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Protein

Muscarinic acetylcholine receptor

Gene

CHRM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptorUniRule annotation
Gene namesi
Name:CHRM1Imported
ORF Names:hCG_2020133Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000168539.3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 50HelicalUniRule annotationAdd BLAST26
Transmembranei62 – 88HelicalUniRule annotationAdd BLAST27
Transmembranei100 – 121HelicalUniRule annotationAdd BLAST22
Transmembranei142 – 167HelicalUniRule annotationAdd BLAST26
Transmembranei187 – 209HelicalUniRule annotationAdd BLAST23
Transmembranei369 – 390HelicalUniRule annotationAdd BLAST22
Transmembranei402 – 421HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotation, Membrane, Postsynaptic cell membraneUniRule annotation, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26484.

Expressioni

Gene expression databases

BgeeiENSG00000168539.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 418G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST377

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
HOVERGENiHBG105720.
KOiK04129.
OMAiRCCRTPR.
OrthoDBiEOG091G06VI.

Family and domain databases

CDDicd15049. 7tmA_mAChR. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002228. Musac_Ach_M1_rcpt.
IPR000995. Musac_Ach_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00538. MUSCRINICM1R.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53XZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF
60 70 80 90 100
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL
110 120 130 140 150
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW
160 170 180 190 200
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP
210 220 230 240 250
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG
260 270 280 290 300
SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV
310 320 330 340 350
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA
360 370 380 390 400
KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW
410 420 430 440 450
ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG
460
SVHRTPSRQC
Length:460
Mass (Da):51,421
Last modified:May 24, 2005 - v1
Checksum:i567C20F63541C8D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007166 mRNA. Translation: AAP35830.1.
AK312374 mRNA. Translation: BAG35292.1.
CH471076 Genomic DNA. Translation: EAW74124.1.
CH471076 Genomic DNA. Translation: EAW74125.1.
CH471076 Genomic DNA. Translation: EAW74126.1.
RefSeqiNP_000729.2. NM_000738.2.
XP_011543044.1. XM_011544742.2.
UniGeneiHs.632119.

Genome annotation databases

GeneIDi1128.
KEGGihsa:1128.
UCSCiuc001nwi.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ53XZ3_HUMAN
AccessioniPrimary (citable) accession number: Q53XZ3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 25, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.