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Protein
Submitted name:

Polyketide synthase

Gene

rapB

Organism
Streptomyces hygroscopicus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Polyketide synthaseImported
Gene namesi
Name:rapBImported
OrganismiStreptomyces hygroscopicusImported
Taxonomic identifieri1912 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Structurei

3D structure databases

ProteinModelPortaliQ54296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1535 – 160571Acyl carrierInterPro annotationAdd
BLAST
Domaini3170 – 324475Acyl carrierInterPro annotationAdd
BLAST
Domaini5158 – 523275Acyl carrierInterPro annotationAdd
BLAST
Domaini6774 – 684875Acyl carrierInterPro annotationAdd
BLAST
Domaini8409 – 848375Acyl carrierInterPro annotationAdd
BLAST
Domaini10071 – 1014171Acyl carrierInterPro annotationAdd
BLAST

Family and domain databases

Gene3Di1.10.1200.10. 6 hits.
3.40.366.10. 12 hits.
3.40.47.10. 12 hits.
3.40.50.720. 10 hits.
3.90.180.10. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 6 hits.
PF08240. ADH_N. 1 hit.
PF16197. KAsynt_C_assoc. 6 hits.
PF00109. ketoacyl-synt. 6 hits.
PF02801. Ketoacyl-synt_C. 6 hits.
PF08659. KR. 6 hits.
PF00550. PP-binding. 6 hits.
PF14765. PS-DH. 6 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 6 hits.
SM00826. PKS_DH. 6 hits.
SM00829. PKS_ER. 1 hit.
SM00825. PKS_KS. 6 hits.
SM00823. PKS_PP. 6 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 6 hits.
SSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 13 hits.
SSF52151. SSF52151. 12 hits.
SSF53901. SSF53901. 6 hits.
SSF55048. SSF55048. 6 hits.
PROSITEiPS50075. ACP_DOMAIN. 6 hits.
PS00606. B_KETOACYL_SYNTHASE. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54296-1 [UniParc]FASTAAdd to basket

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        10         20         30         40         50
MREDQLLDAL RKSVKENARL RKANTSLRAA MDEPLAIVGM ACRLPGGVSS
60 70 80 90 100
PEDLWRLVES GTDAISGFPA DRGWDVENLY DPDPEAAGKS YCVQGGFLDS
110 120 130 140 150
AGGFDASFFG ISPREALAMD PQQRLVLEAS WEAFERAGIE PGSLRGSDTG
160 170 180 190 200
VFMGAYPGGY GVGADLGGFG ATAGAVSVLS GRVSYFFGLE GPAVTVDTAC
210 220 230 240 250
SSSLVALHQA AYALRQGECS LALVGGVTVM ATPQSFVEFS RQRGLASDGR
260 270 280 290 300
CKAFADSADG TGWAEGAGVL LVERLSDAQR KGHQVLAVVR GSAVNQDGAS
310 320 330 340 350
NGLSAPNGPS QQRVIRAALS NAGLSTAEVD VVEAHGTGTT LGDPIEAQAL
360 370 380 390 400
LATYGQDREQ PLLLGSVKSN LGHTQAAAGV SGVIKMVMAL QHVLVPRTLH
410 420 430 440 450
VDEPSRHVDW TDGAVALVTE NQPWPDMGRP RRAGVSSFGI SGTNAHVILE
