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Protein
Submitted name:

Full-length cDNA clone CS0DI011YN22 of Placenta of Homo sapiens (human)

Gene

LGMN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei148UniRule annotation1
Active sitei189NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Full-length cDNA clone CS0DI011YN22 of Placenta of Homo sapiens (human)Imported
Submitted name:
Legumain, isoform CRA_aImported
Submitted name:
cDNA FLJ78453, highly similar to Homo sapiens legumain (LGMN), transcript variant 2, mRNAImported
Gene namesi
Name:LGMNImported
ORF Names:hCG_21254Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000100600.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30354

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501430952718 – 433Sequence analysisAdd BLAST416

Expressioni

Gene expression databases

BgeeiENSG00000100600

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1348 Eukaryota
COG5206 LUCA
HOVERGENiHBG031304
KOiK01369
OMAiKVMQFQG
OrthoDBiEOG091G08C5

Family and domain databases

InterProiView protein in InterPro
IPR001096 Peptidase_C13
PANTHERiPTHR12000 PTHR12000, 1 hit
PfamiView protein in Pfam
PF01650 Peptidase_C13, 1 hit
PIRSFiPIRSF019663 Legumain, 1 hit
PRINTSiPR00776 HEMOGLOBNASE

Sequencei

Sequence statusi: Complete.

Q53XC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWKVAVFLS VALGIGAVPI DDPEDGGKHW VVIVAGSNGW YNYRHQADAC
60 70 80 90 100
HAYQIIHRNG IPDEQIVVMM YDDIAYSEDN PTPGIVINRP NGTDVYQGVP
110 120 130 140 150
KDYTGEDVTP QNFLAVLRGD AEAVKGIGSG KVLKSGPQDH VFIYFTDHGS
160 170 180 190 200
TGILVFPNED LHVKDLNETI HYMYKHKMYR KMVFYIEACE SGSMMNHLPD
210 220 230 240 250
NINVYATTAA NPRESSYACY YDEKRSTYLG DWYSVNWMED SDVEDLTKET
260 270 280 290 300
LHKQYHLVKS HTNTSHVMQY GNKTISTMKV MQFQGMKRKA SSPVPLPPVT
310 320 330 340 350
HLDLTPSPDV PLTIMKRKLM NTNDLEESRQ LTEEIQRHLD ARHLIEKSVR
360 370 380 390 400
KIVSLLAASE AEVEQLLSER APLTGHSCYP EALLHFRTHC FNWHSPTYEY
410 420 430
ALRHLYVLVN LCEKPYPLHR IKLSMDHVCL GHY
Length:433
Mass (Da):49,411
Last modified:May 24, 2005 - v1
Checksum:i081AD2D0D584E72A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291560 mRNA Translation: BAF84249.1
BX161434 mRNA Translation: CAD61906.1
CH471061 Genomic DNA Translation: EAW81500.1
CH471061 Genomic DNA Translation: EAW81501.1
RefSeqiNP_001008530.1, NM_001008530.2
NP_005597.3, NM_005606.6
XP_016876952.1, XM_017021463.1
XP_016876953.1, XM_017021464.1
XP_016876954.1, XM_017021465.1
UniGeneiHs.18069

Genome annotation databases

GeneIDi5641
KEGGihsa:5641

Similar proteinsi

Entry informationi

Entry nameiQ53XC6_HUMAN
AccessioniPrimary (citable) accession number: Q53XC6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health