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Protein
Submitted name:

Thymidylate synthetase

Gene

TYMS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei195PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Thymidylate synthetaseImported
Submitted name:
Thymidylate synthetase, isoform CRA_fImported
Submitted name:
cDNA, FLJ94841, Homo sapiens thymidylate synthetase (TYMS), mRNAImported
Gene namesi
Name:TYMSImported
ORF Names:hCG_1994842Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000176890.15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA359

PTM / Processingi

Proteomic databases

MaxQBiQ53Y97

Expressioni

Gene expression databases

BgeeiENSG00000176890
ExpressionAtlasiQ53Y97 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ53Y97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 313Thymidylat_syntInterPro annotationAdd BLAST282

Phylogenomic databases

eggNOGiKOG0673 Eukaryota
COG0207 LUCA
HOVERGENiHBG001934
KOiK00560
OMAiKQYLDLC
OrthoDBiEOG091G0CV0

Family and domain databases

CDDicd00351 TS_Pyrimidine_HMase, 1 hit
Gene3Di3.30.572.10, 1 hit
HAMAPiMF_00008 Thymidy_synth_bact, 1 hit
InterProiView protein in InterPro
IPR023451 Thymidate_synth/dCMP_Mease
IPR036926 Thymidate_synth/dCMP_Mease_sf
IPR000398 Thymidylate_synthase
IPR020940 Thymidylate_synthase_AS
PfamiView protein in Pfam
PF00303 Thymidylat_synt, 1 hit
PRINTSiPR00108 THYMDSNTHASE
SUPFAMiSSF55831 SSF55831, 1 hit
TIGRFAMsiTIGR03284 thym_sym, 1 hit
PROSITEiView protein in PROSITE
PS00091 THYMIDYLATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q53Y97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR
60 70 80 90 100
TGTGTLSVFG MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE
110 120 130 140 150
LSSKGVKIWD ANGSRDFLDS LGFSTREEGD LGPVYGFQWR HFGAEYRDME
160 170 180 190 200
SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC AWNPRDLPLM ALPPCHALCQ
210 220 230 240 250
FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI TGLKPGDFIH
260 270 280 290 300
TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG
310
YNPHPTIKME MAV
Length:313
Mass (Da):35,716
Last modified:May 24, 2005 - v1
Checksum:i148D377F19915B6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT006811 mRNA Translation: AAP35457.1
AK314140 mRNA Translation: BAG36830.1
CH471113 Genomic DNA Translation: EAX01721.1
RefSeqiNP_001062.1, NM_001071.2
UniGeneiHs.369762

Genome annotation databases

GeneIDi7298
KEGGihsa:7298
UCSCiuc010dka.2 human

Similar proteinsi

Entry informationi

Entry nameiQ53Y97_HUMAN
AccessioniPrimary (citable) accession number: Q53Y97
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health