460 470 480 490 500
SAPPTQAVDD VPPAEAPVVA SELVPLVISA RTLPALVEYE DRLRAYLAAS
510 520 530 540 550
PGVDVRGVAS TLAVTRSVFE HRAVLLGDDT VTGTTVSDPR VVFVFPGQGS
560 570 580 590 600
QRAGMGEELA AAFPVFARIH QQVWGLLDVP DLEVNETGYA QPALFALQVA
610 620 630 640 650
LFGLLESWGV RPDAVVGHSV GELAAGYVSG LWSLEDACTL VSARARLMQA
660 670 680 690 700
LPPGGVMVAV PVSEDEARAV LGEGVEIAAV NGPSSVVLSG DETAVLQAAA
710 720 730 740 750
ALGKSTRLAT SHAFHSARME PMLEEFRTVA ERLTYQTPRL AMAAGDRVTT
760 770 780 790 800
AEYWVRQVRD TVRFGEQVAS YEDAVFIELG ADRSLARLVD GVAMLHTDHE
810 820 830 840 850
AQAAISALAH LYVNGVTVDW TALLGDAPAT RVLDLPTYAF QHQRYWLEGA
860 870 880 890 900
DRAAAGGHPL LGPAVGLAEA SGVLFTSQVS RSGDLWLQDQ TVLPATAFAE
910 920 930 940 950
MALAAADETG CGLVEELTVE ALLLLPDDGA VQVQTWVSEP DDAGRRQLSI
960 970 980 990 1000
HARYSDDELW TRLATATLAT TTGRVSGWQA GEAWPPAGAV PVEARVPSLR
1010 1020 1030 1040 1050
GVWRRGSEVF AEVALDDTHD ATRFLLHPGL MTAAFAAVGE ETPAAWQGLT
1060 1070 1080 1090 1100
LHARNAAELR VRLTSQDDET LSVEAVDSTG LPVLTARSLA LDAVPVNEPA
1110 1120 1130 1140 1150
TSATDLLTLT WAGIATRQQQ TGLTVGAFED LAADGDAPVP DVVVFTALPG
1160 1170 1180 1190 1200
NDDPLAQTRI LTAQVLRTVQ EWIGGERFSD STLVVRTGTG LAAAAVSGLM
1210 1220 1230 1240 1250
RSAQSEHPGR FILVESDDDA LTPDQLAATV GLDEPRLRIS DGRYEVPRLT
1260 1270 1280 1290 1300
RAHADEPEPE RAWDPDGTVL ITGGSGVLAG IVARHLVAER GVRHLLLLSR
1310 1320 1330 1340 1350
GTPDRALLSE LAELGAAVDT AACDVSDRAE LARVLARVSP EHPLTAVIHT
1360 1370 1380 1390 1400
AGVVDDGVVE SLSAQRLETV FRPKADGAWH LHELTRDADL AAFVMYSSAA
1410 1420 1430 1440 1450
GVMAGAGQGN YAAANAFLDA LAEERRAEGL PALAVAWGLW EDASGLTAQL
1460 1470 1480 1490 1500
TDTDRDRIRR GGLRAISAEH GMRLFDNASR HSEPVLVAAP MEPVRDAEVP
1510 1520 1530 1540 1550
ALLRSLHRPN VRRAALAGGA QWLAALAPEE RAKALLKVVR DTAATVLGHA
1560 1570 1580 1590 1600
DARTIPVTGA FRDLGIDSLT AVELRNGLAK VTGLRLPATL VFDYPTPAVL
1610 1620 1630 1640 1650
AARLGELFTG ENPVLVRTAS VVGQDEPLAI VGMACRLPGG VSSPEDLWRL
1660 1670 1680 1690 1700
VESGTDAISG FPADRGWDAE SLFDPDPDAV GKSYCVEGGF LDSAASFDAG
1710 1720 1730 1740 1750
FFGISPREAL AMDPQQRLIM EVSWEAFERA GIEPGSVRGS DTGVFMGAYA
1760 1770 1780 1790 1800
GGYGAGADLG GFAATASATS VLSGRVSYFF GLEGPAITVD TACSSSLVAL
1810 1820 1830 1840 1850
YQAGYALRQG ECSLALVGGV TVMATPQSFV EFSRKSGLDS DGRCKAFADS
1860 1870 1880 1890 1900
ADGTGWAEGV GVLLVERLSD AQAKGHQVLA VVRSSAVNQD GASNGLSAPN
1910 1920 1930 1940 1950
GPSQQGVIRQ ALANAGLTTA EVDVVEAHGT GTTLGDPIEA QAVIATYGQD
1960 1970 1980 1990 2000
RERPLLLGSL KSNIGHAQAA SGVSGVIKMV MALQHNTVPR TLHVDEPSRH
2010 2020 2030 2040 2050
VDWAAGAVEL VRENQPWPGT DRPRRAGVSS FGVSGTNAHV ILESAPPAQP
