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Q53WZ3

- Q53WZ3_MOUSE

UniProt

Q53WZ3 - Q53WZ3_MOUSE

Protein
Submitted name:

Ras

Gene

Ki-ras

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. GDP binding Source: Ensembl
    2. GMP binding Source: Ensembl
    3. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic process Source: Ensembl
    2. cell cycle arrest Source: Ensembl
    3. cellular senescence Source: Ensembl
    4. cytokine-mediated signaling pathway Source: Ensembl
    5. GTP catabolic process Source: InterPro
    6. mitotic cell cycle checkpoint Source: Ensembl
    7. negative regulation of cell proliferation Source: Ensembl
    8. negative regulation of gene expression Source: Ensembl
    9. negative regulation of Rho GTPase activity Source: Ensembl
    10. positive regulation of actin cytoskeleton reorganization Source: Ensembl
    11. positive regulation of cell migration Source: Ensembl
    12. positive regulation of DNA replication Source: Ensembl
    13. positive regulation of epithelial cell proliferation Source: Ensembl
    14. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    15. positive regulation of JNK cascade Source: Ensembl
    16. positive regulation of MAP kinase activity Source: Ensembl
    17. positive regulation of miRNA metabolic process Source: Ensembl
    18. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    19. positive regulation of nitric-oxide synthase activity Source: Ensembl
    20. positive regulation of Rac GTPase activity Source: Ensembl
    21. positive regulation of Ras protein signal transduction Source: Ensembl
    22. positive regulation of ruffle assembly Source: Ensembl
    23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. positive regulation of wound healing Source: Ensembl
    25. protein heterooligomerization Source: Ensembl
    26. Ras protein signal transduction Source: Ensembl
    27. response to glucocorticoid Source: Ensembl
    28. response to mineralocorticoid Source: Ensembl
    29. social behavior Source: Ensembl

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188185. DAP12 signaling.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188530. FCERI mediated MAPK activation.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188578. Signaling by SCF-KIT.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196455. Signaling by FGFR mutants.
    REACT_198350. EGFR Transactivation by Gastrin.
    REACT_199122. Activation of RAS in B cells.
    REACT_199123. Signaling by constitutively active EGFR.
    REACT_207601. p38MAPK events.
    REACT_211860. Tie2 Signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    RasImported
    Gene namesi
    Name:Ki-rasImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. membrane raft Source: Ensembl
    3. mitochondrion Source: Ensembl
    4. plasma membrane Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ53WZ3.
    BgeeiQ53WZ3.
    GenevestigatoriQ53WZ3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ53WZ3.
    SMRiQ53WZ3. Positions 1-37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ53WZ3.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q53WZ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIE                 37
    Length:37
    Mass (Da):4,037
    Last modified:May 24, 2005 - v1
    Checksum:iAAA5B411D73D686A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei37 – 371Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S39586 Genomic DNA. Translation: AAO46052.1.
    UniGeneiMm.383182.
    Mm.400954.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S39586 Genomic DNA. Translation: AAO46052.1 .
    UniGenei Mm.383182.
    Mm.400954.

    3D structure databases

    ProteinModelPortali Q53WZ3.
    SMRi Q53WZ3. Positions 1-37.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    InParanoidi Q53WZ3.

    Enzyme and pathway databases

    Reactomei REACT_188185. DAP12 signaling.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188530. FCERI mediated MAPK activation.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188578. Signaling by SCF-KIT.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196455. Signaling by FGFR mutants.
    REACT_198350. EGFR Transactivation by Gastrin.
    REACT_199122. Activation of RAS in B cells.
    REACT_199123. Signaling by constitutively active EGFR.
    REACT_207601. p38MAPK events.
    REACT_211860. Tie2 Signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    ChiTaRSi KRAS. mouse.

    Gene expression databases

    ArrayExpressi Q53WZ3.
    Bgeei Q53WZ3.
    Genevestigatori Q53WZ3.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids."
      You M., Wang Y., Stoner G., You L., Maronpot R., Reynolds S.H., Anderson M.
      Proc. Natl. Acad. Sci. U.S.A. 89:5804-5808(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C3H/HeJImported.

    Entry informationi

    Entry nameiQ53WZ3_MOUSE
    AccessioniPrimary (citable) accession number: Q53WZ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)