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Protein
Submitted name:

MHC class I antigen

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-CImported
Synonyms:HLA-CwImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei306 – 331HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501509775225 – 366Sequence analysisAdd BLAST342

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q53YP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV
110 120 130 140 150
SLRNLRGYYN QSEAGSHIIQ RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRYLKNGK
210 220 230 240 250
ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS
360
SNSAQGSDES LIACKA
Length:366
Mass (Da):40,861
Last modified:May 24, 2005 - v1
Checksum:i47E55680EA1F6D97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY530953 Genomic DNA Translation: AAS98883.1
FJ515903 Genomic DNA Translation: ACL37147.1
FJ827034 Genomic DNA Translation: ACO58590.1
HM543699 Genomic DNA Translation: ADU18051.1
KU319225 Genomic DNA Translation: ANG08641.1
KU319226 Genomic DNA Translation: ANG08642.1
KU319227 Genomic DNA Translation: ANG08643.1
KX622677 Genomic DNA Translation: AOV81314.1
KX523606 Genomic DNA Translation: ARE89964.1
KX686518 Genomic DNA Translation: ARX98026.1
KY419384 Genomic DNA Translation: ASU50275.1
KY419385 Genomic DNA Translation: ASU50276.1
KY419386 Genomic DNA Translation: ASU50277.1
KY419387 Genomic DNA Translation: ASU50278.1
MF582480 Genomic DNA Translation: ATG80407.1
MF927949 Genomic DNA Translation: ATN38486.1
MG944947 Genomic DNA Translation: AVV63097.1
FN908176 Genomic DNA Translation: CBM42647.1
LN811501 Genomic DNA Translation: CEP25328.1
LN912839 Genomic DNA Translation: CUU97166.1
LN912876 Genomic DNA Translation: CUU97203.1
LT599321 Genomic DNA Translation: SBW38542.1
LT599341 Genomic DNA Translation: SBW38562.1
LT599349 Genomic DNA Translation: SBW38570.1
LT599407 Genomic DNA Translation: SBW38628.1
LT618797 Genomic DNA Translation: SCQ83613.1
LT964783 Genomic DNA Translation: SOT92887.2
LT964816 Genomic DNA Translation: SOT92920.2
LT966212 Genomic DNA Translation: SOU90366.1
LT966372 Genomic DNA Translation: SOU94009.1
LT966397 Genomic DNA Translation: SOU94034.1
UniGeneiHs.656020
Hs.743218

Genome annotation databases

UCSCiuc011hpd.3 human

Similar proteinsi

Entry informationi

Entry nameiQ53YP1_HUMAN
AccessioniPrimary (citable) accession number: Q53YP1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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