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Protein
Submitted name:

CASP2 and RIPK1 domain containing adaptor with death domain

Gene

CRADD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
CASP2 and RIPK1 domain containing adaptor with death domainImported
Submitted name:
CRADD proteinImported
Submitted name:
cDNA, FLJ95760, Homo sapiens CASP2 and RIPK1 domain containing adaptor with deathdomain (CRADD), mRNAImported
Gene namesi
Name:CRADDImported
ORF Names:hCG_40089Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000169372.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26860

PTM / Processingi

Proteomic databases

MaxQBiQ53XL1

Expressioni

Gene expression databases

BgeeiENSG00000169372
ExpressionAtlasiQ53XL1 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ53XL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 78CARDInterPro annotationAdd BLAST78
Domaini116 – 188DeathInterPro annotationAdd BLAST73

Phylogenomic databases

eggNOGiENOG410IJAM Eukaryota
ENOG4111SYE LUCA
HOVERGENiHBG051112
KOiK02832
OMAiLGPEWEH
OrthoDBiEOG091G0M3P

Family and domain databases

CDDicd08319 Death_RAIDD, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR037939 CRADD
IPR037926 CRADD_Death
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PANTHERiPTHR15034 PTHR15034, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF00531 Death, 1 hit
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50017 DEATH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q53XL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG
60 70 80 90 100
LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG
110 120 130 140 150
DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA
160 170 180 190
NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
Length:199
Mass (Da):22,745
Last modified:May 24, 2005 - v1
Checksum:i3437CC612C85E402
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei199Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009837 mRNA Translation: AAP88839.1
AK314861 mRNA Translation: BAG37377.1
CR407643 mRNA Translation: CAG28571.1
CH471054 Genomic DNA Translation: EAW97497.1
RefSeqiNP_001307028.1, NM_001320099.1
NP_001317055.1, NM_001330126.1
NP_003796.1, NM_003805.4
UniGeneiHs.38533
Hs.591016
Hs.660031
Hs.719191

Genome annotation databases

GeneIDi8738
KEGGihsa:8738
UCSCiuc001tda.4 human

Similar proteinsi

Entry informationi

Entry nameiQ53XL1_HUMAN
AccessioniPrimary (citable) accession number: Q53XL1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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