Q53Y83 (Q53Y83_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Galactosidase, alpha EMBL AAP35510.1

Submitted name:
Galactosidase, alpha, isoform CRA_a EMBL EAX02862.1
Submitted name:
cDNA FLJ76285, highly similar to Homo sapiens galactosidase, alpha (GLA), mRNA EMBL BAF83784.1

Gene names

Name:	GLA EMBL EAX02862.1
ORF Names:	hCG_20401 EMBL EAX02862.1

Organism

Homo sapiens (Human) EMBL AAP35510.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Glycosidase SAAS SAAS000111 Hydrolase
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycosylceramide catabolic process Inferred from electronic annotation. Source: Compara negative regulation of nitric oxide biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of nitric-oxide synthase activity Inferred from electronic annotation. Source: Compara
Cellular_component	lysosome Inferred from electronic annotation. Source: Compara
Molecular_function	alpha-galactosidase activity Inferred from electronic annotation. Source: Compara galactoside binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q53Y83 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 613F8BF21B107D7B	FASTA	429	48,767
	10 20 30 40 50 60 MQLRNPELHL GCALALRFLA LVSWDIPGAR ALDNGLARTP TMGWLHWERF MCNLDCQEEP 70 80 90 100 110 120 DSCISEKLFM EMAELMVSEG WKDAGYEYLC IDDCWMAPQR DSEGRLQADP QRFPHGIRQL 130 140 150 160 170 180 ANYVHSKGLK LGIYADVGNK TCAGFPGSFG YYDIDAQTFA DWGVDLLKFD GCYCDSLENL 190 200 210 220 230 240 ADGYKHMSLA LNRTGRSIVY SCEWPLYMWP FQKPNYTEIR QYCNHWRNFA DIDDSWKSIK 250 260 270 280 290 300 SILDWTSFNQ ERIVDVAGPG GWNDPDMLVI GNFGLSWNQQ VTQMALWAIM AAPLFMSNDL 310 320 330 340 350 360 RHISPQAKAL LQDKDVIAIN QDPLGKQGYQ LRQGDNFEVW ERPLSGLAWA VAMINRQEIG 370 380 390 400 410 420 GPRSYTIAVA SLGKGVACNP ACFITQLLPV KRKLGFYEWT SRLRSHINPT GTVLLQLENT MQMSLKDLL

References

[1]	"Cloning of human full-length CDSs in BD Creator(TM) System Donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO human cDNA sequencing project." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT006864 mRNA. Translation: AAP35510.1. AK291095 mRNA. Translation: BAF83784.1. CH471115 Genomic DNA. Translation: EAX02862.1.
IPI	IPI00025869.
RefSeq	NP_000160.1. NM_000169.2.
UniGene	Hs.69089.
3D structure databases
ProteinModelPortal	Q53Y83.
ModBase	Search...
Protein-protein interaction databases
STRING	Q53Y83.
Protein family/group databases
Allergome	9621. Hom s alpha-Galactosidase.
CAZy	GH27. Glycoside Hydrolase Family 27.
Proteomic databases
PRIDE	Q53Y83.
Protocols and materials databases
DNASU	2717.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2717.
KEGG	hsa:2717.
Organism-specific databases
CTD	2717.
PharmGKB	PA28707.
Phylogenomic databases
HOVERGEN	HBG001989.
KO	K01189.
OMA	GYKHMSL.
PhylomeDB	Q53Y83.
Gene expression databases
ArrayExpress	Q53Y83.
Bgee	Q53Y83.
Family and domain databases
Gene3D	2.60.40.1180. 1 hit. 3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR013780. Glyco_hydro_13_b. IPR002241. Glyco_hydro_27. IPR000111. Glyco_hydro_GHD. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Pfam	PF02065. Melibiase. 1 hit. [Graphical view]
PRINTS	PR00740. GLHYDRLASE27.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS00512. ALPHA_GALACTOSIDASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2717.
NextBio	10728.

Entry information

Entry name

Q53Y83_HUMAN

Accession

Primary (citable) accession number: Q53Y83

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.