2060 2070 2080 2090 2100
AEEAQPVETP VVASDVLPLV ISAKTQPALT EHEDRLRAYL AASPGVDTRA
2110 2120 2130 2140 2150
VASTLAVTRS VFEHRAVLLG DDTVTGTAVS DPRVVFVFPG QGWQWLGMGS
2160 2170 2180 2190 2200
ALRDSSIVFA ERMAECAPAL REFVDWDLFT VLDDPAVVDR VDVVQPASWR
2210 2220 2230 2240 2250
MMVSLAAVWQ AAGVRPDAVI GHSQGEIAAA CVAGAVSMRD AARIVTLRSE
2260 2270 2280 2290 2300
AIARGLAGRG AMASVALPAQ DVELVDGAWI AAHNGPASTV IAGTPEAVDH
2310 2320 2330 2340 2350
VLTAHEARGV RVRRITVDYA SHTPHVELIR DELLDITSDS SSQAPVVPWL
2360 2370 2380 2390 2400
STVDGSWVDS PLDVEYWYRN LREPVGFHPA VGQLQAEGDT VFVEVSASPV
2410 2420 2430 2440 2450
LLQAMDDDVV TVATLRRDDG DATRMLTALA QAYVHGVTVD WPAILGTATT
2460 2470 2480 2490 2500
RVLDLPTYAF QHQRYWLRSV DRAAADGHPL LGTVVDLPAS DGVVLTGRVS
2510 2520 2530 2540 2550
LATHTWLADH AVRGSVLLPG TAFVDLVVRA ADEVESDVVD ELVIETPLLL
2560 2570 2580 2590 2600
PQTGGVQLSV SVGGADESGH RAVMVFSQAD NTDTWTRHVT ATVSTSDSTV
2610 2620 2630 2640 2650
SLPEFASWPP AQARPVSVAD FYDRLAAAGT EYGPAFQGLQ AAWRDGDTVY
2660 2670 2680 2690 2700
AEVVLAEEQA QEAARFAVHP ALLDAAMHAS VLHTPDTDQQ SVRMPFSWNH
2710 2720 2730 2740 2750
VQIRATDTAM LRVAATPTTD GWSVRVADDT GRPVATIGSL VTRPVTADTL
2760 2770 2780 2790 2800
GSAADDLLTL VWTEIPTPQQ SSLSVGRYED LADGDVPVPD VAVYTARPEA
2810 2820 2830 2840 2850
DGSPDPLVQT RTLTAQVLQT AQAWLGGERF TDSTLVVRTG TGLAAAAVSG
2860 2870 2880 2890 2900
LMRSAQSEHP GRFVLVESDD DSLTLHQLAA TVGLDEPRLR VNDGRFEVPR
2910 2920 2930 2940 2950
LARVNAAEPE SETVWDPHGT VLITGGSGVL AGALARHLVT ERGVRHLLLL
2960 2970 2980 2990 3000
SRTTADEGLL NELGELGARV ETADCDVSDR AGLARVLAGV SPEHPLTAVI
3010 3020 3030 3040 3050
QTAGALDDGV LETLTAQRLD TVLRPKADGA WHLHELTRNT GLAAFVMYSS
3060 3070 3080 3090 3100
AAGVMGNPGQ GNLAAATAFL DALADQRRAE GLPALALAWG SSEETSDLIG
3110 3120 3130 3140 3150
LRTISAERGM RLFDSASHRG EPLLMAASLD PARAAEVPAL LRSLRRPVAR
3160 3170 3180 3190 3200
RAASADGGVQ WLAALAPAER EKALLKVVCD SAAVVLGHAD ARTIPVTGAF
3210 3220 3230 3240 3250
KDLGVDSLTA VELRNSLVKA TGLRLPATMV FDYPTPTALA ARLDELFTGE
3260 3270 3280 3290 3300
NPAPVREPVP AVAQDEPLAI VGMACRLPGG VSSPEDLWRL VESGTDAVSG
3310 3320 3330 3340 3350
FPTDRGWDVE GLFDPDPDAA GKSYRAEGGF LDTAAGFDAG FFGISPREAL
3360 3370 3380 3390 3400
AMDPQQRLLL EVSWEAFERA GIEPGSVRGS DTGVFIGAFP VGYGAGAARE
3410 3420 3430 3440 3450
GYGATAAPNV LSGRLSYFFG LEGPAITMDT ACSSSLVALH LAAQALRNGE
3460 3470 3480 3490 3500
CSMALAGGVT VMATPEVFTE FARQRGLASD GRCKAFADSA DGAGFSEGAG
3510 3520 3530 3540 3550
LLLVERLSDA RRNGHQVLAV VRGSAVNQDG ASNGFTAPNG PAQQRVIRQA
3560 3570 3580 3590 3600
LANAGLTTAE VDVVEAHGTG TTLGDPIEAQ AVIATYGQDR EQPLLLGTLK
3610 3620 3630 3640 3650
