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Protein
Submitted name:

CASP2 and RIPK1 domain containing adaptor with death domain

Gene

CRADD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CASP2 and RIPK1 domain containing adaptor with death domainImported
Submitted name:
CRADD proteinImported
Submitted name:
cDNA, FLJ95760, Homo sapiens CASP2 and RIPK1 domain containing adaptor with deathdomain (CRADD), mRNAImported
Gene namesi
Name:CRADDImported
ORF Names:hCG_40089Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26860.

PTM / Processingi

Proteomic databases

MaxQBiQ53XL1.

Expressioni

Gene expression databases

BgeeiENSG00000169372.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327647.

Structurei

3D structure databases

SMRiQ53XL1. Positions 1-100, 109-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7878CARDInterPro annotationAdd
BLAST
Domaini116 – 18873DeathInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IJAM. Eukaryota.
ENOG4111SYE. LUCA.
HOVERGENiHBG051112.
KOiK02832.
OMAiLGPEWEH.
OrthoDBiEOG091G0M3P.
PhylomeDBiQ53XL1.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
SM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50209. CARD. 1 hit.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53XL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG
60 70 80 90 100
LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG
110 120 130 140 150
DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA
160 170 180 190
NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
Length:199
Mass (Da):22,745
Last modified:May 24, 2005 - v1
Checksum:i3437CC612C85E402
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei199 – 1991Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009837 mRNA. Translation: AAP88839.1.
AK314861 mRNA. Translation: BAG37377.1.
CR407643 mRNA. Translation: CAG28571.1.
CH471054 Genomic DNA. Translation: EAW97497.1.
RefSeqiNP_001307028.1. NM_001320099.1.
NP_003796.1. NM_003805.4.
UniGeneiHs.38533.
Hs.591016.
Hs.660031.
Hs.719191.

Genome annotation databases

GeneIDi8738.
KEGGihsa:8738.
UCSCiuc001tda.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009837 mRNA. Translation: AAP88839.1.
AK314861 mRNA. Translation: BAG37377.1.
CR407643 mRNA. Translation: CAG28571.1.
CH471054 Genomic DNA. Translation: EAW97497.1.
RefSeqiNP_001307028.1. NM_001320099.1.
NP_003796.1. NM_003805.4.
UniGeneiHs.38533.
Hs.591016.
Hs.660031.
Hs.719191.

3D structure databases

SMRiQ53XL1. Positions 1-100, 109-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327647.

Proteomic databases

MaxQBiQ53XL1.

Protocols and materials databases

DNASUi8738.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8738.
KEGGihsa:8738.
UCSCiuc001tda.4. human.

Organism-specific databases

CTDi8738.
PharmGKBiPA26860.

Phylogenomic databases

eggNOGiENOG410IJAM. Eukaryota.
ENOG4111SYE. LUCA.
HOVERGENiHBG051112.
KOiK02832.
OMAiLGPEWEH.
OrthoDBiEOG091G0M3P.
PhylomeDBiQ53XL1.

Miscellaneous databases

ChiTaRSiCRADD. human.
GenomeRNAii8738.

Gene expression databases

BgeeiENSG00000169372.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
SM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50209. CARD. 1 hit.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53XL1_HUMAN
AccessioniPrimary (citable) accession number: Q53XL1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.