MAD, mothers against decapentaplegic homolog 2 (Drosophila)

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Unreviewed, UniProtKB/TrEMBL Q53XR6 (Q53XR6_HUMAN)

Last modified February 9, 2010. Version 45. History...

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Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
    MAD, mothers against decapentaplegic homolog 2 (Drosophila) EMBL AAP36090.1
Submitted name:
    SMAD, mothers against DPP homolog 2 (Drosophila), isoform CRA_b EMBL EAW62915.1
    cDNA, FLJ93422, Homo sapiens MAD, mothers against decapentaplegic homolog 2(Drosophila) (MADH2), mRNA EMBL BAG35802.1

Gene names

Name:	SMAD2 EMBL EAW62915.1
ORF Names:	hCG_22544 EMBL EAW62915.1

Organism

Homo sapiens (Human) EMBL AAP36090.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation Spearmint SPM003619
Cellular component	Nucleus Spearmint SPM003619
Gene Ontology (GO)
Biological process	anterior/posterior pattern formation Inferred from sequence or structural similarity. Source: UniProtKB cell fate commitment Inferred from sequence or structural similarity. Source: UniProtKB heart development Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara insulin secretion Inferred from electronic annotation. Source: Compara intracellular signaling cascade Inferred from sequence or structural similarity. Source: UniProtKB lung development Inferred from electronic annotation. Source: Compara mesoderm formation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara organ growth Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara pancreas development Inferred from electronic annotation. Source: Compara paraxial mesoderm morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of epithelial to mesenchymal transition Inferred from electronic annotation. Source: Compara positive regulation of gene-specific transcription Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB post-embryonic development Inferred from electronic annotation. Source: Compara protein amino acid phosphorylation Inferred from electronic annotation. Source: Compara regulation of binding Inferred from sequence or structural similarity. Source: UniProtKB response to glucose stimulus Inferred from electronic annotation. Source: Compara transcription Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: Compara transcription factor complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	double-stranded DNA binding Inferred from sequence or structural similarity. Source: UniProtKB transcription activator activity Inferred from sequence or structural similarity. Source: UniProtKB transcription factor activity Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q53XR6-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 95406DB5FC0AA4C9
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FASTA

467

52,306

        10         20         30         40         50         60 
MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 

        70         80         90        100        110        120 
LEKAITTQNC NTKCVTIPST CSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR 

       130        140        150        160        170        180 
KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV 

       190        200        210        220        230        240 
PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS 

       250        260        270        280        290        300 
MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD 

       310        320        330        340        350        360 
GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP 

       370        380        390        400        410        420 
NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK 

       430        440        450        460 
GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS

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References

[1]	"Cloning of human full-length CDSs in BD Creator(TM) System Donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	BT007422 mRNA. Translation: AAP36090.1. AK312963 mRNA. Translation: BAG35802.1. CH471096 Genomic DNA. Translation: EAW62915.1.
IPI	IPI00019548.
RefSeq	NP_001003652.1. NP_005892.1.
UniGene	Hs.12253 Hs.705764
3D structure databases
SMR	Q53XR6. Positions 7-172, 265-467.
ModBase	Search...
Protein-protein interaction databases
STRING	Q53XR6.
Proteomic databases
PRIDE	Q53XR6.
Genome annotation databases
Ensembl	ENST00000262160; ENSP00000262160; ENSG00000175387; Homo sapiens. [Genome view] ENST00000402690; ENSP00000384449; ENSG00000175387; Homo sapiens. [Genome view]
GeneID	4087.
KEGG	hsa:4087.
Organism-specific databases
CTD	4087.
HGNC	HGNC:6768. SMAD2.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q53XR6.
OMA	WKKSASG.
PhylomeDB	Q53XR6.
Gene expression databases
ArrayExpress	Q53XR6.
Bgee	Q53XR6.
Family and domain databases
InterPro	IPR013790. Dwarfin. IPR003619. MAD_homology1_Dwarfin-type. IPR013019. MAD_homology_MH1. IPR017855. SMAD_dom-like. IPR001132. SMAD_dom_Dwarfin-type. IPR008984. SMAD_FHA_domain. [Graphical view]
Gene3D	G3DSA:3.90.520.10. MAD_MH1. 1 hit. G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit.
PANTHER	PTHR13703. Dwarfin. 1 hit.
Pfam	PF03165. MH1. 1 hit. PF03166. MH2. 1 hit. [Graphical view]
SMART	SM00523. DWA. 1 hit. SM00524. DWB. 1 hit. [Graphical view]
PROSITE	PS51075. MH1. 1 hit. PS51076. MH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	16020.

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Entry information

Entry name

Q53XR6_HUMAN

Accession

Primary (citable) accession number: Q53XR6

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	February 9, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information