Q53XJ8 (Q53XJ8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Coagulation factor II (Thrombin) receptor-like 1 EMBL AAP88858.1

Submitted name:
Protease-activated receptor 2 EMBL AAP97012.1

Gene names

Name:	F2RL1 EMBL EAW95782.1
ORF Names:	hCG_37059 EMBL EAW95782.1

Organism

Homo sapiens (Human) EMBL AAP88858.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Hydrolase Protease EMBL AAP97012.1 Receptor EMBL AAP88858.1
Gene Ontology (GO)
Biological process	blood coagulation Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW thrombin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q53XJ8 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: F1A4E1D5AB9B362B	FASTA	397	44,126
	10 20 30 40 50 60 MRSPSAAWLL GAAILLAASL SCSGTIQGTN RSSKGRSLIG KVDGTSHVTG KGVTVETVFS 70 80 90 100 110 120 VDEFSASVLT GKLTTVFLPI VYTIVFVVGL PSNGMALWVF LFRTKKKHPA VIYMANLALA 130 140 150 160 170 180 DLLSVIWFPL KIAYHIHGNN WIYGEALCNV LIGFFYGNMY CSILFMTCLS VQRYWVIVNP 190 200 210 220 230 240 MGHSRKKANI AIGISLAIWL LILLVTIPLY VVKQTIFIPA LNITTCHDVL PEQLLVGDMF 250 260 270 280 290 300 NYFLSLAIGV FLFPAFLTAS AYVLMIRMLR SSAMDENSEK KRKRAIKLIV TVLAMYLICF 310 320 330 340 350 360 TPSNLLLVVH YFLIKSQGQS HVYALYIVAL CLSTLNSCID PFVYYFVSHD FRDHAKNALL 370 380 390 CRSVRTVKQM QVSLTSKKHS RKSSSYSSSS TTVKTSY

References

[1]	Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1." Luo W., Wang Y., Hanck T., Stricker R., Reiser G. J. Biol. Chem. 281:7927-7936(2006) [PubMed: 16410250] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT009856 mRNA. Translation: AAP88858.1. AY336105 mRNA. Translation: AAP97012.1. CH471084 Genomic DNA. Translation: EAW95782.1.
IPI	IPI00296446.
RefSeq	NP_005233.3. NM_005242.4.
UniGene	Hs.154299.
3D structure databases
ProteinModelPortal	Q53XJ8.
SMR	Q53XJ8. Positions 160-190, 326-361.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1326650.
STRING	Q53XJ8.
Proteomic databases
PRIDE	Q53XJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2150.
KEGG	hsa:2150.
Organism-specific databases
CTD	2150.
Phylogenomic databases
GeneTree	ENSGT00600000084316.
HOVERGEN	HBG105658.
Gene expression databases
ArrayExpress	Q53XJ8.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002281. Pro_rcpt_2. IPR003912. Protea_act_rcpt. [Graphical view]
KO	K04234.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01428. PROTEASEAR. PR01152. PROTEASEAR2.
PROSITE	PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	8689.

Entry information

Entry name

Q53XJ8_HUMAN

Accession

Primary (citable) accession number: Q53XJ8

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.