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Protein

Guanine nucleotide-binding protein subunit gamma

Gene

GNG11

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionTransducerUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gammaUniRule annotation
Gene namesi
Name:GNG11Imported
ORF Names:hCG_19197Imported, tcag7.247Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cell membrane UniRule annotation; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28782.

PTM / Processingi

Keywords - PTMi

LipoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000127920.
ExpressionAtlasiQ53Y01. baseline and differential.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.SAAS annotation
G proteins are composed of 3 units; alpha, beta and gamma.UniRule annotation

Protein-protein interaction databases

IntActiQ53Y01. 3 interactors.
STRINGi9606.ENSP00000248564.

Structurei

3D structure databases

SMRiQ53Y01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 73G protein gammaInterPro annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 46Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the G protein gamma family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
HOVERGENiHBG014983.
KOiK04546.
OMAiMPAINIE.
OrthoDBiEOG091G17J0.
PhylomeDBiQ53Y01.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53Y01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE
60 70
DPLVKGIPED KNPFKEKGSC VIS
Length:73
Mass (Da):8,481
Last modified:May 24, 2005 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007141 mRNA. Translation: AAP35805.1.
AK312037 mRNA. Translation: BAG34974.1.
CH236949 Genomic DNA. Translation: EAL24138.1.
CH471091 Genomic DNA. Translation: EAW76804.1.
RefSeqiNP_004117.1. NM_004126.3.
UniGeneiHs.83381.

Genome annotation databases

GeneIDi2791.
KEGGihsa:2791.
UCSCiuc003und.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007141 mRNA. Translation: AAP35805.1.
AK312037 mRNA. Translation: BAG34974.1.
CH236949 Genomic DNA. Translation: EAL24138.1.
CH471091 Genomic DNA. Translation: EAW76804.1.
RefSeqiNP_004117.1. NM_004126.3.
UniGeneiHs.83381.

3D structure databases

SMRiQ53Y01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ53Y01. 3 interactors.
STRINGi9606.ENSP00000248564.

Protocols and materials databases

DNASUi2791.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2791.
KEGGihsa:2791.
UCSCiuc003und.4. human.

Organism-specific databases

CTDi2791.
PharmGKBiPA28782.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
HOVERGENiHBG014983.
KOiK04546.
OMAiMPAINIE.
OrthoDBiEOG091G17J0.
PhylomeDBiQ53Y01.

Miscellaneous databases

GenomeRNAii2791.

Gene expression databases

BgeeiENSG00000127920.
ExpressionAtlasiQ53Y01. baseline and differential.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53Y01_HUMAN
AccessioniPrimary (citable) accession number: Q53Y01
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: January 18, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.