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Protein
Submitted name:

Proteasome (Prosome, macropain) 26S subunit, ATPase, 1

Gene

PSMC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Proteasome (Prosome, macropain) 26S subunit, ATPase, 1Imported
Submitted name:
Proteasome (Prosome, macropain) 26S subunit, ATPase, 1, isoform CRA_aImported
Submitted name:
Proteasome 26S ATPase subunit 1Imported
Submitted name:
cDNA, FLJ93843, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1(PSMC1), mRNAImported
Gene namesi
Name:PSMC1Imported
ORF Names:hCG_2029049Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

ProteasomeImported

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33892.

PTM / Processingi

Proteomic databases

MaxQBiQ53XL8.

Expressioni

Gene expression databases

BgeeiENSG00000100764.
ExpressionAtlasiQ53XL8. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ53XL8. 2 interactors.

Structurei

3D structure databases

SMRiQ53XL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 357AAAInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0726. Eukaryota.
COG1222. LUCA.
HOVERGENiHBG000109.
KOiK03062.
OMAiNATFIRV.
OrthoDBiEOG091G07NC.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53XL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQSQSGGHG PGGGKKDDKD KKKKYEPPVP TRVGKKKKKT KGPDAASKLP
60 70 80 90 100
LVTPHTQCRL KLLKLERIKD YLLMEEEFIR NQEQMKPLEE KQEEERSKVD
110 120 130 140 150
DLRGTPMSVG TLEEIIDDNH AIVSTSVGSE HYVSILSFVD KDLLEPGCSV
160 170 180 190 200
LLNHKVHAVI GVLMDDTDPL VTVMKVEKAP QETYADIGGL DNQIQEIKES
210 220 230 240 250
VELPLTHPEY YEEMGIKPPK GVILYGPPGT GKTLLAKAVA NQTSATFLRV
260 270 280 290 300
VGSELIQKYL GDGPKLVREL FRVAEEHAPS IVFIDEIDAI GTKRYDSNSG
310 320 330 340 350
GEREIQRTML ELLNQLDGFD SRGDVKVIMA TNRIETLDPA LIRPGRIDRK
360 370 380 390 400
IEFPLPDEKT KKRIFQIHTS RMTLADDVTL DDLIMAKDDL SGADIKAICT
410 420 430 440
EAGLMALRER RMKVTNEDFK KSKENVLYKK QEGTPEGLYL
Length:440
Mass (Da):49,185
Last modified:May 24, 2005 - v1
Checksum:iACA80782F4F96F49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei440Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009826 mRNA. Translation: AAP88828.1.
AK313325 mRNA. Translation: BAG36130.1.
AB451311 mRNA. Translation: BAG70125.1.
AB451441 mRNA. Translation: BAG70255.1.
CH471061 Genomic DNA. Translation: EAW81419.1.
RefSeqiNP_002793.2. NM_002802.2.
UniGeneiHs.356654.
Hs.476697.

Genome annotation databases

GeneIDi5700.
KEGGihsa:5700.
UCSCiuc001xyf.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ53XL8_HUMAN
AccessioniPrimary (citable) accession number: Q53XL8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 5, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.