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Protein

Annexin

Gene

Anxa2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: MGI
  2. calcium-dependent protein binding Source: MGI
  3. calcium ion binding Source: InterPro
  4. phosphatidylinositol-4,5-bisphosphate binding Source: MGI
  5. phospholipase A2 inhibitor activity Source: MGI
  6. poly(A) RNA binding Source: MGI
  7. S100 protein binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. body fluid secretion Source: Ensembl
  3. collagen fibril organization Source: MGI
  4. fibrinolysis Source: MGI
  5. membrane budding Source: MGI
  6. membrane raft assembly Source: MGI
  7. negative regulation of catalytic activity Source: MGI
  8. osteoclast development Source: MGI
  9. positive regulation of binding Source: MGI
  10. positive regulation of fibroblast proliferation Source: Ensembl
  11. positive regulation of protein phosphorylation Source: Ensembl
  12. positive regulation of vesicle fusion Source: MGI
  13. protein heterotetramerization Source: MGI
  14. protein targeting to plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:Anxa2Imported
ORF Names:mCG_5731Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88246. Anxa2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. cell surface Source: MGI
  3. cytoplasm Source: MGI
  4. early endosome Source: MGI
  5. endosome Source: MGI
  6. extracellular space Source: MGI
  7. extracellular vesicular exosome Source: MGI
  8. extrinsic component of plasma membrane Source: MGI
  9. late endosome membrane Source: MGI
  10. lipid particle Source: MGI
  11. lysosomal membrane Source: MGI
  12. macropinosome Source: Ensembl
  13. membrane Source: MGI
  14. membrane raft Source: Ensembl
  15. midbody Source: MGI
  16. nucleus Source: MGI
  17. perinuclear region of cytoplasm Source: Ensembl
  18. plasma membrane Source: MGI
  19. protein complex Source: Ensembl
  20. ruffle Source: Ensembl
  21. sarcolemma Source: MGI
  22. vesicle Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ542G9.

Structurei

3D structure databases

ProteinModelPortaliQ542G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation
Contains 4 annexin repeats.UniRule annotation
Contains annexin repeats.SAAS annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118972.
HOVERGENiHBG061815.
KOiK17092.
OMAiIAFAYER.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q542G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG
60 70 80 90 100
VDEVTIVNIL TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL
110 120 130 140 150
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM
160 170 180 190 200
YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARELYD
210 220 230 240 250
AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG
260 270 280 290 300
DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM
310 320 330
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
Length:339
Mass (Da):38,676
Last modified:May 24, 2005 - v1
Checksum:i4407E572097FB2C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088645 mRNA. Translation: BAC40474.1.
AK146096 mRNA. Translation: BAE26899.1.
AK152561 mRNA. Translation: BAE31314.1.
AK164507 mRNA. Translation: BAE37816.1.
AK165888 mRNA. Translation: BAE38439.1.
AK167894 mRNA. Translation: BAE39905.1.
AK168083 mRNA. Translation: BAE40056.1.
CH466522 Genomic DNA. Translation: EDL26171.1.
CH466522 Genomic DNA. Translation: EDL26172.1.
CH466522 Genomic DNA. Translation: EDL26173.1.
RefSeqiNP_031611.1. NM_007585.3.
XP_006510859.1. XM_006510796.1.
UniGeneiMm.238343.

Genome annotation databases

GeneIDi12306.
KEGGimmu:12306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088645 mRNA. Translation: BAC40474.1.
AK146096 mRNA. Translation: BAE26899.1.
AK152561 mRNA. Translation: BAE31314.1.
AK164507 mRNA. Translation: BAE37816.1.
AK165888 mRNA. Translation: BAE38439.1.
AK167894 mRNA. Translation: BAE39905.1.
AK168083 mRNA. Translation: BAE40056.1.
CH466522 Genomic DNA. Translation: EDL26171.1.
CH466522 Genomic DNA. Translation: EDL26172.1.
CH466522 Genomic DNA. Translation: EDL26173.1.
RefSeqiNP_031611.1. NM_007585.3.
XP_006510859.1. XM_006510796.1.
UniGeneiMm.238343.

3D structure databases

ProteinModelPortaliQ542G9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12306.
KEGGimmu:12306.

Organism-specific databases

CTDi302.
MGIiMGI:88246. Anxa2.

Phylogenomic databases

GeneTreeiENSGT00760000118972.
HOVERGENiHBG061815.
KOiK17092.
OMAiIAFAYER.

Miscellaneous databases

ChiTaRSiAnxa2. mouse.
NextBioi280840.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ542G9.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and PlacentaImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and LungImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported, C57BL/6JImported, DBA/2Imported and NODImported.
    Tissue: Bone marrowImported, HeartImported, LungImported, PlacentaImported and ThymusImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ542G9_MOUSE
AccessioniPrimary (citable) accession number: Q542G9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: February 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.