SNVGHTQAAA GVSGVIKMVM ALQHSTVPRT LHVNEPSRHV DWSAGAVELV
3660 3670 3680 3690 3700
TENQSWPVTG RPRRAGVSAF GVSGTNAHVV LESAPPAQSV NNAQPVATPV
3710 3720 3730 3740 3750
VASELVPLVI SAKTLPALTE HEDRLRAYLA ASPGADMRAV GSTLALTRSV
3760 3770 3780 3790 3800
FEHRAVLLGH DTVTVTGTGT AVSNPRVVFV FPGQGWQWLG MGSALRGSSV
3810 3820 3830 3840 3850
VFAERMAECA AALSEFVDWD LFAVLDDPAV VDRVDVVQPA SWAVMVSLAA
3860 3870 3880 3890 3900
VWQADGVRPD AVIGHSQGEI AAACVAGAVS LRDAARSVTL RSQAIARGLA
3910 3920 3930 3940 3950
GRGAMASVAL PAHEIELVDG AWIAAHNGPA STVVAGAPEA VDRVLAVHEA
3960 3970 3980 3990 4000
RGVRVRRIAV DYASHTPHVE LIRDELLDIT AGIGSQAPVV PWLSTVDGTW
4010 4020 4030 4040 4050
VEGPLDVEYW YRNLREPVGF DSAVGQLRAE GDTVFVEVSA SPVLLQAMDD
4060 4070 4080 4090 4100
DVVTVATLRR DDGDATRMLT ALAQAFVEGV TVDWPAILGT ATTRVPDLPT
4110 4120 4130 4140 4150
YAFQHQRFWA EGADRSVAGG HPLLGVAVEL PESDGVLLTG RVSLATHAWL
4160 4170 4180 4190 4200
ADHAVRGSVL LPGTGFVELV VRAADEVGCD VVDELVIETP LLLPSSASVH
4210 4220 4230 4240 4250
LSVSVGEADE SGRRGVTVFS RADGADAWTR HVSATIGVSG AALSLPELAA
4260 4270 4280 4290 4300
WPPAQAQPVG LGDFYDRLTG AGYEYGPAFQ GLQAAWRDGD TVFAEVALAE
4310 4320 4330 4340 4350
EQAEEAARFA VHPALLDAAL DAGILNTLDN AEQGVRLPFS WNGVQVRATG
4360 4370 4380 4390 4400
SATLRVADNP TSDGWSVRVA DDSGRPVATV DSLVTRPVTA DTLGSAADDL
4410 4420 4430 4440 4450
LTVVWTEIPT PQQTGLSVGR FEDLADGDVP VPEVVVCTAL PDSSENPLAP
4460 4470 4480 4490 4500
LDPPDPLVQT RTLTTQVLQA VQAWLAGERF TDSTLVVRTG TGLATAGVSG
4510 4520 4530 4540 4550
LMRSAQSEHP GRFVLVECDD NLTLQQLAAT VGLDEPRLRV CDGRFEVPRL
4560 4570 4580 4590 4600
ARANTPESSP LTIPGDRAWL LEQSHSGTLR DLALVPAETA ERPLQSGEVR
4610 4620 4630 4640 4650
VDVRAAGLNF RDVLIALGTY PGEAVIGAEA AGVVLEVGPE VQDLAPGDRV
4660 4670 4680 4690 4700
FGLVGGGFGA VAIADRRMLG VIPDGWSFTT AASVPVVFAT AYYGLVDLAG
4710 4720 4730 4740 4750
LSAGESVLIH AAAGGVGMAA TQIARHLGAR IYATASTGKQ HVLREAGLED
4760 4770 4780 4790 4800
ARIGDSRTTG FREMVLDTTD SRGVDVVLNS LSGDFVDASL DLLPRGGRFV
4810 4820 4830 4840 4850
EMGKTDIRDP HQVTADRPGT SYQAFDLMDA GPDRLREIIA DLLALFAQGV
4860 4870 4880 4890 4900
LLPLPVRAWD IRQAREAFSW MSRARHIGKI VLTVPQQLDA NGTVLVTGGS
4910 4920 4930 4940 4950
GVLAGIAARH LVAEQGVRHL LLLSRSTPDD ALINELGELG ARVDTAICDV
4960 4970 4980 4990 5000
SDRAGLARIL AGVSPEHPLT AVIHTAGALD DGVVESLTAQ QLETVLRPKA
5010 5020 5030 5040 5050
DGAWHLHELT RDADLAAFVM YSSAAGVLGS GGQGNYAAAN AFLDALAEQR
5060 5070 5080 5090 5100
RGEGLPALAV AWGLWEDASG LTAEMTDTDR DRIRRGGLRA ISAGHGMGLL
5110 5120 5130 5140 5150
DAASRHGEPV LLAAAMEPVR EAEVPALLRL LHRPVARRAA STGGSSVQWL
5160 5170 5180 5190 5200
ARLAPVEREK ALLKLVCDGA ATVLGHADAS TIPATAAFKD LGIDSLTAVE
