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Protein

Tyrosine-protein phosphatase non-receptor type

Gene

PTPN6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei421SubstrateUniRule annotation1
Active sitei455Phosphocysteine intermediateUniRule annotation1
Binding sitei502SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:PTPN6Imported
ORF Names:hCG_25941Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000111679.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34002

PTM / Processingi

Proteomic databases

MaxQBiQ53XS4
PRIDEiQ53XS4

Expressioni

Gene expression databases

BgeeiENSG00000111679
ExpressionAtlasiQ53XS4 baseline and differential

Structurei

3D structure databases

SMRiQ53XS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 102SH2InterPro annotationAdd BLAST97
Domaini112 – 215SH2InterPro annotationAdd BLAST104
Domaini246 – 517Tyrosine-protein phosphataseInterPro annotationAdd BLAST272
Domaini432 – 508TYR_PHOSPHATASE_2InterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0790 Eukaryota
COG5599 LUCA
HOGENOMiHOG000273907
HOVERGENiHBG000223

Family and domain databases

Gene3Di3.30.505.10, 2 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012152 Tyr_Pase_non-rcpt_typ-6/11
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00017 SH2, 2 hits
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000929 Tyr-Ptase_nr_6, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 2 hits
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001 SH2, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q53XS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRGWFHRD LSGLDAETLL KGRGVHGSFL ARPSRKNQGD FSLSVRVGDQ
60 70 80 90 100
VTHIRIQNSG DFYDLYGGEK FATLTELVEY YTQQQGVLQD RDGTIIHLKY
110 120 130 140 150
PLNCSDPTSE RWYHGHMSGG QAETLLQAKG EPWTFLVRES LSQPGDFVLS
160 170 180 190 200
VLSDQPKAGP GSPLRVTHIK VMCEGGRYTV GGLETFDSLT DLVEHFKKTG
210 220 230 240 250
IEEASGAFVY LRQPYYATRV NAADIENRVL ELNKKQESED TAKAGFWEEF
260 270 280 290 300
ESLQKQEVKN LHQRLEGQRP ENKGKNRYKN ILPFDHSRVI LQGRDSNIPG
310 320 330 340 350
SDYINANYIK NQLLGPDENA KTYIASQGCL EATVNDFWQM AWQENSRVIV
360 370 380 390 400
MTTREVEKGR NKCVPYWPEV GMQRAYGPYS VTNCGEHDTT EYKLRTLQVS
410 420 430 440 450
PLDNGDLIRE IWHYQYLSWP DHGVPSEPGG VLSFLDQINQ RQESLPHAGP
460 470 480 490 500
IIVHCSAGIG RTGTIIVIDM LMENISTKGL DCDIDIQKTI QMVRAQRSGM
510 520 530 540 550
VQTEAQYKFI YVAIAQFIET TKKKLEVLQS QKGQESEYGN ITYPPAMKNA
560 570 580 590
HAKASRTSSK HKEDVYENLH TKNKREEKVK KQRSADKEKS KGSLKRK
Length:597
Mass (Da):67,719
Last modified:May 24, 2005 - v1
Checksum:i6A291A2860159389
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007390 mRNA Translation: AAP36054.1
AK313379 mRNA Translation: BAG36177.1
CH471116 Genomic DNA Translation: EAW88702.1
RefSeqiNP_536858.1, NM_080548.4
XP_011519290.1, XM_011520988.1
UniGeneiHs.63489

Genome annotation databases

GeneIDi5777
UCSCiuc001qsa.1 human

Similar proteinsi

Entry informationi

Entry nameiQ53XS4_HUMAN
AccessioniPrimary (citable) accession number: Q53XS4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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