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Protein
Submitted name:

Peripheral-type benzodiazepine receptor

Gene

Tspo

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Peripheral-type benzodiazepine receptorImported
Submitted name:
Translocator proteinImported
Gene namesi
Name:TspoImported
Synonyms:BzrpImported
ORF Names:mCG_49242Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88222. Tspo.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei47 – 6620HelicalSequence analysisAdd
BLAST
Transmembranei78 – 9518HelicalSequence analysisAdd
BLAST
Transmembranei107 – 12620HelicalSequence analysisAdd
BLAST
Transmembranei138 – 15518HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

TopDownProteomicsiQ541E3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037039.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3797. Eukaryota.
COG3476. LUCA.
GeneTreeiENSGT00390000012980.
HOVERGENiHBG001296.
KOiK05770.
OMAiNPPDWLF.

Family and domain databases

InterProiIPR030164. TSPO.
IPR004307. TspO_MBR.
[Graphical view]
PANTHERiPTHR10057. PTHR10057. 1 hit.
PTHR10057:SF5. PTHR10057:SF5. 1 hit.
PfamiPF03073. TspO_MBR. 1 hit.
[Graphical view]
PIRSFiPIRSF005859. PBR. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q541E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPESWVPAVG LTLVPSLGGF MGAYFVRGEG LRWYASLQKP SWHPPRWTLA
60 70 80 90 100
PIWGTLYSAM GYGSYIVWKE LGGFTEDAMV PLGLYTGQLA LNWAWPPIFF
110 120 130 140 150
GARQMGWALA DLLLVSGVAT ATTLAWHRVS PPAARLLYPY LAWLAFATVL
160
NYYVWRDNSG RRGGSRLPE
Length:169
Mass (Da):18,841
Last modified:May 24, 2005 - v1
Checksum:i2EF93420C3842A85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583887 Genomic DNA. No translation available.
AY079441 Genomic DNA. Translation: AAL87529.1.
AY079442 Genomic DNA. Translation: AAL87530.1.
AK149743 mRNA. Translation: BAE29056.1.
AK150516 mRNA. Translation: BAE29628.1.
AK151421 mRNA. Translation: BAE30386.1.
AK151569 mRNA. Translation: BAE30511.1.
AK151824 mRNA. Translation: BAE30721.1.
AK152082 mRNA. Translation: BAE30932.1.
AK152827 mRNA. Translation: BAE31528.1.
AK153159 mRNA. Translation: BAE31769.1.
AK153273 mRNA. Translation: BAE31860.1.
AK156489 mRNA. Translation: BAE33730.1.
AK165450 mRNA. Translation: BAE38192.1.
AK165822 mRNA. Translation: BAE38396.1.
AK166125 mRNA. Translation: BAE38585.1.
AK172384 mRNA. Translation: BAE42976.1.
CH466550 Genomic DNA. Translation: EDL04468.1.
RefSeqiNP_033905.3. NM_009775.4.
UniGeneiMm.1508.

Genome annotation databases

EnsembliENSMUST00000047419; ENSMUSP00000037039; ENSMUSG00000041736.
GeneIDi12257.
KEGGimmu:12257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583887 Genomic DNA. No translation available.
AY079441 Genomic DNA. Translation: AAL87529.1.
AY079442 Genomic DNA. Translation: AAL87530.1.
AK149743 mRNA. Translation: BAE29056.1.
AK150516 mRNA. Translation: BAE29628.1.
AK151421 mRNA. Translation: BAE30386.1.
AK151569 mRNA. Translation: BAE30511.1.
AK151824 mRNA. Translation: BAE30721.1.
AK152082 mRNA. Translation: BAE30932.1.
AK152827 mRNA. Translation: BAE31528.1.
AK153159 mRNA. Translation: BAE31769.1.
AK153273 mRNA. Translation: BAE31860.1.
AK156489 mRNA. Translation: BAE33730.1.
AK165450 mRNA. Translation: BAE38192.1.
AK165822 mRNA. Translation: BAE38396.1.
AK166125 mRNA. Translation: BAE38585.1.
AK172384 mRNA. Translation: BAE42976.1.
CH466550 Genomic DNA. Translation: EDL04468.1.
RefSeqiNP_033905.3. NM_009775.4.
UniGeneiMm.1508.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037039.

Proteomic databases

TopDownProteomicsiQ541E3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047419; ENSMUSP00000037039; ENSMUSG00000041736.
GeneIDi12257.
KEGGimmu:12257.

Organism-specific databases

CTDi706.
MGIiMGI:88222. Tspo.

Phylogenomic databases

eggNOGiKOG3797. Eukaryota.
COG3476. LUCA.
GeneTreeiENSGT00390000012980.
HOVERGENiHBG001296.
KOiK05770.
OMAiNPPDWLF.

Miscellaneous databases

NextBioi280682.
SOURCEiSearch...

Family and domain databases

InterProiIPR030164. TSPO.
IPR004307. TspO_MBR.
[Graphical view]
PANTHERiPTHR10057. PTHR10057. 1 hit.
PTHR10057:SF5. PTHR10057:SF5. 1 hit.
PfamiPF03073. TspO_MBR. 1 hit.
[Graphical view]
PIRSFiPIRSF005859. PBR. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported, KidneyImported, LungImported and Ovary and uterusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported, KidneyImported, LungImported and Ovary and uterusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported, KidneyImported, LungImported and Ovary and uterusImported.
  4. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
    Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ILSImported and ISSImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported, KidneyImported, LungImported and Ovary and uterusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported, KidneyImported, LungImported and Ovary and uterusImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ILSImported and ISSImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Bone marrowImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, KidneyImported, LungImported and Ovary and uterusImported.
  11. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported, KidneyImported, LungImported and Ovary and uterusImported.
  12. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported, KidneyImported, LungImported and Ovary and uterusImported.
  13. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Ensembl
    Submitted (AUG-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ541E3_MOUSE
AccessioniPrimary (citable) accession number: Q541E3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.