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Protein
Submitted name:

Bone morphogenetic protein 4

Gene

BMP4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Bone morphogenetic protein 4Imported
Submitted name:
Bone morphogenetic protein 4, isoform CRA_aImported
Submitted name:
Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human)Imported
Submitted name:
Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human)Imported
Gene namesi
Name:BMP4Imported
ORF Names:hCG_20967Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500878072425 – 408Sequence analysisAdd BLAST384

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000125378.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000245451.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 408TGF_BETA_2InterPro annotationAdd BLAST123

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOVERGENiHBG004860.
KOiK04662.
OMAiTRLVRHN.
OrthoDBiEOG091G0K7Z.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53XC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS
60 70 80 90 100
HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH
110 120 130 140 150
STGLEYPERP ASRANTVRSF HHEEHLENIP GTSENSAFRF LFNLSSIPEN
160 170 180 190 200
EVISSAELRL FREQVDQGPD WERGFHRINI YEVMKPPAEV VPGHLITRLL
210 220 230 240 250
DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH LHQTRTHQGQ
260 270 280 290 300
HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR
310 320 330 340 350
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN
360 370 380 390 400
STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM

VVEGCGCR
Length:408
Mass (Da):46,555
Last modified:May 24, 2005 - v1
Checksum:i79B01179DBB98204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU518936 Genomic DNA. Translation: ACB21039.1.
BX161385 mRNA. Translation: CAD61876.1.
BX161438 mRNA. Translation: CAD61909.1.
CH471061 Genomic DNA. Translation: EAW80628.1.
CH471061 Genomic DNA. Translation: EAW80629.1.
CH471061 Genomic DNA. Translation: EAW80630.1.
CH471061 Genomic DNA. Translation: EAW80631.1.
RefSeqiNP_001193.2. NM_001202.4.
NP_570911.2. NM_130850.3.
XP_005268072.1. XM_005268015.4.
XP_016877092.1. XM_017021603.1.
UniGeneiHs.68879.

Genome annotation databases

GeneIDi652.
KEGGihsa:652.
UCSCiuc001xal.6. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU518936 Genomic DNA. Translation: ACB21039.1.
BX161385 mRNA. Translation: CAD61876.1.
BX161438 mRNA. Translation: CAD61909.1.
CH471061 Genomic DNA. Translation: EAW80628.1.
CH471061 Genomic DNA. Translation: EAW80629.1.
CH471061 Genomic DNA. Translation: EAW80630.1.
CH471061 Genomic DNA. Translation: EAW80631.1.
RefSeqiNP_001193.2. NM_001202.4.
NP_570911.2. NM_130850.3.
XP_005268072.1. XM_005268015.4.
XP_016877092.1. XM_017021603.1.
UniGeneiHs.68879.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000245451.

Protocols and materials databases

DNASUi652.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi652.
KEGGihsa:652.
UCSCiuc001xal.6. human.

Organism-specific databases

CTDi652.
PharmGKBiPA25381.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOVERGENiHBG004860.
KOiK04662.
OMAiTRLVRHN.
OrthoDBiEOG091G0K7Z.

Miscellaneous databases

GenomeRNAii652.

Gene expression databases

BgeeiENSG00000125378.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53XC5_HUMAN
AccessioniPrimary (citable) accession number: Q53XC5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.