Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q542G9 (Q542G9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Annexin RuleBase RU003540
Gene names
Name:Anxa2 MGI 88246 EMBL EDL26171.1
ORF Names:mCG_5731 EMBL EDL26171.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid By similarity. RuleBase RU003540

Sequence similarities

Belongs to the annexin family. RuleBase RU003540

Contains 4 annexin repeats. RuleBase RU003540

Contains annexin repeats. SAAS SAAS018252

Ontologies

Keywords
   DomainAnnexin SAAS SAAS001464 RuleBase RU003540
Repeat SAAS SAAS001464 RuleBase RU003540
   LigandCalcium
Calcium/phospholipid-binding RuleBase RU003540
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from mutant phenotype PubMed 14702107. Source: MGI

body fluid secretion

Inferred from electronic annotation. Source: Ensembl

cellular response to acid

Inferred from direct assay PubMed 17690254. Source: MGI

collagen fibril organization

Inferred from mutant phenotype PubMed 14702107. Source: MGI

fibrinolysis

Inferred from mutant phenotype PubMed 14702107. Source: MGI

positive regulation of binding

Inferred from mutant phenotype PubMed 17690254. Source: MGI

positive regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of vesicle fusion

Inferred from electronic annotation. Source: Ensembl

protein targeting to plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell cortex

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 15078881. Source: MGI

early endosome

Inferred from direct assay PubMed 15078881. Source: MGI

extracellular vesicular exosome

Inferred from electronic annotation. Source: Ensembl

extrinsic component of plasma membrane

Inferred from direct assay PubMed 17690254. Source: MGI

lipid particle

Inferred from electronic annotation. Source: Ensembl

macropinosome

Inferred from electronic annotation. Source: Ensembl

midbody

Inferred from electronic annotation. Source: Ensembl

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

protein complex

Inferred from electronic annotation. Source: Ensembl

ruffle

Inferred from electronic annotation. Source: Ensembl

sarcolemma

Inferred from direct assay PubMed 14506282. Source: MGI

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

calcium-dependent phospholipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphatidylinositol-4,5-bisphosphate binding

Inferred from electronic annotation. Source: Ensembl

phospholipase inhibitor activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 14506282. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q542G9 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 4407E572097FB2C0

FASTA33938,676
        10         20         30         40         50         60 
MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG VDEVTIVNIL 

        70         80         90        100        110        120 
TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 

       130        140        150        160        170        180 
LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA 

       190        200        210        220        230        240 
EDGSVIDYEL IDQDARELYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM 

       250        260        270        280        290        300 
LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 

       310        320        330 
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1.
Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1.
Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1.
Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1.
Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1.
Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[6]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL26171.1.
[7]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAC40474.1.
Tissue: Thymus EMBL BAC40474.1.
[8]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26899.1.
Tissue: Bone marrow EMBL BAE31314.1 and Placenta EMBL BAE26899.1.
[9]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE37816.1 and DBA/2 EMBL BAE39905.1.
Tissue: Heart EMBL BAE37816.1 and Lung EMBL BAE38439.1.
[10]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1.
Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[11]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1.
Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[12]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL26171.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK088645 mRNA. Translation: BAC40474.1.
AK146096 mRNA. Translation: BAE26899.1.
AK152561 mRNA. Translation: BAE31314.1.
AK164507 mRNA. Translation: BAE37816.1.
AK165888 mRNA. Translation: BAE38439.1.
AK167894 mRNA. Translation: BAE39905.1.
AK168083 mRNA. Translation: BAE40056.1.
CH466522 Genomic DNA. Translation: EDL26171.1.
CH466522 Genomic DNA. Translation: EDL26172.1.
CH466522 Genomic DNA. Translation: EDL26173.1.
RefSeqNP_031611.1. NM_007585.3.
XP_006510859.1. XM_006510796.1.
UniGeneMm.238343.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID12306.
KEGGmmu:12306.

Organism-specific databases

CTD302.
MGIMGI:88246. Anxa2.

Phylogenomic databases

GeneTreeENSGT00680000099735.
HOVERGENHBG061815.
InParanoidQ542G9.
KOK17092.
OMAFIQQDTK.

Gene expression databases

GenevestigatorQ542G9.

Family and domain databases

Gene3D1.10.220.10. 4 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio280840.
SOURCESearch...

Entry information

Entry nameQ542G9_MOUSE
AccessionPrimary (citable) accession number: Q542G9
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)