Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q53WZ3

- Q53WZ3_MOUSE

UniProt

Q53WZ3 - Q53WZ3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Ras

Gene

Ki-ras

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GMP binding Source: Ensembl
  3. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. cellular senescence Source: Ensembl
  4. cytokine-mediated signaling pathway Source: Ensembl
  5. GTP catabolic process Source: InterPro
  6. mitotic cell cycle checkpoint Source: Ensembl
  7. negative regulation of cell proliferation Source: Ensembl
  8. negative regulation of gene expression Source: Ensembl
  9. negative regulation of Rho GTPase activity Source: Ensembl
  10. positive regulation of actin cytoskeleton reorganization Source: Ensembl
  11. positive regulation of cell migration Source: Ensembl
  12. positive regulation of DNA replication Source: Ensembl
  13. positive regulation of epithelial cell proliferation Source: Ensembl
  14. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  15. positive regulation of JNK cascade Source: Ensembl
  16. positive regulation of MAP kinase activity Source: Ensembl
  17. positive regulation of miRNA metabolic process Source: Ensembl
  18. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  19. positive regulation of nitric-oxide synthase activity Source: Ensembl
  20. positive regulation of Rac GTPase activity Source: Ensembl
  21. positive regulation of Ras protein signal transduction Source: Ensembl
  22. positive regulation of ruffle assembly Source: Ensembl
  23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. positive regulation of wound healing Source: Ensembl
  25. protein heterooligomerization Source: Ensembl
  26. Ras protein signal transduction Source: Ensembl
  27. response to glucocorticoid Source: Ensembl
  28. response to mineralocorticoid Source: Ensembl
  29. social behavior Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188185. DAP12 signaling.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188578. Signaling by SCF-KIT.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196455. Signaling by FGFR mutants.
REACT_198350. EGFR Transactivation by Gastrin.
REACT_199122. Activation of RAS in B cells.
REACT_199123. Signaling by constitutively active EGFR.
REACT_207601. p38MAPK events.
REACT_211860. Tie2 Signaling.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
RasImported
Gene namesi
Name:Ki-rasImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. membrane raft Source: Ensembl
  4. mitochondrion Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ53WZ3.
ExpressionAtlasiQ53WZ3. baseline and differential.
GenevestigatoriQ53WZ3.

Structurei

3D structure databases

ProteinModelPortaliQ53WZ3.
SMRiQ53WZ3. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q53WZ3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIE
Length:37
Mass (Da):4,037
Last modified:May 24, 2005 - v1
Checksum:iAAA5B411D73D686A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei37 – 371Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S39586 Genomic DNA. Translation: AAO46052.1.
UniGeneiMm.383182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S39586 Genomic DNA. Translation: AAO46052.1 .
UniGenei Mm.383182.

3D structure databases

ProteinModelPortali Q53WZ3.
SMRi Q53WZ3. Positions 1-37.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

Reactomei REACT_188185. DAP12 signaling.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188578. Signaling by SCF-KIT.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196455. Signaling by FGFR mutants.
REACT_198350. EGFR Transactivation by Gastrin.
REACT_199122. Activation of RAS in B cells.
REACT_199123. Signaling by constitutively active EGFR.
REACT_207601. p38MAPK events.
REACT_211860. Tie2 Signaling.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

ChiTaRSi KRAS. mouse.

Gene expression databases

Bgeei Q53WZ3.
ExpressionAtlasi Q53WZ3. baseline and differential.
Genevestigatori Q53WZ3.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids."
    You M., Wang Y., Stoner G., You L., Maronpot R., Reynolds S.H., Anderson M.
    Proc. Natl. Acad. Sci. U.S.A. 89:5804-5808(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/HeJImported.

Entry informationi

Entry nameiQ53WZ3_MOUSE
AccessioniPrimary (citable) accession number: Q53WZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)