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Protein
Submitted name:

Sphingosine kinase 1

Gene

SPHK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Sphingosine kinase 1Imported
Submitted name:
Sphingosine kinase 1, isoform CRA_aImported
Submitted name:
cDNA FLJ78254Imported
Gene namesi
Name:SPHK1Imported
ORF Names:hCG_30901Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36070.

Expressioni

Gene expression databases

BgeeiENSG00000176170.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313681.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 159DAGKcInterPro annotationAdd BLAST148

Phylogenomic databases

eggNOGiKOG1116. Eukaryota.
COG1597. LUCA.
HOVERGENiHBG054796.
KOiK04718.

Family and domain databases

InterProiIPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53ZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT
60 70 80 90 100
LMLTERRNHA RELVRSEELG RWDALVVMSG DGLMHEVVNG LMERPDWETA
110 120 130 140 150
IQKPLCSLPA GSGNALAASL NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM
160 170 180 190 200
NLLSLHTASG LRLFSVLSLA WGFIADVDLE SEKYRRLGEM RFTLGTFLRL
210 220 230 240 250
AALRTYRGRL AYLPVGRVGS KTPASPVVVQ QGPVDAHLVP LEEPVPSHWT
260 270 280 290 300
VVPDEDFVLV LALLHSHLGS EMFAAPMGRC AAGVMHLFYV RAGVSRAMLL
310 320 330 340 350
RLFLAMEKGR HMEYECPYLV YVPVVAFRLE PKDGKGVFAV DGELMVSEAV
360 370 380
QGQVHPNYFW MVSGCVEPPP SWKPQQMPPP EEPL
Length:384
Mass (Da):42,518
Last modified:May 24, 2005 - v1
Checksum:iEB04A7F2034C2DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH012828
, AY278522, AY278523, AY278524 Genomic DNA. Translation: AAP35060.1.
AK292614 mRNA. Translation: BAF85303.1.
CH471099 Genomic DNA. Translation: EAW89388.1.
CH471099 Genomic DNA. Translation: EAW89389.1.
CH471099 Genomic DNA. Translation: EAW89390.1.
CH471099 Genomic DNA. Translation: EAW89391.1.
CH471099 Genomic DNA. Translation: EAW89394.1.
RefSeqiNP_001136073.1. NM_001142601.1.
NP_001136074.1. NM_001142602.1.
XP_005257823.1. XM_005257766.2.
UniGeneiHs.68061.

Genome annotation databases

GeneIDi8877.
KEGGihsa:8877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH012828
, AY278522, AY278523, AY278524 Genomic DNA. Translation: AAP35060.1.
AK292614 mRNA. Translation: BAF85303.1.
CH471099 Genomic DNA. Translation: EAW89388.1.
CH471099 Genomic DNA. Translation: EAW89389.1.
CH471099 Genomic DNA. Translation: EAW89390.1.
CH471099 Genomic DNA. Translation: EAW89391.1.
CH471099 Genomic DNA. Translation: EAW89394.1.
RefSeqiNP_001136073.1. NM_001142601.1.
NP_001136074.1. NM_001142602.1.
XP_005257823.1. XM_005257766.2.
UniGeneiHs.68061.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000313681.

Protocols and materials databases

DNASUi8877.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8877.
KEGGihsa:8877.

Organism-specific databases

CTDi8877.
PharmGKBiPA36070.

Phylogenomic databases

eggNOGiKOG1116. Eukaryota.
COG1597. LUCA.
HOVERGENiHBG054796.
KOiK04718.

Miscellaneous databases

ChiTaRSiSPHK1. human.
GenomeRNAii8877.

Gene expression databases

BgeeiENSG00000176170.

Family and domain databases

InterProiIPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53ZR5_HUMAN
AccessioniPrimary (citable) accession number: Q53ZR5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.