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Protein

Amine oxidase [flavin-containing]

Gene

MAOA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.UniRule annotation

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.UniRule annotation

Cofactori

FADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing]UniRule annotation (EC:1.4.3.4UniRule annotation)
Alternative name(s):
Monoamine oxidaseUniRule annotation
Gene namesi
Name:MAOAImported
ORF Names:hCG_16826Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Mitochondrion outer membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA236.

PTM / Processingi

Keywords - PTMi

AcetylationUniRule annotation

Proteomic databases

MaxQBiQ53YE7.

Expressioni

Gene expression databases

BgeeiENSG00000189221.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000340684.

Structurei

3D structure databases

SMRiQ53YE7. Positions 12-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 460438Amino_oxidaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
HOVERGENiHBG004255.
KOiK00274.
OMAiDAPWEAP.
OrthoDBiEOG091G0G7P.
PhylomeDBiQ53YE7.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q53YE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQEKASIA GHMFDVVVIG GGISGLSAAK LLTEYGVSVL VLEARDRVGG
60 70 80 90 100
RTYTIRNEHV DYVDVGGAYV GPTQNRILRL SKELGIETYK VNVSERLVQY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT IDNMGKEIPT DAPWEAQHAD
160 170 180 190 200
KWDKMTMKEL IDKICWTKTA RRFAYLFVNI NVTSEPHEVS ALWFLWYVKQ
210 220 230 240 250
CGGTTRIFSV TNGGQERKFV GGSGQVSERI MDLLGDQVKL NHPVTHVDQS
260 270 280 290 300
SDNIIIETLN HEHYECKYVI NAIPPTLTAK IHFRPELPAE RNQLIQRLPM
310 320 330 340 350
GAVIKCMMYY KEAFWKKKDY CGCMIIEDED APISITLDDT KPDGSLPAIM
360 370 380 390 400
GFILARKADR LAKLHKEIRK KKICELYAKV LGSQEALHPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI FFAGTETATK WSGYMEGAVE
460 470 480 490 500
AGERAAREVL NGLGKVTEKD IWVQEPESKD VPAVEITHTF WERNLPSVSG
510 520
LLKIIGFSTS VTALGFVLYK YKLLPRS
Length:527
Mass (Da):59,682
Last modified:February 5, 2008 - v1
Checksum:i4270E346928AE832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT006651 mRNA. Translation: AAP35297.1.
AK291769 mRNA. Translation: BAF84458.1.
CH471141 Genomic DNA. Translation: EAW59381.1.
CH471141 Genomic DNA. Translation: EAW59383.1.
RefSeqiNP_000231.1. NM_000240.3.
UniGeneiHs.183109.

Genome annotation databases

GeneIDi4128.
KEGGihsa:4128.
UCSCiuc004dfy.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT006651 mRNA. Translation: AAP35297.1.
AK291769 mRNA. Translation: BAF84458.1.
CH471141 Genomic DNA. Translation: EAW59381.1.
CH471141 Genomic DNA. Translation: EAW59383.1.
RefSeqiNP_000231.1. NM_000240.3.
UniGeneiHs.183109.

3D structure databases

SMRiQ53YE7. Positions 12-524.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340684.

Proteomic databases

MaxQBiQ53YE7.

Protocols and materials databases

DNASUi4128.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4128.
KEGGihsa:4128.
UCSCiuc004dfy.5. human.

Organism-specific databases

CTDi4128.
PharmGKBiPA236.

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
HOVERGENiHBG004255.
KOiK00274.
OMAiDAPWEAP.
OrthoDBiEOG091G0G7P.
PhylomeDBiQ53YE7.

Miscellaneous databases

ChiTaRSiMAOA. human.
GenomeRNAii4128.

Gene expression databases

BgeeiENSG00000189221.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ53YE7_HUMAN
AccessioniPrimary (citable) accession number: Q53YE7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.