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Q53Z09 (Q53Z09_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Potassium voltage-gated channel subfamily H member 2 Ensembl ENSMUSP00000047705
Gene names
Name:Kcnh2 MGI 1341722 Ensembl ENSMUSP00000047705
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1162 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains cyclic nucleotide-binding domain. SAAS SAAS000595

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS000595
   Molecular functionIon channel SAAS SAAS000595 RuleBase RU003378 EMBL AAQ82708.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

cellular response to drug

Inferred from electronic annotation. Source: Ensembl

membrane depolarization during action potential

Inferred from electronic annotation. Source: Ensembl

negative regulation of potassium ion export

Inferred from electronic annotation. Source: Ensembl

positive regulation of potassium ion transmembrane transport

Inferred from electronic annotation. Source: Ensembl

potassium ion export

Inferred from electronic annotation. Source: Ensembl

potassium ion homeostasis

Inferred from electronic annotation. Source: Ensembl

potassium ion transmembrane transport

Inferred from direct assay PubMed 9351446PubMed 9351462. Source: MGI

regulation of heart rate by cardiac conduction

Inferred from direct assay PubMed 10843886. Source: MGI

regulation of membrane potential

Inferred from direct assay PubMed 9351446PubMed 9351462. Source: MGI

regulation of ventricular cardiac muscle cell membrane repolarization

Inferred from direct assay PubMed 10843886. Source: MGI

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 14668215. Source: MGI

integral component of plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

nuclear envelope

Inferred from direct assay PubMed 14668215. Source: MGI

plasma membrane

Inferred from direct assay PubMed 14668215. Source: MGI

voltage-gated potassium channel complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiondelayed rectifier potassium channel activity

Inferred from electronic annotation. Source: Ensembl

inward rectifier potassium channel activity

Inferred from direct assay PubMed 9351462. Source: MGI

phosphorelay sensor kinase activity

Inferred from electronic annotation. Source: InterPro

voltage-gated potassium channel activity

Inferred from direct assay PubMed 9351446. Source: MGI

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q53Z09 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 47B49E6E71BDA58D

FASTA1,162126,905
        10         20         30         40         50         60 
MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE LCGYSRAEVM 

        70         80         90        100        110        120 
QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR KDGSCFLCLV DVVPVKNEDG 

       130        140        150        160        170        180 
AVIMFILNFE VVMEKDMVGS PAHDTNHRGP STSWLASGRA KTFRLKLPAL LALTARESSV 

       190        200        210        220        230        240 
RTGSMRSAGA PGAVVVDVDL TPAAPSSESL ALDEVSAMDN HVAGLGPAEE RRALVGPGSA 

       250        260        270        280        290        300 
SPVASIRGPH PSPRAQSLNP DASGSSCSLA RTRSRESCAS VRRASSADDI EAMRAGALPP 

       310        320        330        340        350        360 
PPRHASTGAM HPLRSGLLNS TSDSDLVRYR TISKIPQITL NFVDLKGDPF LASPTSDREI 

       370        380        390        400        410        420 
IAPKIKERTH NVTEKVTQVL SLGADVLPEY KLQAPRIHRW TILHYSPFKA VWDWLILLLV 

       430        440        450        460        470        480 
IYTAVFTPYS AAFLLKETED GSQAPDCGYA CQPLAVVDLI VDIMFIVDIL INFRTTYVNA 

       490        500        510        520        530        540 
NEEVVSHPGR IAVHYFKGWF LIDMVAAIPF DLLIFGSGSE ELIGLLKTAR LLRLVRVARK 

       550        560        570        580        590        600 
LDRYSEYGAA VLFLLMCTFA LIAHWLACIW YAIGNMEQPH MDSHIGWLHN LGDQIGKPYN 

       610        620        630        640        650        660 
SSGLGGPSIK DKYVTALYFT FSSLTSVGFG NVSPNTNSEK IFSICVMLIG SLMYASIFGN 

       670        680        690        700        710        720 
VSAIIQRLYS GTARYHTQML RVREFIRFHQ IPNPLRQRLE EYFQHAWSYT NGIDMNAVLK 

       730        740        750        760        770        780 
GFPECLQADI CLHLNRSLLQ HCKPFRGATK GCLRALAMKF KTTHAPPGDT LVHAGDLLTA 

       790        800        810        820        830        840 
LYFISRGSIE ILRGDVVVAI LGKNDIFGEP LNLYARPGKS NGDVRALTYC DLHKIHRDDL 

       850        860        870        880        890        900 
LEVLDMYPEF SDHFWSSLEI TFNLRDTNMI PGSPGSAELE SGFNRQRKRK LSFRRRTDKD 

       910        920        930        940        950        960 
TEQPGEVSAL GQGPARVGPG PSCRGQPGGP WGESPSSGPS SPESSEDEGP GRSSSPLRLV 

       970        980        990       1000       1010       1020 
PFSSPRPPGD PPGGEPLTED GEKSDTCNPL SGAFSGVSNI FSFWGDSRGR QYQELPRCPA 

      1030       1040       1050       1060       1070       1080 
PAPSLLNIPL SSPGRRSRGD VESRLDALQR QLNRLETRLS ADMATVLQLL QRQMTLVPPA 

      1090       1100       1110       1120       1130       1140 
YSAVTTPGPG PTSASPLLPV GPVPTLTLDS LSQVSQFVAF EELPAGAPEL PQDGPTRRLS 

      1150       1160 
LPGQLGALTS QPLHRHGSDP GS 

« Hide

References

« Hide 'large scale' references
[1]"Erg type potassium channel in mouse inner ears."
Nie L., Mu K., Feng W., Vazquaz A.E., Yamoah E.N.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL EMBL AAQ82708.1.
Tissue: Cochlea EMBL AAQ82708.1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000047705.
[3]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000047705.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC113055 Genomic DNA. No translation available.
AY374424 mRNA. Translation: AAQ82708.1.
RefSeqNP_038597.2. NM_013569.2.
UniGeneMm.6539.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036092; ENSMUSP00000047705; ENSMUSG00000038319.
GeneID16511.
KEGGmmu:16511.
UCSCuc008wrc.1. mouse.

Organism-specific databases

CTD3757.
MGIMGI:1341722. Kcnh2.

Phylogenomic databases

GeneTreeENSGT00680000099663.
HOVERGENHBG052232.
InParanoidQ53Z09.
KOK04905.
OMAPARDTNH.
OrthoDBEOG75B879.
TreeFamTF313130.

Gene expression databases

GenevestigatorQ53Z09.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289853.
SOURCESearch...

Entry information

Entry nameQ53Z09_MOUSE
AccessionPrimary (citable) accession number: Q53Z09
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)