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Q542G9

- Q542G9_MOUSE

UniProt

Q542G9 - Q542G9_MOUSE

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Protein
Annexin
Gene
Anxa2, mCG_5731
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. calcium-dependent phospholipid binding Source: UniProtKB-KW
  3. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
  4. phospholipase inhibitor activity Source: InterPro
  5. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. angiogenesis Source: MGI
  2. body fluid secretion Source: Ensembl
  3. cellular response to acid Source: MGI
  4. collagen fibril organization Source: MGI
  5. fibrinolysis Source: MGI
  6. positive regulation of binding Source: MGI
  7. positive regulation of fibroblast proliferation Source: Ensembl
  8. positive regulation of protein phosphorylation Source: Ensembl
  9. positive regulation of vesicle fusion Source: Ensembl
  10. protein targeting to plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:Anxa2Imported
ORF Names:mCG_5731Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88246. Anxa2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. cytoplasm Source: MGI
  3. early endosome Source: MGI
  4. extracellular vesicular exosome Source: Ensembl
  5. extrinsic component of plasma membrane Source: MGI
  6. lipid particle Source: Ensembl
  7. macropinosome Source: Ensembl
  8. midbody Source: Ensembl
  9. perinuclear region of cytoplasm Source: Ensembl
  10. protein complex Source: Ensembl
  11. ruffle Source: Ensembl
  12. sarcolemma Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ542G9.

Family & Domainsi

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation
Contains 4 annexin repeats.UniRule annotation
Contains annexin repeats.SAAS annotations

Keywords - Domaini

AnnexinUniRule annotationSAAS annotations, RepeatUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00680000099735.
HOVERGENiHBG061815.
InParanoidiQ542G9.
KOiK17092.
OMAiFIQQDTK.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q542G9-1 [UniParc]FASTAAdd to Basket

« Hide

MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG    50
VDEVTIVNIL TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL 100
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARELYD 200
AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG 250
DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 300
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 339
Length:339
Mass (Da):38,676
Last modified:May 24, 2005 - v1
Checksum:i4407E572097FB2C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088645 mRNA. Translation: BAC40474.1.
AK146096 mRNA. Translation: BAE26899.1.
AK152561 mRNA. Translation: BAE31314.1.
AK164507 mRNA. Translation: BAE37816.1.
AK165888 mRNA. Translation: BAE38439.1.
AK167894 mRNA. Translation: BAE39905.1.
AK168083 mRNA. Translation: BAE40056.1.
CH466522 Genomic DNA. Translation: EDL26171.1.
CH466522 Genomic DNA. Translation: EDL26172.1.
CH466522 Genomic DNA. Translation: EDL26173.1.
RefSeqiNP_031611.1. NM_007585.3.
XP_006510859.1. XM_006510796.1.
UniGeneiMm.238343.

Genome annotation databases

GeneIDi12306.
KEGGimmu:12306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088645 mRNA. Translation: BAC40474.1 .
AK146096 mRNA. Translation: BAE26899.1 .
AK152561 mRNA. Translation: BAE31314.1 .
AK164507 mRNA. Translation: BAE37816.1 .
AK165888 mRNA. Translation: BAE38439.1 .
AK167894 mRNA. Translation: BAE39905.1 .
AK168083 mRNA. Translation: BAE40056.1 .
CH466522 Genomic DNA. Translation: EDL26171.1 .
CH466522 Genomic DNA. Translation: EDL26172.1 .
CH466522 Genomic DNA. Translation: EDL26173.1 .
RefSeqi NP_031611.1. NM_007585.3.
XP_006510859.1. XM_006510796.1.
UniGenei Mm.238343.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12306.
KEGGi mmu:12306.

Organism-specific databases

CTDi 302.
MGIi MGI:88246. Anxa2.

Phylogenomic databases

GeneTreei ENSGT00680000099735.
HOVERGENi HBG061815.
InParanoidi Q542G9.
KOi K17092.
OMAi FIQQDTK.

Miscellaneous databases

NextBioi 280840.
SOURCEi Search...

Gene expression databases

Genevestigatori Q542G9.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view ]
PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and PlacentaImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and LungImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ542G9_MOUSE
AccessioniPrimary (citable) accession number: Q542G9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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