5210 5220 5230 5240 5250
LRNSLTKATG LRLPATLVFD YPTPTALAAR LGEWFVGETP VPVRTSVSVV
5260 5270 5280 5290 5300
AQDEPLAIVG MACRLPGGVS SPEDLWRLLE SGTDAVSGFP TDRGWDVENL
5310 5320 5330 5340 5350
FGPAAGDSYR LQGGFLDAAA GFDASFFGIS PREALAMDPQ QRLVLEVSWE
5360 5370 5380 5390 5400
AFERAGIEPG SVRGTDTGVF MGAYPGGYGI GADLGGFGAT ASAVSVLSGR
5410 5420 5430 5440 5450
VSYFFGLEGP AITVDTACSS SLVALHQAGY ALRQGECSLA LVGGVTVMAT
5460 5470 5480 5490 5500
PQTFVEFARQ GGLAGDGRSK AFADSADGAG FSEGVGVLLV ERLSDAQAKG
5510 5520 5530 5540 5550
HQVLAMLRSS AVNQDGASNG LTAPNGPSQQ RVIQAALSNA GLAAHEVDVV
5560 5570 5580 5590 5600
EAHGTGTTLG DPIEAQALLA TYGQDREQPL LLGSVKSNLG HTQAAAGVSG
5610 5620 5630 5640 5650
VIKMVMALQR GFVPRTLHVD EPSRHVDWSA GAVALVTENQ PWPDMGRARR
5660 5670 5680 5690 5700
AGVSSFGISG TNAHVILESA PPTQPADNAV IERAPEWLPM VISARTQSAL
5710 5720 5730 5740 5750
TEHEGRLRAY LAASPGVDMR AVASTLAITR SVFEHRAVLL GDDTVTGTAA
5760 5770 5780 5790 5800
TDPRVVFVFP GQGSQRAGMG EELAAAFPVF ARIHQQVWDL LDVPDLEVNE
5810 5820 5830 5840 5850
TGYAQPALFA LQVALFGLLE SWGVRPDAVV GHSVGELAAG YVSGLWSLED
5860 5870 5880 5890 5900
ACTLVSARAR LMQALPAGGV MVAVPVSEDE ARAVLGEGVE IAAVNGPSSV
5910 5920 5930 5940 5950
VLSGDEAAVL QAAEGLGKWT RLATSHAFHS ARMEPMLEEF RAVAEGLTYR
5960 5970 5980 5990 6000
TPQVSMAAGD QLTTTEYWVR QVRDTVRFGE QVASYEDAVF VELGADRSLA
6010 6020 6030 6040 6050
RLVDGVAMLH GDHEAQAAVS ALAHLYVNGV TVDWPALLGD APATRVLDLP
6060 6070 6080 6090 6100
TYAFQHQRYW LEGTDRMAAG GHPLLGEAVA VPGSDGVLLT GRVSLATHPW
6110 6120 6130 6140 6150
LADHAVRGSV LLPGTGFVEL VVRAADEVGC DVIDELVIET PLLLPQTGGV
6160 6170 6180 6190 6200
QLSVAVAESD DSGRRAVTVF SRADNVDTWT RHATVTVSNS DTTLSLPDLS
6210 6220 6230 6240 6250
AWPPAQAQPV NVADFYDQLT VVAYEYGPAF QGLQAAWRDG DTVHAEVALA
6260 6270 6280 6290 6300
EEQAQDAARN AVHPALLDAA LHAGILNTPD TEQGVRLPFS WNQVQVHAVG
6310 6320 6330 6340 6350
SAMLRVAVTQ AADGWSVRVA DDTGRPVATI GSLVTRPVTA DTLGSTTDDL
6360 6370 6380 6390 6400
LALTWTEIPA PQETSLTIGR FEDLADADVP VPEVVVFTAR PDSSENPLAQ
6410 6420 6430 6440 6450
TRTLTAQVLQ KIQAWLAEER FTDSTLIVRI GTGLAAAAVS GLMRSGQSEH
6460 6470 6480 6490 6500
PGRFVLVESD DDTLAPDQLA ATVELDEPRL RISDGRFEVP RLTRTHAAEP
6510 6520 6530 6540 6550
ESEKVWDPDG TVLITGGSGV LAGIAARHLV AERGVRHLLL LSRSAPDGAL
6560 6570 6580 6590 6600
ISELGELGAQ VATAVCDVSD RPGLVRVLAD VSPEHPLTAV IHTAGVVDDG
6610 6620 6630 6640 6650
VVESLTAQRL DTVLRPKADG AWHLHELTRD ADLAAFVMYS SAAGVFGSAG
6660 6670 6680 6690 6700
QGNYAVANAF LDALAEQRRA EGLPALALAW GLWEGTSGLT ANLTDTDHDR
6710 6720 6730 6740 6750
IRRSGMRAIS AEHGMRLFDG ASRRRDPVLV AAAMEPVREA EVPAMLRSLH
