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Q542G9

- Q542G9_MOUSE

UniProt

Q542G9 - Q542G9_MOUSE

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Protein

Annexin

Gene

Anxa2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
  4. phospholipase A2 inhibitor activity Source: Ensembl
  5. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: MGI
  2. body fluid secretion Source: Ensembl
  3. collagen fibril organization Source: MGI
  4. fibrinolysis Source: MGI
  5. membrane budding Source: Ensembl
  6. membrane raft assembly Source: Ensembl
  7. osteoclast development Source: Ensembl
  8. positive regulation of binding Source: MGI
  9. positive regulation of fibroblast proliferation Source: Ensembl
  10. positive regulation of protein phosphorylation Source: Ensembl
  11. positive regulation of vesicle fusion Source: Ensembl
  12. protein heterotetramerization Source: Ensembl
  13. protein targeting to plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:Anxa2Imported
ORF Names:mCG_5731Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88246. Anxa2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. cell surface Source: Ensembl
  3. cytoplasm Source: MGI
  4. early endosome Source: MGI
  5. extracellular space Source: Ensembl
  6. extracellular vesicular exosome Source: Ensembl
  7. extrinsic component of plasma membrane Source: MGI
  8. late endosome membrane Source: Ensembl
  9. lipid particle Source: Ensembl
  10. lysosomal membrane Source: Ensembl
  11. macropinosome Source: Ensembl
  12. membrane raft Source: Ensembl
  13. midbody Source: Ensembl
  14. nucleus Source: Ensembl
  15. perinuclear region of cytoplasm Source: Ensembl
  16. protein complex Source: Ensembl
  17. ruffle Source: Ensembl
  18. sarcolemma Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ542G9.

Family & Domainsi

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation
Contains 4 annexin repeats.UniRule annotation
Contains annexin repeats.SAAS annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118972.
HOVERGENiHBG061815.
KOiK17092.
OMAiFIQQDTK.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q542G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG
60 70 80 90 100
VDEVTIVNIL TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL
110 120 130 140 150
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM
160 170 180 190 200
YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARELYD
210 220 230 240 250
AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG
260 270 280 290 300
DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM
310 320 330
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
Length:339
Mass (Da):38,676
Last modified:May 24, 2005 - v1
Checksum:i4407E572097FB2C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088645 mRNA. Translation: BAC40474.1.
AK146096 mRNA. Translation: BAE26899.1.
AK152561 mRNA. Translation: BAE31314.1.
AK164507 mRNA. Translation: BAE37816.1.
AK165888 mRNA. Translation: BAE38439.1.
AK167894 mRNA. Translation: BAE39905.1.
AK168083 mRNA. Translation: BAE40056.1.
CH466522 Genomic DNA. Translation: EDL26171.1.
CH466522 Genomic DNA. Translation: EDL26172.1.
CH466522 Genomic DNA. Translation: EDL26173.1.
RefSeqiNP_031611.1. NM_007585.3.
XP_006510859.1. XM_006510796.1.
UniGeneiMm.238343.

Genome annotation databases

GeneIDi12306.
KEGGimmu:12306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088645 mRNA. Translation: BAC40474.1 .
AK146096 mRNA. Translation: BAE26899.1 .
AK152561 mRNA. Translation: BAE31314.1 .
AK164507 mRNA. Translation: BAE37816.1 .
AK165888 mRNA. Translation: BAE38439.1 .
AK167894 mRNA. Translation: BAE39905.1 .
AK168083 mRNA. Translation: BAE40056.1 .
CH466522 Genomic DNA. Translation: EDL26171.1 .
CH466522 Genomic DNA. Translation: EDL26172.1 .
CH466522 Genomic DNA. Translation: EDL26173.1 .
RefSeqi NP_031611.1. NM_007585.3.
XP_006510859.1. XM_006510796.1.
UniGenei Mm.238343.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12306.
KEGGi mmu:12306.

Organism-specific databases

CTDi 302.
MGIi MGI:88246. Anxa2.

Phylogenomic databases

GeneTreei ENSGT00760000118972.
HOVERGENi HBG061815.
KOi K17092.
OMAi FIQQDTK.

Miscellaneous databases

NextBioi 280840.
SOURCEi Search...

Gene expression databases

Genevestigatori Q542G9.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view ]
PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and PlacentaImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and LungImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ542G9_MOUSE
AccessioniPrimary (citable) accession number: Q542G9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)