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Protein
Submitted name:

ATP-sensitive inward rectifier potassium channel 15

Gene

Kcnj15

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei157 – 1571Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transportUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-sensitive inward rectifier potassium channel 15Imported
Submitted name:
Inward rectifying potassium channel Kir4.2Imported
Submitted name:
Kcnj15 proteinImported
Submitted name:
Potassium inwardly rectifying channelImported
Submitted name:
Potassium inwardly-rectifying channel, subfamily J, member 15, isoform CRA_aImported
Gene namesi
Name:Kcnj15Imported
Synonyms:Kir4.2Imported
ORF Names:mCG_2220Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1310000. Kcnj15.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei67 – 8822HelicalSequence analysisAdd
BLAST
Transmembranei142 – 16625HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045218.

Family & Domainsi

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOVERGENiHBG006178.
KOiK05008.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53Z04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIHLGMSS APLVKHTNGV GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY
60 70 80 90 100
LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVVYYAIAF IHGDLQLGES
110 120 130 140 150
NSNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL
160 170 180 190 200
VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVISKQN GKLCLVIQVA
210 220 230 240 250
NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL
260 270 280 290 300
PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
310 320 330 340 350
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQK
360 370
LEEQYRQEDQ RERELRSLLL QQSNV
Length:375
Mass (Da):42,605
Last modified:May 24, 2005 - v1
Checksum:i163277597D4B2C8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154546 Genomic DNA. No translation available.
AC154691 Genomic DNA. No translation available.
BC138478 mRNA. Translation: AAI38479.1.
AY377988 mRNA. Translation: AAQ88166.1.
AK165436 mRNA. Translation: BAE38186.1.
AJ300831 mRNA. Translation: CAC83656.1.
CH466602 Genomic DNA. Translation: EDL03715.1.
CH466602 Genomic DNA. Translation: EDL03716.1.
RefSeqiNP_001034145.1. NM_001039056.2.
NP_001034146.1. NM_001039057.2.
NP_001258616.1. NM_001271687.1.
NP_001258618.1. NM_001271689.1.
NP_001258619.1. NM_001271690.1.
NP_001258620.1. NM_001271691.1.
NP_001258622.1. NM_001271693.1.
NP_001258623.1. NM_001271694.1.
NP_001258624.1. NM_001271695.1.
NP_062638.1. NM_019664.5.
XP_006523014.1. XM_006522951.2.
XP_006523015.1. XM_006522952.2.
XP_006523249.1. XM_006523186.2.
XP_006523250.1. XM_006523187.2.
XP_006523251.1. XM_006523188.2.
XP_006523252.1. XM_006523189.2.
XP_006523253.1. XM_006523190.2.
XP_006523254.1. XM_006523191.2.
XP_006523255.1. XM_006523192.2.
XP_006523256.1. XM_006523193.2.
UniGeneiMm.272239.
Mm.491313.

Genome annotation databases

EnsembliENSMUST00000113854; ENSMUSP00000109485; ENSMUSG00000062609.
ENSMUST00000113855; ENSMUSP00000109486; ENSMUSG00000062609.
ENSMUST00000113856; ENSMUSP00000109487; ENSMUSG00000062609.
GeneIDi16516.
KEGGimmu:16516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154546 Genomic DNA. No translation available.
AC154691 Genomic DNA. No translation available.
BC138478 mRNA. Translation: AAI38479.1.
AY377988 mRNA. Translation: AAQ88166.1.
AK165436 mRNA. Translation: BAE38186.1.
AJ300831 mRNA. Translation: CAC83656.1.
CH466602 Genomic DNA. Translation: EDL03715.1.
CH466602 Genomic DNA. Translation: EDL03716.1.
RefSeqiNP_001034145.1. NM_001039056.2.
NP_001034146.1. NM_001039057.2.
NP_001258616.1. NM_001271687.1.
NP_001258618.1. NM_001271689.1.
NP_001258619.1. NM_001271690.1.
NP_001258620.1. NM_001271691.1.
NP_001258622.1. NM_001271693.1.
NP_001258623.1. NM_001271694.1.
NP_001258624.1. NM_001271695.1.
NP_062638.1. NM_019664.5.
XP_006523014.1. XM_006522951.2.
XP_006523015.1. XM_006522952.2.
XP_006523249.1. XM_006523186.2.
XP_006523250.1. XM_006523187.2.
XP_006523251.1. XM_006523188.2.
XP_006523252.1. XM_006523189.2.
XP_006523253.1. XM_006523190.2.
XP_006523254.1. XM_006523191.2.
XP_006523255.1. XM_006523192.2.
XP_006523256.1. XM_006523193.2.
UniGeneiMm.272239.
Mm.491313.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045218.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113854; ENSMUSP00000109485; ENSMUSG00000062609.
ENSMUST00000113855; ENSMUSP00000109486; ENSMUSG00000062609.
ENSMUST00000113856; ENSMUSP00000109487; ENSMUSG00000062609.
GeneIDi16516.
KEGGimmu:16516.

Organism-specific databases

CTDi3772.
MGIiMGI:1310000. Kcnj15.

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOVERGENiHBG006178.
KOiK05008.

Miscellaneous databases

ChiTaRSiKcnj15. mouse.
NextBioi289873.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  4. "Developmentally regulated expression of the murine ortholog of the potassium channel KIR4.2 (KCNJ15)."
    Thiery E., Gosset P., Damotte D., Delezoide A.-L., de Saint-Sauveur N., Vayssettes C., Creau N.
    Mech. Dev. 95:313-316(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  6. "Comparative organisation of the mouse and human kir4.2 genes."
    Thiery E., Berthuy I., Gosset P., Creau N.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  8. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  9. "Interaction of inner ear-specific Kir channels."
    Nie L., Feng W.H., Vazquez A.E., Yamoah E.N.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BLImported.
    Tissue: CochleaImported.
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  12. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  13. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  14. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  16. Ensembl
    Submitted (AUG-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ53Z04_MOUSE
AccessioniPrimary (citable) accession number: Q53Z04
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.