6760 6770 6780 6790 6800
RPVARRAASG GAVRCLAALA PEERAKALVK VVCDSAATVL GHADVDSIPV
6810 6820 6830 6840 6850
TAAFRDLGVD SLTAVELRNS LTKATGLRLP ATLVFDYPTP GALAARLEEL
6860 6870 6880 6890 6900
FTGENPVQVR TPVSAVGQDE PLAIVGMACR LPGGVSSPED LWRLVESGTD
6910 6920 6930 6940 6950
AISGFPTDRG WDVENLFDSD PDAAGKSYCV EGGFLATAAN FDASFFGISP
6960 6970 6980 6990 7000
REALAMDPQQ RLVLEVSWEA FERAGIEPGS VRGSDTGVFM GAFPGGYGIG
7010 7020 7030 7040 7050
ADLEGYGATA GLNVLSGRLS YFFGLEGPAV TVDTACSSSL VALHQAGYAL
7060 7070 7080 7090 7100
RQGECSLALI GGVTVMATPH TFVEFSRQRG LASDGRCKAF ADSADGTGWS
7110 7120 7130 7140 7150
EGVGVLLVER LSDAQAKGHQ VLAVVRSSAV NQDGASNGLS APNGPSQQRV
7160 7170 7180 7190 7200
IRQALANAGL TTAEVDVVEA HGTGTTLGDP IEAQAVIATY GQDRDQPVLL
7210 7220 7230 7240 7250
GSVKSNVGHT QAAAGVSGVI KMVMALQHGL VPRTLHVDEP SRHVDWTDGA
7260 7270 7280 7290 7300
VELVTENQSW PEAGRPRRAG VSSFGVSGTN AHVILESAPP TQAVDDVRPA
7310 7320 7330 7340 7350
DAPVVASVMA SELVPLVISA KTQSALAEYE GRLRAYLAAS PGVDMRAVAS
7360 7370 7380 7390 7400
TLAMTRSVFE HRAVIVGDDT VSGTAATDPR VVFVFPGQGS QRAGMGAELA
7410 7420 7430 7440 7450
AAFPVFARIH QQVWDLLDVP DLEVNETGYA QPALFALQVA LFGLLESWGV
7460 7470 7480 7490 7500
RPDAVIGHSV GELAAAYVSG LWSLEDACTL VSARARLMQA LPAGGVMVAV
7510 7520 7530 7540 7550
PVSEDEARAV LGEGVEIAAV NGPSSVVLSG DEAAVLQAAE GLGKWTRLAT
7560 7570 7580 7590 7600
SHAFHSARME PMLEEFRAVA QGLTYHAPGV VMAAGDRVMT AEYWVRQVRD
7610 7620 7630 7640 7650
TVRFGEQVAS YEDAVFVELG ADRSLARLVD GVAMLHGDHE TQAAIGALAH
7660 7670 7680 7690 7700
LYVNGVTVDW TALLGDVPVT RVLDLPTYAF QQQRYWAEVG RSADVSGAGL
7710 7720 7730 7740 7750
DAVGHPLLGA VVALPGSDGV LLTGRVSLAT HAWLADHAVR GSVLLPGTGF
7760 7770 7780 7790 7800
VELVVRAADE VGCDVVDELI VEAPLLLPQT GGVQVSVSVG EADESGHRVV
7810 7820 7830 7840 7850
TIFSRADNAD TWVRHVSAVI STSDSTVSLS EFASWPPAQA QPVDVTGFYD
7860 7870 7880 7890 7900
PLMAEGYEYG PAFQGLQAAW RYGDTVFAEV ALAEEQVREA ARYPSVHPAL
7910 7920 7930 7940 7950
LDAALHACTL ECADAEVGVG LPFSWDGVRV HAGGSAMLRV AVTQAADGWS
7960 7970 7980 7990 8000
VRVADEIGRP VANVGSLVTR PVTADALGSA ADDLLALTWA EIPAPEGTGL
8010 8020 8030 8040 8050
TVGRFEELVS DGDVPVPEVA VFTALPDNDD DPLEQTRKLT GQVLQAVQEW
8060 8070 8080 8090 8100
LGGERFSDST LVVRTGTGLA AAGVSGLMRS AQSEHPGRFV LVESDDDALA
8110 8120 8130 8140 8150
LDQLAAAVGL DEPRLRISDG RFEAPRLTRT HAAEPESEKV WDPDGTVLIT
8160 8170 8180 8190 8200
GGSGVLAGIA VRHLVTERGV RHLLLLSRSA PDEALINQLG ELGARVETAA
8210 8220 8230 8240 8250
CDVSDRAALA QVLAGVSPEH PLTAVIHTAG VLDDGVVESL TAQRLDAVLR
8260 8270 8280 8290 8300
PKADGAWNLH ELTRDADLAA FVMYSSAAGV LGSGGQGNYA AANAFLDALA
8310 8320 8330 8340 8350
