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Q540C2

- Q540C2_MOUSE

UniProt

Q540C2 - Q540C2_MOUSE

Protein
Submitted name:

Interferon alpha 4

Gene

Ifna4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. cytokine-mediated signaling pathway Source: RefGenome
    5. defense response to virus Source: MGI
    6. humoral immune response Source: RefGenome
    7. innate immune response Source: RefGenome
    8. natural killer cell activation involved in immune response Source: MGI
    9. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    10. regulation of MHC class I biosynthetic process Source: RefGenome
    11. response to exogenous dsRNA Source: RefGenome
    12. T cell activation involved in immune response Source: RefGenome

    Keywords - Molecular functioni

    CytokineUniRule annotationSAAS annotation

    Keywords - Biological processi

    Antiviral defenseUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interferon alpha 4Imported
    Submitted name:
    MCG123696Imported
    Gene namesi
    Name:Ifna4Imported
    ORF Names:mCG_123696Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:107664. Ifna4.

    Subcellular locationi

    Secreted SAAS annotation

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424 PotentialImportedAdd
    BLAST
    Chaini25 – 186162 PotentialImportedPRO_5001125728Add
    BLAST
    Chaini25 – 186162interferon alpha 4ImportedPRO_5000090351Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ540C2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    GeneTreeiENSGT00590000082966.
    HOVERGENiHBG052086.
    InParanoidiQ540C2.
    KOiK05414.
    OMAiHEGANED.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q540C2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARLCAFLMI LVMMSYYWSA CSLGCDLPHT YNLGNKRALT VLEEMRRLPP    50
    LSCLKDRKDF GFPLEKVDNQ QIQKAQAILV LRDLTQQILN LFTSKDLSAT 100
    WNATLLDSFC NDLHQQLNDL KACVMQEPPL TQEDSLLAVR TYFHRITVYL 150
    RKKKHSLCAW EVIRAEVWRA LSSSTNLLAR LSEEKE 186
    Length:186
    Mass (Da):21,524
    Last modified:May 24, 2005 - v1
    Checksum:iFC5D46D473741794
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC116217 mRNA. Translation: AAI16218.1.
    BC119349 mRNA. Translation: AAI19350.1.
    BC119351 mRNA. Translation: AAI19352.1.
    AY220463 Genomic DNA. Translation: AAO64456.1.
    CH466527 Genomic DNA. Translation: EDL30959.1.
    RefSeqiNP_034634.1. NM_010504.2.
    UniGeneiMm.377088.

    Genome annotation databases

    GeneIDi15967.
    KEGGimmu:15967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC116217 mRNA. Translation: AAI16218.1 .
    BC119349 mRNA. Translation: AAI19350.1 .
    BC119351 mRNA. Translation: AAI19352.1 .
    AY220463 Genomic DNA. Translation: AAO64456.1 .
    CH466527 Genomic DNA. Translation: EDL30959.1 .
    RefSeqi NP_034634.1. NM_010504.2.
    UniGenei Mm.377088.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15967.
    KEGGi mmu:15967.

    Organism-specific databases

    CTDi 3441.
    MGIi MGI:107664. Ifna4.

    Phylogenomic databases

    GeneTreei ENSGT00590000082966.
    HOVERGENi HBG052086.
    InParanoidi Q540C2.
    KOi K05414.
    OMAi HEGANED.

    Miscellaneous databases

    NextBioi 288724.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q540C2.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "Characterization of interferon-alpha 13, a novel constitutive murine interferon-alpha subtype."
      Van Pesch V., Michiels T.
      J. Biol. Chem. 278:46321-46328(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvImported.
    3. "Characterization of mouse alpha interferon subtypes."
      van Pesch V., Lanaya H., Michiels T.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvImported.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported and PCR rescued clonesImported.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ540C2_MOUSE
    AccessioniPrimary (citable) accession number: Q540C2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)