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Protein
Submitted name:

Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, isoform CRA_a

Gene

EIF2S1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorImported
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, isoform CRA_aImported
Submitted name:
Full-length cDNA clone CS0DL010YH08 of B cells (Ramos cell line) of Homo sapiens (human)Imported
Submitted name:
cDNA, FLJ92791, Homo sapiens eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (EIF2S1), mRNAImported
Gene namesi
Name:EIF2S1Imported
ORF Names:hCG_21909Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000134001.12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27695.

PTM / Processingi

Proteomic databases

MaxQBiQ53XC0.

Expressioni

Gene expression databases

BgeeiENSG00000134001.

Interactioni

Protein-protein interaction databases

MINTiMINT-5000593.

Structurei

3D structure databases

SMRiQ53XC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 88S1 motifInterPro annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili283 – 310Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2916. Eukaryota.
COG1093. LUCA.
HOGENOMiHOG000199476.
HOVERGENiHBG001910.
KOiK03237.
OMAiKDVNEHQ.
OrthoDBiEOG091G07NN.

Family and domain databases

Gene3Di1.10.150.190. 1 hit.
3.30.70.1130. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle_sf.
IPR011488. TIF_2_asu.
PANTHERiPTHR10602. PTHR10602. 1 hit.
PfamiView protein in Pfam
PF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
SMARTiView protein in SMART
SM00316. S1. 1 hit.
SUPFAMiSSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiView protein in PROSITE
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53XC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE
60 70 80 90 100
LSRRRIRSIN KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED
110 120 130 140 150
KFTKSKTVYS ILRHVAEVLE YTKDEQLESL FQRTAWVFDD KYKRPGYGAY
160 170 180 190 200
DAFKHAVSDP SILDSLDLNE DEREVLINNI NRRLTPQAVK IRADIEVACY
210 220 230 240 250
GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT TLERTEGLSV
260 270 280 290 300
LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV
310
DGDDDAEEME AKAED
Length:315
Mass (Da):36,112
Last modified:May 24, 2005 - v1
Checksum:iFF3E75E3816E6B1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312442 mRNA. Translation: BAG35351.1.
BX161521 mRNA. Translation: CAD61953.1.
CH471061 Genomic DNA. Translation: EAW80933.1.
CH471061 Genomic DNA. Translation: EAW80934.1.
RefSeqiNP_004085.1. NM_004094.4.
UniGeneiHs.151777.

Genome annotation databases

GeneIDi1965.
KEGGihsa:1965.
UCSCiuc001xjg.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ53XC0_HUMAN
AccessioniPrimary (citable) accession number: Q53XC0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.