EQRHAEGLPA LAVAWGLWED ASGLTAQLTD TDRDRIRRGG LRAISAEHGM
8360 8370 8380 8390 8400
GLFDSASRHS EPVLVAAPME PVRDAEVPAL LRSLHRPVAR RAAAAGGARW
8410 8420 8430 8440 8450
LAALAPAERE KALLKLVSDG AATVLGHADT STIPATTAFK DLGIDSLTAV
8460 8470 8480 8490 8500
ELRNSLAKAT ELRLPATLVF DYPTPTALAA RLDELFTGEN PAPVRGPVSA
8510 8520 8530 8540 8550
VAQDEPLAIV GMACRLPGGV SSPEDLWRLV ESGTDAISGF PTDRGWDVEN
8560 8570 8580 8590 8600
LYDPDPDAPG KSYSVQGGFL DAAAGFDASF FGISPREALA MDPQQRLMLE
8610 8620 8630 8640 8650
VSWEAFERAG IEPGSVRGSD TGVFIGAYPG GYGIGADLGG FGTTAGAASV
8660 8670 8680 8690 8700
LSGRVSYFFG LEGPAFTVDT ACSSSLVALH QAGYALRQGE CSLALVGGVT
8710 8720 8730 8740 8750
VMPTPQTFVE FSRQRGLSAD GRCKAFADAA DGTGWAEGVG VLLVERLSDA
8760 8770 8780 8790 8800
QANGHQILAV VRSSAVNQDG ASNGLSAPNG PSQQRVIRAA LSNAGLAPHE
8810 8820 8830 8840 8850
VDVVEAHGTG TTLGDPIEAQ AVIATYGQGR GEPLLLGSLK SNVGHTQAAA
8860 8870 8880 8890 8900
GVSGVIKMVM ALQHSMVPRT LHVDEPSRHV DWSAGAVELV AENQPWPETG
8910 8920 8930 8940 8950
RPRRAGVSSF GISGTNAHVI LESAPAQSVG DTAGSTPVLV SELVPLVISA
8960 8970 8980 8990 9000
KTQPALTEHE DRLRAYLAAS PGVDIRAVAS TLAVTRSVFE HRAVLLGDET
9010 9020 9030 9040 9050
VTGTAVSDPR IVFVFPGQGW QWLGMGSALR DSSVVFAERM AECAAALSEF
9060 9070 9080 9090 9100
VDWDLFAVLD DPAVVDRVDV VQPASWAVMV SLAAVWQAAG VRPDAVIGHS
9110 9120 9130 9140 9150
QGEIAAACVA GAVSMRDAAR IVTLRSQAIA RGLAGRGAMA SVALPAQDVE
9160 9170 9180 9190 9200
LVDGAWIAAH NGPASTVIAG TPEAVDHVLT ALRQRGAGAA DHVDYASHTP
9210 9220 9230 9240 9250
HVELIRDELL DITSDSSSQD PLVPWLSTVD GTWVDSPLDG EYWYRNLREP
9260 9270 9280 9290 9300
VGFHPAVSQL QAQGDTVFVE VSASPVLMQA MDDDVVTVAT LRRDDGDATR
9310 9320 9330 9340 9350
MLTALAQAYV HGVTVDWRAV LGDVPATRVL DLPTYAFQHQ RYWAEAGRSA
9360 9370 9380 9390 9400
DVSAAGLDAV GHPLLGAVLA MPGSDGVMLT GRVSLATHAW LADHAVRGSV
9410 9420 9430 9440 9450
LLPGTGFVEL VVRAADEVAC DVVDELIVEA PLLLPQTGGV QLSVSVGEAD
9460 9470 9480 9490 9500
ESGHRAVTVF SRADSADAWV RHVSATVSVS DTTVPTSDLT AWPPAQAKPV
9510 9520 9530 9540 9550
DVAGFYDQLT RAGYEYGPAF QGLQAAWRDG DTVFAEVALA EEQTQDAARF
9560 9570 9580 9590 9600
AVHPAVLDAA LHAGILNTPD ADRDTVRLPF SWNHVQVHVT GSATLRVAMT
9610 9620 9630 9640 9650
RVADGWGVRV ADDIGRPVAT IGSLVTRPVA ADALGSAVDD LFALTWTEIP
9660 9670 9680 9690 9700
VSQQVGVTVG KFEDLADGEV PMPDVVVFTA LPDSGDPLAQ TRRLTAEVLQ
9710 9720 9730 9740 9750
AVQVWLAGER FTDSTLVVRT GTGLAAAAVS GLMRSAQSEH PGRFVLVESD
9760 9770 9780 9790 9800
DDTLTPDQLA ATVGLDEPRL RVIDGRYEAP RLTRTGVAEP EPEGVWDPDG
9810 9820 9830 9840 9850
TVLITGGSGV LAGIAARHLV AERGVRHLLL LSRSAPDEAL ISELAELGAA
9860 9870 9880 9890 9900
VVDTAVCDVS DRAGLARVLA GVSPDHPLTA VIHTAGVLDD GVVESLTARR
