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Protein
Submitted name:

ATP-binding cassette sub-family G member 5

Gene

Abcg5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi87 – 94ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingPROSITE-ProRule annotationSAAS annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette sub-family G member 5Imported
Submitted name:
ATP-binding cassette, sub-family G (WHITE), member 5Imported
Submitted name:
ATP-binding cassette, sub-family G (WHITE), member 5, isoform CRA_aImported
Submitted name:
Putative uncharacterized proteinImported
Submitted name:
Sterolin-1Imported
Gene namesi
Name:Abcg5Imported
ORF Names:mCG_124964Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1351659. Abcg5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei387 – 406HelicalSequence analysisAdd BLAST20
Transmembranei426 – 444HelicalSequence analysisAdd BLAST19
Transmembranei465 – 491HelicalSequence analysisAdd BLAST27
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Transmembranei625 – 643HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000040505.
ExpressionAtlasiQ540E8. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ540E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 294ABC transporterInterPro annotationAdd BLAST256

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
HOVERGENiHBG050443.
KOiK05683.
OMAiNAVNLFP.
OrthoDBiEOG091G0FOJ.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q540E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELPFLSPE GARGPHINRG SLSSLEQGSV TGTEARHSLG VLHVSYSVSN
60 70 80 90 100
RVGPWWNIKS CQQKWDRQIL KDVSLYIESG QIMCILGSSG SGKTTLLDAI
110 120 130 140 150
SGRLRRTGTL EGEVFVNGCE LRRDQFQDCF SYVLQSDVFL SSLTVRETLR
160 170 180 190 200
YTAMLALCRS SADFYNKKVE AVMTELSLSH VADQMIGSYN FGGISSGERR
210 220 230 240 250
RVSIAAQLLQ DPKVMMLDEP TTGLDCMTAN QIVLLLAELA RRDRIVIVTI
260 270 280 290 300
HQPRSELFQH FDKIAILTYG ELVFCGTPEE MLGFFNNCGY PCPEHSNPFD
310 320 330 340 350
FYMDLTSVDT QSREREIETY KRVQMLECAF KESDIYHKIL ENIERARYLK
360 370 380 390 400
TLPTVPFKTK DPPGMFGKLG VLLRRVTRNL MRNKQAVIMR LVQNLIMGLF
410 420 430 440 450
LIFYLLRVQN NTLKGAVQDR VGLLYQLVGA TPYTGMLNAV NLFPMLRAVS
460 470 480 490 500
DQESQDGLYH KWQMLLAYVL HVLPFSVIAT VIFSSVCYWT LGLYPEVARF
510 520 530 540 550
GYFSAALLAP HLIGEFLTLV LLGIVQNPNI VNSIVALLSI SGLLIGSGFI
560 570 580 590 600
RNIQEMPIPL KILGYFTFQK YCCEILVVNE FYGLNFTCGG SNTSMLNHPM
610 620 630 640 650
CAITQGVQFI EKTCPGATSR FTANFLILYG FIPALVILGI VIFKVRDYLI

SR
Length:652
Mass (Da):73,244
Last modified:May 24, 2005 - v1
Checksum:i80CE37ADCC19771E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106766 mRNA. Translation: AAI06767.1.
AH011511
, AF351786, AF351787, AF351789, AF351790, AF351791, AF351792, AF351793, AF351794, AF351795, AF351796, AF351797 Genomic DNA. Translation: AAL82586.1.
AY195873 mRNA. Translation: AAO45094.1.
AK149569 mRNA. Translation: BAE28965.1.
CH466537 Genomic DNA. Translation: EDL38580.1.
RefSeqiNP_114090.1. NM_031884.2.
UniGeneiMm.289590.

Genome annotation databases

GeneIDi27409.
KEGGimmu:27409.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ540E8_MOUSE
AccessioniPrimary (citable) accession number: Q540E8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 5, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)