Q542G9 (Q542G9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Annexin RuleBase RU003540

Gene names

Name:	Anxa2 MGI 88246 EMBL EDL26171.1
ORF Names:	mCG_5731 EMBL EDL26171.1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Domain	A pair of annexin repeats may form one binding site for calcium and phospholipid By similarity. RuleBase RU003540
Sequence similarities	Belongs to the annexin family. RuleBase RU003540 Contains 4 annexin repeats. RuleBase RU003540

Ontologies

Keywords
Domain	Annexin SAAS SAAS018502 RuleBase RU003540 Repeat SAAS SAAS018502 RuleBase RU003540
Ligand	Calcium Calcium/phospholipid-binding RuleBase RU003540
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from mutant phenotype PubMed 14702107. Source: MGI body fluid secretion Inferred from electronic annotation. Source: Compara cellular response to acid Inferred from direct assay PubMed 17690254. Source: MGI collagen fibril organization Inferred from mutant phenotype PubMed 14702107. Source: MGI fibrinolysis Inferred from mutant phenotype PubMed 14702107. Source: MGI positive regulation of binding Inferred from mutant phenotype PubMed 17690254. Source: MGI positive regulation of vesicle fusion Inferred from electronic annotation. Source: Compara
Cellular_component	early endosome Inferred from direct assay PubMed 15078881. Source: MGI extrinsic to plasma membrane Inferred from direct assay PubMed 17690254. Source: MGI lipid particle Inferred from electronic annotation. Source: Compara midbody Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara sarcolemma Inferred from direct assay PubMed 14506282. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro calcium-dependent phospholipid binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol-4,5-bisphosphate binding Inferred from electronic annotation. Source: Compara phospholipase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q542G9 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 4407E572097FB2C0	FASTA	339	38,676
	10 20 30 40 50 60 MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG VDEVTIVNIL 70 80 90 100 110 120 TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 130 140 150 160 170 180 LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA 190 200 210 220 230 240 EDGSVIDYEL IDQDARELYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM 250 260 270 280 290 300 LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 310 320 330 LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1. Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1. Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1. Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1. Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1. Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[6]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL26171.1.
[7]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAC40474.1. Tissue: Thymus EMBL BAC40474.1.
[8]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE26899.1. Tissue: Bone marrow EMBL BAE31314.1 and Placenta EMBL BAE26899.1.
[9]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE37816.1 and DBA/2 EMBL BAE39905.1. Tissue: Heart EMBL BAE37816.1 and Lung EMBL BAE38439.1.
[10]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1. Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[11]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/C EMBL BAE40056.1, C57BL/6J EMBL BAE26899.1, DBA/2 EMBL BAE39905.1 and NOD EMBL BAC40474.1. Tissue: Bone marrow EMBL BAE31314.1, Heart EMBL BAE37816.1, Lung EMBL BAE38439.1, Placenta EMBL BAE26899.1 and Thymus EMBL BAC40474.1.
[12]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL26171.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK088645 mRNA. Translation: BAC40474.1. AK146096 mRNA. Translation: BAE26899.1. AK152561 mRNA. Translation: BAE31314.1. AK164507 mRNA. Translation: BAE37816.1. AK165888 mRNA. Translation: BAE38439.1. AK167894 mRNA. Translation: BAE39905.1. AK168083 mRNA. Translation: BAE40056.1. CH466522 Genomic DNA. Translation: EDL26171.1. CH466522 Genomic DNA. Translation: EDL26172.1. CH466522 Genomic DNA. Translation: EDL26173.1.
IPI	IPI00468203.
RefSeq	NP_031611.1. NM_007585.3.
UniGene	Mm.238343.
3D structure databases
SMR	Q542G9. Positions 32-339.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	12306.
KEGG	mmu:12306.
Organism-specific databases
CTD	302.
MGI	MGI:88246. Anxa2.
Phylogenomic databases
GeneTree	ENSGT00680000099735.
HOVERGEN	HBG061815.
InParanoid	Q542G9.
OMA	FIQQDTK.
Gene expression databases
Genevestigator	Q542G9.
Family and domain databases
Gene3D	1.10.220.10. 4 hits.
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR002389. AnnexinII. [Graphical view]
PANTHER	PTHR10502. PTHR10502. 1 hit. PTHR10502:SF18. PTHR10502:SF18. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR00198. ANNEXINII.
SMART	SM00335. ANX. 4 hits. [Graphical view]
SUPFAM	SSF47874. Annexin. 1 hit.
PROSITE	PS00223. ANNEXIN. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	280840.
SOURCE	Search...

Entry information

Entry name

Q542G9_MOUSE

Accession

Primary (citable) accession number: Q542G9

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	May 29, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)