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Protein
Submitted name:

Angiotensin II receptor, type 1

Gene

AGTR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Angiotensin II receptor, type 1Imported
Submitted name:
Angiotensin II receptor, type 1, isoform CRA_bImported
Submitted name:
cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNAImported
Gene namesi
Name:AGTR1Imported
ORF Names:hCG_2022206Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 56HelicalSequence analysisAdd BLAST23
Transmembranei68 – 90HelicalSequence analysisAdd BLAST23
Transmembranei110 – 131HelicalSequence analysisAdd BLAST22
Transmembranei143 – 165HelicalSequence analysisAdd BLAST23
Transmembranei201 – 218HelicalSequence analysisAdd BLAST18
Transmembranei238 – 262HelicalSequence analysisAdd BLAST25
Transmembranei282 – 305HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA43.

Expressioni

Gene expression databases

BgeeiENSG00000144891.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273430.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 302G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST258

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG104998.
KOiK04166.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53YY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF
260 270 280 290 300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK

KPAPCFEVE
Length:359
Mass (Da):41,061
Last modified:May 24, 2005 - v1
Checksum:i35FC856F53E911A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436325 Genomic DNA. Translation: AAR03503.1.
EU332837 Genomic DNA. Translation: ABY87526.1.
AK291541 mRNA. Translation: BAF84230.1.
CH471052 Genomic DNA. Translation: EAW78906.1.
CH471052 Genomic DNA. Translation: EAW78907.1.
RefSeqiNP_000676.1. NM_000685.4.
NP_033611.1. NM_009585.3.
UniGeneiHs.477887.
Hs.744837.

Genome annotation databases

GeneIDi185.
KEGGihsa:185.
UCSCiuc003ewi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436325 Genomic DNA. Translation: AAR03503.1.
EU332837 Genomic DNA. Translation: ABY87526.1.
AK291541 mRNA. Translation: BAF84230.1.
CH471052 Genomic DNA. Translation: EAW78906.1.
CH471052 Genomic DNA. Translation: EAW78907.1.
RefSeqiNP_000676.1. NM_000685.4.
NP_033611.1. NM_009585.3.
UniGeneiHs.477887.
Hs.744837.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000273430.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

DNASUi185.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi185.
KEGGihsa:185.
UCSCiuc003ewi.3. human.

Organism-specific databases

CTDi185.
PharmGKBiPA43.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG104998.
KOiK04166.

Miscellaneous databases

GenomeRNAii185.

Gene expression databases

BgeeiENSG00000144891.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53YY0_HUMAN
AccessioniPrimary (citable) accession number: Q53YY0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.