Genomic DNA. Translation: EDL26173.1 .
    RefSeqi NP_031611.1. NM_007585.3.
    XP_006510859.1. XM_006510796.1.
    UniGenei Mm.238343.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 12306.
    KEGGi mmu:12306.

    Organism-specific databases

    CTDi 302.
    MGIi MGI:88246. Anxa2.

    Phylogenomic databases

    GeneTreei ENSGT00680000099735.
    HOVERGENi HBG061815.
    InParanoidi Q542G9.
    KOi K17092.
    OMAi FIQQDTK.

    Miscellaneous databases

    NextBioi 280840.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q542G9.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view ]
    PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
      Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
      Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
      Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
      Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
      Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
    6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported and PlacentaImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/CImported, C57BL/6JImported and DBA/2Imported.
      Tissue: HeartImported and LungImported.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
      Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
      Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ542G9_MOUSE
    AccessioniPrimary (citable) accession number: Q542G9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)