Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein subunit gamma

Gene

GNG11

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducerUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gammaUniRule annotation
Gene namesi
Name:GNG11Imported
ORF Names:hCG_19197Imported, tcag7.247Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cell membrane UniRule annotation; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28782.

PTM / Processingi

Keywords - PTMi

LipoproteinUniRule annotation

Proteomic databases

MaxQBiQ53Y01.

Expressioni

Gene expression databases

BgeeiENSG00000127920.
ExpressionAtlasiQ53Y01. baseline and differential.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.SAAS annotation
G proteins are composed of 3 units; alpha, beta and gamma.UniRule annotation

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ53Y01. 3 interactors.

Structurei

3D structure databases

SMRiQ53Y01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 73G protein gammaInterPro annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 46Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the G protein gamma family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
HOVERGENiHBG014983.
KOiK04546.
OMAiMPAINIE.
OrthoDBiEOG091G17J0.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiView protein in InterPro
IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiView protein in Pfam
PF00631. G-gamma. 1 hit.
PRINTSiPR00321. GPROTEING.
SMARTiView protein in SMART
SM00224. GGL. 1 hit.
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiView protein in PROSITE
PS50058. G_PROTEIN_GAMMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53Y01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE
60 70
DPLVKGIPED KNPFKEKGSC VIS
Length:73
Mass (Da):8,481
Last modified:May 24, 2005 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007141 mRNA. Translation: AAP35805.1.
AK312037 mRNA. Translation: BAG34974.1.
CH236949 Genomic DNA. Translation: EAL24138.1.
CH471091 Genomic DNA. Translation: EAW76804.1.
RefSeqiNP_004117.1. NM_004126.3.
UniGeneiHs.83381.

Genome annotation databases

GeneIDi2791.
KEGGihsa:2791.
UCSCiuc003und.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ53Y01_HUMAN
AccessioniPrimary (citable) accession number: Q53Y01
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.