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Protein
Submitted name:

Potassium channel erg1a

Gene

Kcnh2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: MGI
  2. identical protein binding Source: MGI
  3. inward rectifier potassium channel activity Source: MGI
  4. phosphorelay sensor kinase activity Source: InterPro
  5. protein homodimerization activity Source: MGI
  6. scaffold protein binding Source: MGI
  7. ubiquitin protein ligase binding Source: MGI
  8. voltage-gated potassium channel activity Source: MGI
  9. voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Source: MGI

GO - Biological processi

  1. cardiac muscle contraction Source: MGI
  2. cellular response to drug Source: MGI
  3. membrane depolarization during action potential Source: MGI
  4. membrane repolarization during action potential Source: MGI
  5. membrane repolarization during cardiac muscle cell action potential Source: MGI
  6. negative regulation of potassium ion export Source: MGI
  7. negative regulation of potassium ion transmembrane transport Source: MGI
  8. positive regulation of potassium ion transmembrane transport Source: MGI
  9. potassium ion export Source: MGI
  10. potassium ion homeostasis Source: MGI
  11. potassium ion transmembrane transport Source: MGI
  12. regulation of heart rate by cardiac conduction Source: MGI
  13. regulation of membrane potential Source: MGI
  14. regulation of membrane repolarization Source: MGI
  15. regulation of potassium ion transmembrane transport Source: MGI
  16. regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
  17. ventricular cardiac muscle cell action potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel erg1aImported
Submitted name:
Potassium voltage-gated channel subfamily H member 2Imported
Gene namesi
Name:Kcnh2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1341722. Kcnh2.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. cytoplasm Source: MGI
  3. integral component of plasma membrane Source: GO_Central
  4. nuclear envelope Source: MGI
  5. plasma membrane Source: MGI
  6. voltage-gated potassium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ53Z09.

Family & Domainsi

Sequence similaritiesi

Contains cyclic nucleotide-binding domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118772.
HOVERGENiHBG052232.
KOiK04905.
OMAiGSDTCNP.
OrthoDBiEOG75B879.
TreeFamiTF313130.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR030172. KCNH2.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10217:SF468. PTHR10217:SF468. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53Z09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE
60 70 80 90 100
LCGYSRAEVM QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR
110 120 130 140 150
KDGSCFLCLV DVVPVKNEDG AVIMFILNFE VVMEKDMVGS PAHDTNHRGP
160 170 180 190 200
STSWLASGRA KTFRLKLPAL LALTARESSV RTGSMRSAGA PGAVVVDVDL
210 220 230 240 250
TPAAPSSESL ALDEVSAMDN HVAGLGPAEE RRALVGPGSA SPVASIRGPH
260 270 280 290 300
PSPRAQSLNP DASGSSCSLA RTRSRESCAS VRRASSADDI EAMRAGALPP
310 320 330 340 350
PPRHASTGAM HPLRSGLLNS TSDSDLVRYR TISKIPQITL NFVDLKGDPF
360 370 380 390 400
LASPTSDREI IAPKIKERTH NVTEKVTQVL SLGADVLPEY KLQAPRIHRW
410 420 430 440 450
TILHYSPFKA VWDWLILLLV IYTAVFTPYS AAFLLKETED GSQAPDCGYA
460 470 480 490 500
CQPLAVVDLI VDIMFIVDIL INFRTTYVNA NEEVVSHPGR IAVHYFKGWF
510 520 530 540 550
LIDMVAAIPF DLLIFGSGSE ELIGLLKTAR LLRLVRVARK LDRYSEYGAA
560 570 580 590 600
VLFLLMCTFA LIAHWLACIW YAIGNMEQPH MDSHIGWLHN LGDQIGKPYN
610 620 630 640 650
SSGLGGPSIK DKYVTALYFT FSSLTSVGFG NVSPNTNSEK IFSICVMLIG
660 670 680 690 700
SLMYASIFGN VSAIIQRLYS GTARYHTQML RVREFIRFHQ IPNPLRQRLE
710 720 730 740 750
EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLNRSLLQ HCKPFRGATK
760 770 780 790 800
GCLRALAMKF KTTHAPPGDT LVHAGDLLTA LYFISRGSIE ILRGDVVVAI
810 820 830 840 850
LGKNDIFGEP LNLYARPGKS NGDVRALTYC DLHKIHRDDL LEVLDMYPEF
860 870 880 890 900
SDHFWSSLEI TFNLRDTNMI PGSPGSAELE SGFNRQRKRK LSFRRRTDKD
910 920 930 940 950
TEQPGEVSAL GQGPARVGPG PSCRGQPGGP WGESPSSGPS SPESSEDEGP
960 970 980 990 1000
GRSSSPLRLV PFSSPRPPGD PPGGEPLTED GEKSDTCNPL SGAFSGVSNI
1010 1020 1030 1040 1050
FSFWGDSRGR QYQELPRCPA PAPSLLNIPL SSPGRRSRGD VESRLDALQR
1060 1070 1080 1090 1100
QLNRLETRLS ADMATVLQLL QRQMTLVPPA YSAVTTPGPG PTSASPLLPV
1110 1120 1130 1140 1150
GPVPTLTLDS LSQVSQFVAF EELPAGAPEL PQDGPTRRLS LPGQLGALTS
1160
QPLHRHGSDP GS
Length:1,162
Mass (Da):126,905
Last modified:May 24, 2005 - v1
Checksum:i47B49E6E71BDA58D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113055 Genomic DNA. No translation available.
AY374424 mRNA. Translation: AAQ82708.1.
RefSeqiNP_038597.2. NM_013569.2.
UniGeneiMm.6539.

Genome annotation databases

EnsembliENSMUST00000036092; ENSMUSP00000047705; ENSMUSG00000038319.
GeneIDi16511.
KEGGimmu:16511.
UCSCiuc008wrc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113055 Genomic DNA. No translation available.
AY374424 mRNA. Translation: AAQ82708.1.
RefSeqiNP_038597.2. NM_013569.2.
UniGeneiMm.6539.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036092; ENSMUSP00000047705; ENSMUSG00000038319.
GeneIDi16511.
KEGGimmu:16511.
UCSCiuc008wrc.1. mouse.

Organism-specific databases

CTDi3757.
MGIiMGI:1341722. Kcnh2.

Phylogenomic databases

GeneTreeiENSGT00760000118772.
HOVERGENiHBG052232.
KOiK04905.
OMAiGSDTCNP.
OrthoDBiEOG75B879.
TreeFamiTF313130.

Miscellaneous databases

NextBioi289853.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ53Z09.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR030172. KCNH2.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10217:SF468. PTHR10217:SF468. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Erg type potassium channel in mouse inner ears."
    Nie L., Mu K., Feng W., Vazquaz A.E., Yamoah E.N.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BLImported.
    Tissue: CochleaImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ53Z09_MOUSE
AccessioniPrimary (citable) accession number: Q53Z09
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 29, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.