Q53YC7 (Q53YC7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Pre-B-cell leukemia transcription factor 1 EMBL AAP35351.1

Submitted name:
Pre-B-cell leukemia transcription factor 1, isoform CRA_c EMBL EAW90741.1

Gene names

Name:	PBX1 EMBL EAW90741.1
ORF Names:	hCG_23011 EMBL EAW90741.1

Organism

Homo sapiens (Human) EMBL AAP35351.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity RuleBase RU000682.

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682
Domain	Homeobox RuleBase RU000682
Ligand	DNA-binding RuleBase RU000682
Gene Ontology (GO)
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q53YC7 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: C4A2BDDD4A410C20	FASTA	347	38,427
	10 20 30 40 50 60 MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE 70 80 90 100 110 120 AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP 130 140 150 160 170 180 EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM 190 200 210 220 230 240 NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF 250 260 270 280 290 300 NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE 310 320 330 340 EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGGYPSPCY QPDRRIQ

References

[1]	"Cloning of human full-length CDSs in BD Creator(TM) System Donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT006705 mRNA. Translation: AAP35351.1. CH471067 Genomic DNA. Translation: EAW90741.1.
IPI	IPI00215683.
RefSeq	NP_001191890.1. NM_001204961.1.
UniGene	Hs.557097.
3D structure databases
SMR	Q53YC7. Positions 233-305.
ModBase	Search...
Proteomic databases
PRIDE	Q53YC7.
Protocols and materials databases
DNASU	5087.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5087.
KEGG	hsa:5087.
UCSC	uc001gcs.3. human.
Organism-specific databases
CTD	5087.
Phylogenomic databases
HOGENOM	HOG000266972.
HOVERGEN	HBG000122.
KO	K09355.
Gene expression databases
ArrayExpress	Q53YC7.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR005542. PBX. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF03792. PBC. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PBX1. human.
GenomeRNAi	5087.
NextBio	19618.

Entry information

Entry name

Q53YC7_HUMAN

Accession

Primary (citable) accession number: Q53YC7

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.