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Protein
Submitted name:

VAMP (Vesicle-associated membrane protein)-associated protein B and C

Gene

VAPB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
VAMP (Vesicle-associated membrane protein)-associated protein B and CImported
Submitted name:
VAMP (Vesicle-associated membrane protein)-associated protein B and C, isoform CRA_bImported
Submitted name:
cDNA FLJ13179 fis, clone NT2RP3003918, highly similar to Vesicle-associated membrane protein-associated protein B/CImported
Gene namesi
Name:VAPBImported
ORF Names:hCG_26693Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000124164.15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei224 – 242HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37273

Expressioni

Gene expression databases

BgeeiENSG00000124164

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 124MSPInterPro annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili166 – 193Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
HOVERGENiHBG028551
KOiK10707
OMAiPHDIEIN
OrthoDBiEOG091G0KJ2

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
IPR030226 VapB
PANTHERiPTHR10809 PTHR10809, 1 hit
PTHR10809:SF12 PTHR10809:SF12, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
PIRSFiPIRSF019693 VAMP-associated, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit

Sequencei

Sequence statusi: Complete.

Q53XM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR
60 70 80 90 100
RYCVRPNSGI IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS
110 120 130 140 150
DMEAVWKEAK PEDLMDSKLR CVFELPAEND KPHDVEINKI ISTTASKTET
160 170 180 190 200
PIVSKSLSSS LDDTEVKKVM EECKRLQGEV QRLREENKQF KEEDGLRMRK
210 220 230 240
TVQSNSPISA LAPTGKEEGL STRLLALVVL FFIVGVIIGK IAL
Length:243
Mass (Da):27,228
Last modified:May 24, 2005 - v1
Checksum:i22AEEF9EC7FC0B3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009811 mRNA Translation: AAP88813.1
AK023241 mRNA Translation: BAG51174.1
CH471077 Genomic DNA Translation: EAW75494.1
CH471077 Genomic DNA Translation: EAW75495.1
RefSeqiNP_004729.1, NM_004738.4
UniGeneiHs.182625

Genome annotation databases

GeneIDi9217
KEGGihsa:9217
UCSCiuc002xza.4 human

Similar proteinsi

Entry informationi

Entry nameiQ53XM7_HUMAN
AccessioniPrimary (citable) accession number: Q53XM7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health