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Q53Z09

- Q53Z09_MOUSE

UniProt

Q53Z09 - Q53Z09_MOUSE

Protein
Submitted name:

Potassium channel erg1a

Gene

Kcnh2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: Ensembl
    2. inward rectifier potassium channel activity Source: MGI
    3. phosphorelay sensor kinase activity Source: InterPro
    4. voltage-gated potassium channel activity Source: MGI
    5. voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Source: Ensembl

    GO - Biological processi

    1. cardiac muscle contraction Source: Ensembl
    2. cellular response to drug Source: Ensembl
    3. membrane depolarization during action potential Source: Ensembl
    4. negative regulation of potassium ion export Source: Ensembl
    5. positive regulation of potassium ion transmembrane transport Source: Ensembl
    6. potassium ion export Source: Ensembl
    7. potassium ion homeostasis Source: Ensembl
    8. potassium ion transmembrane transport Source: MGI
    9. regulation of heart rate by cardiac conduction Source: MGI
    10. regulation of membrane potential Source: MGI
    11. regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI

    Keywords - Molecular functioni

    Ion channelUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Potassium channel erg1aImported
    Submitted name:
    Potassium voltage-gated channel subfamily H member 2Imported
    Gene namesi
    Name:Kcnh2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1341722. Kcnh2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: MGI
    3. integral component of plasma membrane Source: RefGenome
    4. nuclear envelope Source: MGI
    5. plasma membrane Source: MGI
    6. voltage-gated potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ53Z09.

    Family & Domainsi

    Sequence similaritiesi

    Contains cyclic nucleotide-binding domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00680000099663.
    HOVERGENiHBG052232.
    InParanoidiQ53Z09.
    KOiK04905.
    OMAiPARDTNH.
    OrthoDBiEOG75B879.
    TreeFamiTF313130.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003967. K_chnl_volt-dep_ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01470. ERGCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q53Z09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE     50
    LCGYSRAEVM QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR 100
    KDGSCFLCLV DVVPVKNEDG AVIMFILNFE VVMEKDMVGS PAHDTNHRGP 150
    STSWLASGRA KTFRLKLPAL LALTARESSV RTGSMRSAGA PGAVVVDVDL 200
    TPAAPSSESL ALDEVSAMDN HVAGLGPAEE RRALVGPGSA SPVASIRGPH 250
    PSPRAQSLNP DASGSSCSLA RTRSRESCAS VRRASSADDI EAMRAGALPP 300
    PPRHASTGAM HPLRSGLLNS TSDSDLVRYR TISKIPQITL NFVDLKGDPF 350
    LASPTSDREI IAPKIKERTH NVTEKVTQVL SLGADVLPEY KLQAPRIHRW 400
    TILHYSPFKA VWDWLILLLV IYTAVFTPYS AAFLLKETED GSQAPDCGYA 450
    CQPLAVVDLI VDIMFIVDIL INFRTTYVNA NEEVVSHPGR IAVHYFKGWF 500
    LIDMVAAIPF DLLIFGSGSE ELIGLLKTAR LLRLVRVARK LDRYSEYGAA 550
    VLFLLMCTFA LIAHWLACIW YAIGNMEQPH MDSHIGWLHN LGDQIGKPYN 600
    SSGLGGPSIK DKYVTALYFT FSSLTSVGFG NVSPNTNSEK IFSICVMLIG 650
    SLMYASIFGN VSAIIQRLYS GTARYHTQML RVREFIRFHQ IPNPLRQRLE 700
    EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLNRSLLQ HCKPFRGATK 750
    GCLRALAMKF KTTHAPPGDT LVHAGDLLTA LYFISRGSIE ILRGDVVVAI 800
    LGKNDIFGEP LNLYARPGKS NGDVRALTYC DLHKIHRDDL LEVLDMYPEF 850
    SDHFWSSLEI TFNLRDTNMI PGSPGSAELE SGFNRQRKRK LSFRRRTDKD 900
    TEQPGEVSAL GQGPARVGPG PSCRGQPGGP WGESPSSGPS SPESSEDEGP 950
    GRSSSPLRLV PFSSPRPPGD PPGGEPLTED GEKSDTCNPL SGAFSGVSNI 1000
    FSFWGDSRGR QYQELPRCPA PAPSLLNIPL SSPGRRSRGD VESRLDALQR 1050
    QLNRLETRLS ADMATVLQLL QRQMTLVPPA YSAVTTPGPG PTSASPLLPV 1100
    GPVPTLTLDS LSQVSQFVAF EELPAGAPEL PQDGPTRRLS LPGQLGALTS 1150
    QPLHRHGSDP GS 1162
    Length:1,162
    Mass (Da):126,905
    Last modified:May 24, 2005 - v1
    Checksum:i47B49E6E71BDA58D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113055 Genomic DNA. No translation available.
    AY374424 mRNA. Translation: AAQ82708.1.
    RefSeqiNP_038597.2. NM_013569.2.
    UniGeneiMm.6539.

    Genome annotation databases

    EnsembliENSMUST00000036092; ENSMUSP00000047705; ENSMUSG00000038319.
    GeneIDi16511.
    KEGGimmu:16511.
    UCSCiuc008wrc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113055 Genomic DNA. No translation available.
    AY374424 mRNA. Translation: AAQ82708.1 .
    RefSeqi NP_038597.2. NM_013569.2.
    UniGenei Mm.6539.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036092 ; ENSMUSP00000047705 ; ENSMUSG00000038319 .
    GeneIDi 16511.
    KEGGi mmu:16511.
    UCSCi uc008wrc.1. mouse.

    Organism-specific databases

    CTDi 3757.
    MGIi MGI:1341722. Kcnh2.

    Phylogenomic databases

    GeneTreei ENSGT00680000099663.
    HOVERGENi HBG052232.
    InParanoidi Q53Z09.
    KOi K04905.
    OMAi PARDTNH.
    OrthoDBi EOG75B879.
    TreeFami TF313130.

    Miscellaneous databases

    NextBioi 289853.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q53Z09.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003967. K_chnl_volt-dep_ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01470. ERGCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Erg type potassium channel in mouse inner ears."
      Nie L., Mu K., Feng W., Vazquaz A.E., Yamoah E.N.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BLImported.
      Tissue: CochleaImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ53Z09_MOUSE
    AccessioniPrimary (citable) accession number: Q53Z09
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3