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Protein
Submitted name:

VAMP (Vesicle-associated membrane protein)-associated protein B and C

Gene

VAPB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
VAMP (Vesicle-associated membrane protein)-associated protein B and CImported
Submitted name:
VAMP (Vesicle-associated membrane protein)-associated protein B and C, isoform CRA_bImported
Submitted name:
cDNA FLJ13179 fis, clone NT2RP3003918, highly similar to Vesicle-associated membrane protein-associated protein B/CImported
Gene namesi
Name:VAPBImported
ORF Names:hCG_26693Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei224 – 242HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37273.

Expressioni

Gene expression databases

BgeeiENSG00000124164.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

MINTiMINT-5002951.
STRINGi9606.ENSP00000417175.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 124MSPInterPro annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili166 – 193Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0439. Eukaryota.
COG5066. LUCA.
HOVERGENiHBG028551.
KOiK10707.
OMAiAQKEYPQ.
OrthoDBiEOG091G0KJ2.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. VAP.
IPR030226. VapB.
PANTHERiPTHR10809. PTHR10809. 1 hit.
PTHR10809:SF86. PTHR10809:SF86. 1 hit.
PfamiView protein in Pfam
PF00635. Motile_Sperm. 1 hit.
PIRSFiPIRSF019693. VAMP-associated. 1 hit.
SUPFAMiSSF49354. SSF49354. 1 hit.
PROSITEiView protein in PROSITE
PS50202. MSP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53XM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR
60 70 80 90 100
RYCVRPNSGI IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS
110 120 130 140 150
DMEAVWKEAK PEDLMDSKLR CVFELPAEND KPHDVEINKI ISTTASKTET
160 170 180 190 200
PIVSKSLSSS LDDTEVKKVM EECKRLQGEV QRLREENKQF KEEDGLRMRK
210 220 230 240
TVQSNSPISA LAPTGKEEGL STRLLALVVL FFIVGVIIGK IAL
Length:243
Mass (Da):27,228
Last modified:May 24, 2005 - v1
Checksum:i22AEEF9EC7FC0B3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009811 mRNA. Translation: AAP88813.1.
AK023241 mRNA. Translation: BAG51174.1.
CH471077 Genomic DNA. Translation: EAW75494.1.
CH471077 Genomic DNA. Translation: EAW75495.1.
RefSeqiNP_004729.1. NM_004738.4.
UniGeneiHs.182625.

Genome annotation databases

GeneIDi9217.
KEGGihsa:9217.
UCSCiuc002xza.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009811 mRNA. Translation: AAP88813.1.
AK023241 mRNA. Translation: BAG51174.1.
CH471077 Genomic DNA. Translation: EAW75494.1.
CH471077 Genomic DNA. Translation: EAW75495.1.
RefSeqiNP_004729.1. NM_004738.4.
UniGeneiHs.182625.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-5002951.
STRINGi9606.ENSP00000417175.

Protocols and materials databases

DNASUi9217.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9217.
KEGGihsa:9217.
UCSCiuc002xza.4. human.

Organism-specific databases

CTDi9217.
PharmGKBiPA37273.

Phylogenomic databases

eggNOGiKOG0439. Eukaryota.
COG5066. LUCA.
HOVERGENiHBG028551.
KOiK10707.
OMAiAQKEYPQ.
OrthoDBiEOG091G0KJ2.

Miscellaneous databases

ChiTaRSiVAPB. human.
GenomeRNAii9217.

Gene expression databases

BgeeiENSG00000124164.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. VAP.
IPR030226. VapB.
PANTHERiPTHR10809. PTHR10809. 1 hit.
PTHR10809:SF86. PTHR10809:SF86. 1 hit.
PfamiView protein in Pfam
PF00635. Motile_Sperm. 1 hit.
PIRSFiPIRSF019693. VAMP-associated. 1 hit.
SUPFAMiSSF49354. SSF49354. 1 hit.
PROSITEiView protein in PROSITE
PS50202. MSP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ53XM7_HUMAN
AccessioniPrimary (citable) accession number: Q53XM7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 12, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.