9910 9920 9930 9940 9950
LDTVLRPKAD GAWNLHELTR DIDLAAFVMY SSAAGVLGSA GQGNYAVANA
9960 9970 9980 9990 10000
FVDALAEQRR AEGLPALALA WGLWEDASGL TAKLTGTDHD RIRRSGLRTI
10010 10020 10030 10040 10050
TAERGMRLFD IASRQGEPVL VATPMEPVRE VEVPALLRLL HRPVARRAAS
10060 10070 10080 10090 10100
TGDSSAQWLV GLAPEERAKA LLKVVRDSAA TVLGHADARS IPATGAFKDL
10110 10120 10130 10140 10150
GVDSLTAVEL RNSLTKATGL RLPATMVFDY PTPADLAARL GDLMNPRVQS
10160 10170 10180 10190 10200
TTLLAEIDRI EKMFTSVTFD DRQASAIKDR LSSVLNKWQR ISSPEEVSTT
10210 10220
ALSSASASEI LDFIDREFGD PTA
Length:10,223
Mass (Da):1,072,192
Last modified:November 1, 1996 - v1
Checksum:i8631C61BDD4E16EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86780 Genomic DNA. Translation: CAA60459.1.
PIRiT30225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86780 Genomic DNA. Translation: CAA60459.1.
PIRiT30225.

3D structure databases

ProteinModelPortaliQ54296.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1200.10. 6 hits.
3.40.366.10. 12 hits.
3.40.47.10. 12 hits.
3.40.50.720. 10 hits.
3.90.180.10. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 6 hits.
PF08240. ADH_N. 1 hit.
PF16197. KAsynt_C_assoc. 6 hits.
PF00109. ketoacyl-synt. 6 hits.
PF02801. Ketoacyl-synt_C. 6 hits.
PF08659. KR. 6 hits.
PF00550. PP-binding. 6 hits.
PF14765. PS-DH. 6 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 6 hits.
SM00826. PKS_DH. 6 hits.
SM00829. PKS_ER. 1 hit.
SM00825. PKS_KS. 6 hits.
SM00823. PKS_PP. 6 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 6 hits.
SSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 13 hits.
SSF52151. SSF52151. 12 hits.
SSF53901. SSF53901. 6 hits.
SSF55048. SSF55048. 6 hits.
PROSITEiPS50075. ACP_DOMAIN. 6 hits.
PS00606. B_KETOACYL_SYNTHASE. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NRRL 5491Imported.
  2. "Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase."
    Molnar I., Aparicio J.F., Haydock S.F., Khaw L.E., Schwecke T., Konig A., Staunton J., Leadlay P.F.
    Gene 169:1-7(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NRRL 5491Imported.
  3. "Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase."
    Aparicio J.F., Molnar I., Schwecke T., Koenig A., Haydock S.F., Khaw L.E., Staunton J., Leadlay P.F., Staunton J., Leadlay P.F.
    Gene 169:9-16(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NRRL 5491Imported.

Entry informationi

Entry nameiQ54296_STRHY
AccessioniPrimary (citable) accession number: Q54296
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.