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Protein
Submitted name:

DNA cytosine methyltransferase 3b6

Gene

Dnmt3b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei657PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
DNA cytosine methyltransferase 3b6Imported
Submitted name:
MCG10465, isoform CRA_cImported
Gene namesi
Name:Dnmt3bImported
Synonyms:Dnmt3b6Imported
ORF Names:mCG_10465Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1261819 Dnmt3b

PTM / Processingi

Proteomic databases

MaxQBiQ541E5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027478
ExpressionAtlasiQ541E5 baseline and differential

Structurei

3D structure databases

SMRiQ541E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 290PWWPInterPro annotationAdd BLAST59
Domaini428 – 560PHD-typeInterPro annotationAdd BLAST133

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGHW Eukaryota
ENOG410XQ4Y LUCA
HOGENOMiHOG000230875
HOVERGENiHBG051381

Family and domain databases

CDDicd11728 ADDz_Dnmt3b, 1 hit
InterProiView protein in InterPro
IPR025766 ADD
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR030488 DNMT3B_ADD
IPR000313 PWWP_dom
IPR029063 SAM-dependent_MTases
IPR011011 Znf_FYVE_PHD
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51533 ADD, 1 hit
PS00094 C5_MTASE_1, 1 hit
PS50812 PWWP, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

Q541E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGDSRHLNE EEGASGYEEC IIVNGNFSDQ SSDTKDAPSP PVLEAICTEP
60 70 80 90 100
VCTPETRGRR SSSRLSKREV SSLLNYTQDM TGDGDRDDEV DDGNGSDILM
110 120 130 140 150
PKLTRETKDT RTRSESPAVR TRHSNGTSSL ERQRASPRIT RGRQGRHHVQ
160 170 180 190 200
EYPVEFPATR SRRRRASSSA STPWSSPASV DFMEEVTPKS VSTPSVDLSQ
210 220 230 240 250
DGDQEGMDTT QVDAESRDGD STEYQDDKEF GIGDLVWGKI KGFSWWPAMV
260 270 280 290 300
VSWKATSKRQ AMPGMRWVQW FGDGKFSEIS ADKLVALGLF SQHFNLATFN
310 320 330 340 350
KLVSYRKAMY HTLEKARVRA GKTFSSSPGE SLEDQLKPML EWAHGGFKPT
360 370 380 390 400
GIEGLKPNKK QPVVNKSKVR RSDSRNLEPR RRENKSRRRT TNDSAASESP
410 420 430 440 450
PPKRLKTNSY GGKDRGEDEE SRERMASEVT NNKGNLEDRC LSCGKKNPVS
460 470 480 490 500
FHPLFEGGLC QSCRDRFLEL FYMYDEDGYQ SYCTVCCEGR ELLLCSNTSC
510 520 530 540 550
CRCFCVECLE VLVGAGTAED AKLQEPWSCY MCLPQRCHGV LRRRKDWNMR
560 570 580 590 600
LQDFFTTDPD LEEFEPPKLY PAIPAAKRRP IRVLSLFDGI ATGYLVLKEL
610 620 630 640 650
GIKVEKYIAS EVCAESIAVG TVKHEGQIKY VNDVRKITKK NIEEWGPFDL
660 670 680 690 700
VIGGSPCNDL SNVNPARKGL YEGTGRLFFE FYHLLNYTRP KEGDNRPFFW
710 720 730 740 750
MFENVVAMKV NDKKDISRFL ACNPVMIDAI KVSAAHRARY FWGNLPGMNR
760 770 780 790
IFGFPAHYTD VSNMGRGARQ KLLGRSWSVP VIRHLFAPLK DYFACE
Length:796
Mass (Da):90,021
Last modified:May 24, 2005 - v1
Checksum:i0B7D93B4D802744E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078427 mRNA Translation: AAL85481.1
CH466551 Genomic DNA Translation: EDL06034.1
CH466551 Genomic DNA Translation: EDL06039.1
RefSeqiNP_001003963.2, NM_001003963.4
NP_001258675.1, NM_001271746.1
UniGeneiMm.491804
Mm.89772

Genome annotation databases

GeneIDi13436
UCSCiuc008nid.3 mouse

Similar proteinsi

Entry informationi

Entry nameiQ541E5_MOUSE
AccessioniPrimary (citable) accession number: Q541E5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health