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Q540C2

- Q540C2_MOUSE

UniProt

Q540C2 - Q540C2_MOUSE

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Protein
Submitted name:

Interferon alpha 4

Gene

Ifna4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cytokine activity Source: RefGenome
  2. type I interferon receptor binding Source: RefGenome

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. B cell differentiation Source: RefGenome
  3. B cell proliferation Source: RefGenome
  4. cytokine-mediated signaling pathway Source: RefGenome
  5. defense response to virus Source: MGI
  6. humoral immune response Source: RefGenome
  7. innate immune response Source: RefGenome
  8. natural killer cell activation involved in immune response Source: MGI
  9. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
  10. regulation of MHC class I biosynthetic process Source: RefGenome
  11. response to exogenous dsRNA Source: RefGenome
  12. T cell activation involved in immune response Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation

Keywords - Biological processi

Antiviral defenseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon alpha 4Imported
Submitted name:
MCG123696Imported
Gene namesi
Name:Ifna4Imported
ORF Names:mCG_123696Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:107664. Ifna4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 PotentialImportedAdd
BLAST
Chaini25 – 186162 PotentialImportedPRO_5001125728Add
BLAST
Chaini25 – 186162interferon alpha 4ImportedPRO_5000090351Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ540C2.

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

GeneTreeiENSGT00760000119150.
HOVERGENiHBG052086.
KOiK05414.
OMAiHEGANED.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q540C2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARLCAFLMI LVMMSYYWSA CSLGCDLPHT YNLGNKRALT VLEEMRRLPP
60 70 80 90 100
LSCLKDRKDF GFPLEKVDNQ QIQKAQAILV LRDLTQQILN LFTSKDLSAT
110 120 130 140 150
WNATLLDSFC NDLHQQLNDL KACVMQEPPL TQEDSLLAVR TYFHRITVYL
160 170 180
RKKKHSLCAW EVIRAEVWRA LSSSTNLLAR LSEEKE
Length:186
Mass (Da):21,524
Last modified:May 24, 2005 - v1
Checksum:iFC5D46D473741794
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC116217 mRNA. Translation: AAI16218.1.
BC119349 mRNA. Translation: AAI19350.1.
BC119351 mRNA. Translation: AAI19352.1.
AY220463 Genomic DNA. Translation: AAO64456.1.
CH466527 Genomic DNA. Translation: EDL30959.1.
RefSeqiNP_034634.1. NM_010504.2.
UniGeneiMm.377088.

Genome annotation databases

GeneIDi15967.
KEGGimmu:15967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC116217 mRNA. Translation: AAI16218.1 .
BC119349 mRNA. Translation: AAI19350.1 .
BC119351 mRNA. Translation: AAI19352.1 .
AY220463 Genomic DNA. Translation: AAO64456.1 .
CH466527 Genomic DNA. Translation: EDL30959.1 .
RefSeqi NP_034634.1. NM_010504.2.
UniGenei Mm.377088.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15967.
KEGGi mmu:15967.

Organism-specific databases

CTDi 3441.
MGIi MGI:107664. Ifna4.

Phylogenomic databases

GeneTreei ENSGT00760000119150.
HOVERGENi HBG052086.
KOi K05414.
OMAi HEGANED.

Miscellaneous databases

NextBioi 288724.
SOURCEi Search...

Gene expression databases

Genevestigatori Q540C2.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "Characterization of interferon-alpha 13, a novel constitutive murine interferon-alpha subtype."
    Van Pesch V., Michiels T.
    J. Biol. Chem. 278:46321-46328(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvImported.
  3. "Characterization of mouse alpha interferon subtypes."
    van Pesch V., Lanaya H., Michiels T.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvImported.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported and PCR rescued clonesImported.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ540C2_MOUSE
AccessioniPrimary (citable) accession number: Q540C2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)