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Protein
Submitted name:

Sphingosine kinase 1

Gene

SPHK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Sphingosine kinase 1Imported
Submitted name:
Sphingosine kinase 1, isoform CRA_aImported
Submitted name:
cDNA FLJ78254Imported
Gene namesi
Name:SPHK1Imported
ORF Names:hCG_30901Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000176170.13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36070

Expressioni

Gene expression databases

BgeeiENSG00000176170

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 159DAGKcInterPro annotationAdd BLAST148

Phylogenomic databases

eggNOGiKOG1116 Eukaryota
COG1597 LUCA
HOVERGENiHBG054796
KOiK04718

Family and domain databases

Gene3Di3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
PfamiView protein in Pfam
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 2 hits
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit

Sequencei

Sequence statusi: Complete.

Q53ZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT
60 70 80 90 100
LMLTERRNHA RELVRSEELG RWDALVVMSG DGLMHEVVNG LMERPDWETA
110 120 130 140 150
IQKPLCSLPA GSGNALAASL NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM
160 170 180 190 200
NLLSLHTASG LRLFSVLSLA WGFIADVDLE SEKYRRLGEM RFTLGTFLRL
210 220 230 240 250
AALRTYRGRL AYLPVGRVGS KTPASPVVVQ QGPVDAHLVP LEEPVPSHWT
260 270 280 290 300
VVPDEDFVLV LALLHSHLGS EMFAAPMGRC AAGVMHLFYV RAGVSRAMLL
310 320 330 340 350
RLFLAMEKGR HMEYECPYLV YVPVVAFRLE PKDGKGVFAV DGELMVSEAV
360 370 380
QGQVHPNYFW MVSGCVEPPP SWKPQQMPPP EEPL
Length:384
Mass (Da):42,518
Last modified:May 24, 2005 - v1
Checksum:iEB04A7F2034C2DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH012828
, AY278522, AY278523, AY278524 Genomic DNA Translation: AAP35060.1
AK292614 mRNA Translation: BAF85303.1
CH471099 Genomic DNA Translation: EAW89388.1
CH471099 Genomic DNA Translation: EAW89389.1
CH471099 Genomic DNA Translation: EAW89390.1
CH471099 Genomic DNA Translation: EAW89391.1
CH471099 Genomic DNA Translation: EAW89394.1
RefSeqiNP_001136073.1, NM_001142601.1
NP_001136074.1, NM_001142602.1
XP_005257823.1, XM_005257766.2
UniGeneiHs.68061

Genome annotation databases

GeneIDi8877
KEGGihsa:8877

Similar proteinsi

Entry informationi

Entry nameiQ53ZR5_HUMAN
AccessioniPrimary (citable) accession number: Q53ZR5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health