Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Adrenal hypoplasia congenita-like protein

Gene

Nr0b1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. AF-2 domain binding Source: MGI
  2. DNA binding Source: MGI
  3. DNA hairpin binding Source: MGI
  4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  5. protein domain specific binding Source: MGI
  6. protein homodimerization activity Source: MGI
  7. RNA binding Source: MGI
  8. sequence-specific DNA binding Source: MGI
  9. steroid hormone receptor activity Source: InterPro
  10. steroid hormone receptor binding Source: MGI
  11. transcription corepressor activity Source: MGI
  12. transcription factor binding Source: MGI

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. cell differentiation Source: MGI
  3. gonad development Source: MGI
  4. intracellular receptor signaling pathway Source: MGI
  5. Leydig cell differentiation Source: MGI
  6. male gonad development Source: MGI
  7. male sex determination Source: MGI
  8. negative regulation of cell differentiation Source: MGI
  9. negative regulation of intracellular steroid hormone receptor signaling pathway Source: MGI
  10. negative regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  11. negative regulation of transcription, DNA-templated Source: MGI
  12. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  13. protein localization Source: MGI
  14. response to immobilization stress Source: MGI
  15. Sertoli cell differentiation Source: MGI
  16. sex determination Source: MGI
  17. spermatogenesis Source: MGI
  18. steroid biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Adrenal hypoplasia congenita-like proteinImported
Submitted name:
Nuclear receptor subfamily 0, group B, member 1Imported
Gene namesi
Name:Nr0b1Imported
ORF Names:mCG_4825Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1352460. Nr0b1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. membrane Source: MGI
  3. nucleus Source: MGI
  4. polysomal ribosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ53ZY9.

Expressioni

Gene expression databases

BgeeiQ53ZY9.
ExpressionAtlasiQ53ZY9. baseline and differential.
GenevestigatoriQ53ZY9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026036.

Structurei

3D structure databases

ProteinModelPortaliQ53ZY9.
SMRiQ53ZY9. Positions 251-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG005453.
KOiK08562.
OMAiCCFCGED.
PhylomeDBiQ53ZY9.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR025900. Nuclear_receptor_repeat.
IPR001723. Str_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF14046. NR_Repeat. 4 hits.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53ZY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEDHPWQG SILYNLLMSA KQKHASQEER EVRLGAQCWG CACGAQPVLG
60 70 80 90 100
GERLSGGQAR SLLYRCCFCG ENHPRQGGIL YSMLTNARQP SVATQAPRAR
110 120 130 140 150
FGAPCWGCAC GSAEPLVGRE GLPAGQAPSL LYRCCFCGEE HPRQGSILYS
160 170 180 190 200
LLTSAQQTHV SREAPEAHRR GEWWQLSYCT QSVGGPEGLQ STQAMAFLYR
210 220 230 240 250
SYVCGEEQPQ QISVASGTPV SADQTPATPQ EQPRAPWWDA SPGVQRLITL
260 270 280 290 300
KDPQVVCEAA SAGLLKTLRF VKYLPCFQIL PLDQQLVLVR SCWAPLLMLE
310 320 330 340 350
LAQDHLHFEM MEIPETNTTQ EMLTTRRQET EGPEPAEPQA TEQPQMVSAE
360 370 380 390 400
AGHLLPAAAV QAIKSFFFKC WSLNIDTKEY AYLKGTVLFN PDLPGLQCVK
410 420 430 440 450
YIEGLQWRTQ QILTEHIRMM QREYQIRSAE LNSALFLLRF INSDVVTELF
460 470
FRPIIGAVSM DDMMLEMLCA KL
Length:472
Mass (Da):52,576
Last modified:May 24, 2005 - v1
Checksum:iDE1FB01C30F883CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227358 Genomic DNA. Translation: AAO47789.1.
AK141239 mRNA. Translation: BAE24608.1.
CH466576 Genomic DNA. Translation: EDL29149.1.
RefSeqiNP_031456.1. NM_007430.4.
UniGeneiMm.5180.

Genome annotation databases

GeneIDi11614.
KEGGimmu:11614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227358 Genomic DNA. Translation: AAO47789.1.
AK141239 mRNA. Translation: BAE24608.1.
CH466576 Genomic DNA. Translation: EDL29149.1.
RefSeqiNP_031456.1. NM_007430.4.
UniGeneiMm.5180.

3D structure databases

ProteinModelPortaliQ53ZY9.
SMRiQ53ZY9. Positions 251-472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026036.

Proteomic databases

PRIDEiQ53ZY9.

Protocols and materials databases

DNASUi11614.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11614.
KEGGimmu:11614.

Organism-specific databases

CTDi190.
MGIiMGI:1352460. Nr0b1.

Phylogenomic databases

HOVERGENiHBG005453.
KOiK08562.
OMAiCCFCGED.
PhylomeDBiQ53ZY9.

Miscellaneous databases

NextBioi279166.
SOURCEiSearch...

Gene expression databases

BgeeiQ53ZY9.
ExpressionAtlasiQ53ZY9. baseline and differential.
GenevestigatoriQ53ZY9.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR025900. Nuclear_receptor_repeat.
IPR001723. Str_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF14046. NR_Repeat. 4 hits.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Clipsham R.C., Guo A.W., McCabe E.R.B.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJImported.
  8. "Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis."
    Clipsham R., Niakan K., McCabe E.R.
    Gene Expr. Patterns 4:3-14(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ53ZY9_MOUSE
AccessioniPrimary (citable) accession number: Q53ZY9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 1, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.