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Q53ZY9

- Q53ZY9_MOUSE

UniProt

Q53ZY9 - Q53ZY9_MOUSE

Protein
Submitted name:

Adrenal hypoplasia congenita-like protein

Gene

Nr0b1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA hairpin binding Source: Ensembl
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
    3. protein binding Source: MGI
    4. RNA binding Source: Ensembl
    5. sequence-specific DNA binding Source: Ensembl
    6. steroid hormone receptor activity Source: InterPro
    7. transcription corepressor activity Source: MGI

    GO - Biological processi

    1. adrenal gland development Source: MGI
    2. cell differentiation Source: MGI
    3. Leydig cell differentiation Source: MGI
    4. male gonad development Source: MGI
    5. male sex determination Source: MGI
    6. negative regulation of cell differentiation Source: MGI
    7. negative regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
    8. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    9. negative regulation of transcription, DNA-templated Source: MGI
    10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    11. protein localization Source: Ensembl
    12. response to immobilization stress Source: MGI
    13. Sertoli cell differentiation Source: MGI
    14. sex determination Source: MGI
    15. spermatogenesis Source: MGI
    16. steroid biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Adrenal hypoplasia congenita-like proteinImported
    Submitted name:
    Nuclear receptor subfamily 0, group B, member 1Imported
    Gene namesi
    Name:Nr0b1Imported
    ORF Names:mCG_4825Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1352460. Nr0b1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. membrane Source: Ensembl
    3. nucleus Source: MGI
    4. polysomal ribosome Source: Ensembl

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ53ZY9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000026036.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG005453.
    InParanoidiQ53ZY9.
    KOiK08562.
    OMAiCCFCGED.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR025900. Nuclear_receptor_repeat.
    IPR001723. Str_hrmn_rcpt.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF14046. NR_Repeat. 4 hits.
    [Graphical view]
    PRINTSiPR00398. STRDHORMONER.
    SMARTiSM00430. HOLI. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q53ZY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGEDHPWQG SILYNLLMSA KQKHASQEER EVRLGAQCWG CACGAQPVLG    50
    GERLSGGQAR SLLYRCCFCG ENHPRQGGIL YSMLTNARQP SVATQAPRAR 100
    FGAPCWGCAC GSAEPLVGRE GLPAGQAPSL LYRCCFCGEE HPRQGSILYS 150
    LLTSAQQTHV SREAPEAHRR GEWWQLSYCT QSVGGPEGLQ STQAMAFLYR 200
    SYVCGEEQPQ QISVASGTPV SADQTPATPQ EQPRAPWWDA SPGVQRLITL 250
    KDPQVVCEAA SAGLLKTLRF VKYLPCFQIL PLDQQLVLVR SCWAPLLMLE 300
    LAQDHLHFEM MEIPETNTTQ EMLTTRRQET EGPEPAEPQA TEQPQMVSAE 350
    AGHLLPAAAV QAIKSFFFKC WSLNIDTKEY AYLKGTVLFN PDLPGLQCVK 400
    YIEGLQWRTQ QILTEHIRMM QREYQIRSAE LNSALFLLRF INSDVVTELF 450
    FRPIIGAVSM DDMMLEMLCA KL 472
    Length:472
    Mass (Da):52,576
    Last modified:May 24, 2005 - v1
    Checksum:iDE1FB01C30F883CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227358 Genomic DNA. Translation: AAO47789.1.
    AK141239 mRNA. Translation: BAE24608.1.
    CH466576 Genomic DNA. Translation: EDL29149.1.
    RefSeqiNP_031456.1. NM_007430.4.
    UniGeneiMm.5180.

    Genome annotation databases

    GeneIDi11614.
    KEGGimmu:11614.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227358 Genomic DNA. Translation: AAO47789.1 .
    AK141239 mRNA. Translation: BAE24608.1 .
    CH466576 Genomic DNA. Translation: EDL29149.1 .
    RefSeqi NP_031456.1. NM_007430.4.
    UniGenei Mm.5180.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000026036.

    Protocols and materials databases

    DNASUi 11614.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11614.
    KEGGi mmu:11614.

    Organism-specific databases

    CTDi 190.
    MGIi MGI:1352460. Nr0b1.

    Phylogenomic databases

    HOVERGENi HBG005453.
    InParanoidi Q53ZY9.
    KOi K08562.
    OMAi CCFCGED.

    Miscellaneous databases

    NextBioi 279166.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q53ZY9.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR025900. Nuclear_receptor_repeat.
    IPR001723. Str_hrmn_rcpt.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF14046. NR_Repeat. 4 hits.
    [Graphical view ]
    PRINTSi PR00398. STRDHORMONER.
    SMARTi SM00430. HOLI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. Clipsham R.C., Guo A.W., McCabe E.R.B.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJImported.
    8. "Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis."
      Clipsham R., Niakan K., McCabe E.R.
      Gene Expr. Patterns 4:3-14(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ53ZY9_MOUSE
    AccessioniPrimary (citable) accession number: Q53ZY9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)