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Protein
Submitted name:

Bumetanide-sensitive Na-K-Cl cotransporter

Gene

SLC12A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Bumetanide-sensitive Na-K-Cl cotransporterImported
Submitted name:
Solute carrier family 12 (Sodium/potassium/chloride transporters), member 2, isoform CRA_bImported
Gene namesi
Name:SLC12A2Imported
ORF Names:hCG_27034Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei317 – 343HelicalSequence analysisAdd BLAST27
Transmembranei364 – 388HelicalSequence analysisAdd BLAST25
Transmembranei408 – 427HelicalSequence analysisAdd BLAST20
Transmembranei436 – 457HelicalSequence analysisAdd BLAST22
Transmembranei487 – 509HelicalSequence analysisAdd BLAST23
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Transmembranei602 – 622HelicalSequence analysisAdd BLAST21
Transmembranei655 – 675HelicalSequence analysisAdd BLAST21
Transmembranei681 – 699HelicalSequence analysisAdd BLAST19
Transmembranei711 – 730HelicalSequence analysisAdd BLAST20
Transmembranei736 – 751HelicalSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35806.

Expressioni

Gene expression databases

BgeeiENSG00000064651.
ExpressionAtlasiQ53ZR1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262461.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 255AA_permease_NInterPro annotationAdd BLAST54
Domaini290 – 792AA_permeaseInterPro annotationAdd BLAST503
Domaini801 – 1212SLC12InterPro annotationAdd BLAST412

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
HOVERGENiHBG052851.
KOiK10951.
OMAiLSMEYSK.
OrthoDBiEOG091G04G2.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR002443. Na/K/Cl_cotranspt.
IPR002444. NKCC1.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF58. PTHR11827:SF58. 3 hits.
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 1 hit.
[Graphical view]
PRINTSiPR01207. NAKCLTRNSPRT.
PR01208. NAKCLTRSPRT1.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53ZR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRPTAPSS GAPGLAGVGE TPSAAALAAA RVELPGTAVP SVPEDAAPAS
60 70 80 90 100
RDGGGVRDEG PAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA
110 120 130 140 150
AAAAAAAGAG AGAKQTPADG EASGESEPAK GSEEAKGRFR VNFVDPAASS
160 170 180 190 200
SAEDSLSDAA GVGVDGPNVS FQNGGDTVLS EGSSLHSGGG GGSGHHQHYY
210 220 230 240 250
YDTHTNTYYL RTFGHNTMDA VPRIDHYRHT AAQLGEKLLR PSLAELHDEL
260 270 280 290 300
EKEPFEDGFA NGEESTPTRD AVVTYTAESK GVVKFGWIKG VLVRCMLNIW
310 320 330 340 350
GVMLFIRLSW IVGQAGIGLS VLVIMMATVV TTITGLSTSA IATNGFVRGG
360 370 380 390 400
GAYYLISRSL GPEFGGAIGL IFAFANAVAV AMYVVGFAET VVELLKEHSI
410 420 430 440 450
LMIDEINDIR IIGAITVVIL LGISVAGMEW EAKAQIVLLV ILLLAIGDFV
460 470 480 490 500
IGTFIPLESK KPKGFFGYKS EIFNENFGPD FREEETFFSV FAIFFPAATG
510 520 530 540 550
ILAGANISGD LADPQSAIPK GTLLAILITT LVYVGIAVSV GSCVVRDATG
560 570 580 590 600
NVNDTIVTEL TNCTSAACKL NFDFSSCESS PCSYGLMNNF QVMSMVSGFT
610 620 630 640 650
PLISAGIFSA TLSSALASLV SAPKIFQALC KDNIYPAFQM FAKGYGKNNE
660 670 680 690 700
PLRGYILTFL IALGFILIAE LNVIAPIISN FFLASYALIN FSVFHASLAK
710 720 730 740 750
SPGWRPAFKY YNMWISLLGA ILCCIVMFVI NWWAALLTYV IVLGLYIYVT
760 770 780 790 800
YKKPDVNWGS STQALTYLNA LQHSIRLSGV EDHVKNFRPQ CLVMTGAPNS
810 820 830 840 850
RPALLHLVHD FTKNVGLMIC GHVHMGPRRQ AMKEMSIDQA KYQRWLIKNK
860 870 880 890 900
MKAFYAPVHA DDLREGAQYL MQAAGLGRMK PNTLVLGFKK DWLQADMRDV
910 920 930 940 950
DMYINLFHDA FDIQYGVVVI RLKEGLDISH LQGQEELLSS QEKSPGTKDV
960 970 980 990 1000
VVSVEYSKKS DLDTSKPLSE KPITHKVEEE DGKTATQPLL KKESKGPIVP
1010 1020 1030 1040 1050
LNVADQKLLE ASTQFQKKQG KNTIDVWWLF DDGGLTLLIP YLLTTKKKWK
1060 1070 1080 1090 1100
DCKIRVFIGG KINRIDHDRR AMATLLSKFR IDFSDIMVLG DINTKPKKEN
1110 1120 1130 1140 1150
IIAFEEIIEP YRLHEDDKEQ DIADKMKEDE PWRITDNELE LYKTKTYRQI
1160 1170 1180 1190 1200
RLNELLKEHS STANIIVMSL PVARKGAVSS ALYMAWLEAL SKDLPPILLV
1210
RGNHQSVLTF YS
Length:1,212
Mass (Da):131,447
Last modified:May 24, 2005 - v1
Checksum:iA6BF174ACCDA2EC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280459 mRNA. Translation: AAP33906.1.
CH471062 Genomic DNA. Translation: EAW62393.1.
CH471062 Genomic DNA. Translation: EAW62394.1.
RefSeqiNP_001037.1. NM_001046.2.
NP_001243390.1. NM_001256461.1.
UniGeneiHs.162585.
Hs.712970.

Genome annotation databases

GeneIDi6558.
KEGGihsa:6558.
UCSCiuc003kus.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280459 mRNA. Translation: AAP33906.1.
CH471062 Genomic DNA. Translation: EAW62393.1.
CH471062 Genomic DNA. Translation: EAW62394.1.
RefSeqiNP_001037.1. NM_001046.2.
NP_001243390.1. NM_001256461.1.
UniGeneiHs.162585.
Hs.712970.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6558.
KEGGihsa:6558.
UCSCiuc003kus.4. human.

Organism-specific databases

CTDi6558.
PharmGKBiPA35806.

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
HOVERGENiHBG052851.
KOiK10951.
OMAiLSMEYSK.
OrthoDBiEOG091G04G2.

Miscellaneous databases

ChiTaRSiSLC12A2. human.
GenomeRNAii6558.

Gene expression databases

BgeeiENSG00000064651.
ExpressionAtlasiQ53ZR1. baseline and differential.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR002443. Na/K/Cl_cotranspt.
IPR002444. NKCC1.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF58. PTHR11827:SF58. 3 hits.
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 1 hit.
[Graphical view]
PRINTSiPR01207. NAKCLTRNSPRT.
PR01208. NAKCLTRSPRT1.
TIGRFAMsiTIGR00930. 2a30. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ53ZR1_HUMAN
AccessioniPrimary (citable) accession number: Q53ZR1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.