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Protein

5'-nucleotidase SurE

Gene

surE

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Divalent metal cationUniRule annotation
Metal bindingi9 – 91Divalent metal cationUniRule annotation
Metal bindingi39 – 391Divalent metal cationUniRule annotation
Metal bindingi96 – 961Divalent metal cationUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-2093-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
5'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation)
Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:TTHB070
Encoded oniPlasmid pTT270 Publication
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Plasmid pTT27

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2442445'-nucleotidase SurEPRO_0000235662Add
BLAST

Structurei

Secondary structure

1
244
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Helixi14 – 2310Combined sources
Turni24 – 263Combined sources
Beta strandi27 – 348Combined sources
Beta strandi51 – 555Combined sources
Beta strandi67 – 726Combined sources
Helixi74 – 8411Combined sources
Beta strandi90 – 989Combined sources
Helixi102 – 1076Combined sources
Helixi109 – 11911Combined sources
Beta strandi123 – 1297Combined sources
Beta strandi132 – 1343Combined sources
Helixi138 – 15215Combined sources
Beta strandi160 – 1645Combined sources
Beta strandi171 – 1744Combined sources
Beta strandi186 – 1905Combined sources
Beta strandi192 – 1943Combined sources
Beta strandi196 – 2005Combined sources
Beta strandi203 – 2064Combined sources
Helixi213 – 2186Combined sources
Beta strandi221 – 2277Combined sources
Helixi234 – 2363Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E69X-ray2.20A/B/C/D1-244[»]
2E6BX-ray2.50A/B/C/D1-244[»]
2E6CX-ray2.05A/B/C/D1-244[»]
2E6EX-ray2.50A/B/C/D1-244[»]
2E6GX-ray2.60A/B/C/D/E/F/G/H/I/J/K/L1-244[»]
2E6HX-ray2.10A/B/C/D1-244[»]
ProteinModelPortaliQ53W92.
SMRiQ53W92. Positions 1-243.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53W92.

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000122501.
KOiK03787.
OMAiAITIAHP.
PhylomeDBiQ53W92.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53W92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILVTNDDG IYSPGLWALA EAASQFGEVF VAAPDTEQSA AGHAITIAHP
60 70 80 90 100
VRAYPHPSPL HAPHFPAYRV RGTPADCVAL GLHLFGPVDL VLSGVNLGSN
110 120 130 140 150
LGHEIWHSGT VAAAKQGYLF GLSAAAFSVP LNGEVPDFAG LRPWLLRTLE
160 170 180 190 200
TLLRLERPFL VNVNLPLRPK GFLWTRQSVR AYEGVVIPGE DPMGRPFYWF
210 220 230 240
APRPLKEAEE GTDRWAVAQG FVSATPLRLD LTDETRLQPT LAHD
Length:244
Mass (Da):26,597
Last modified:May 24, 2005 - v1
Checksum:i9D45179793B5F5BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008227 Genomic DNA. Translation: BAD71866.1.
RefSeqiWP_011229220.1. NC_006462.1.
YP_145309.1. NC_006462.1.

Genome annotation databases

EnsemblBacteriaiBAD71866; BAD71866; BAD71866.
GeneIDi3169602.
KEGGittj:TTHB070.
PATRICi23959066. VBITheThe93045_2014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008227 Genomic DNA. Translation: BAD71866.1.
RefSeqiWP_011229220.1. NC_006462.1.
YP_145309.1. NC_006462.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E69X-ray2.20A/B/C/D1-244[»]
2E6BX-ray2.50A/B/C/D1-244[»]
2E6CX-ray2.05A/B/C/D1-244[»]
2E6EX-ray2.50A/B/C/D1-244[»]
2E6GX-ray2.60A/B/C/D/E/F/G/H/I/J/K/L1-244[»]
2E6HX-ray2.10A/B/C/D1-244[»]
ProteinModelPortaliQ53W92.
SMRiQ53W92. Positions 1-243.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71866; BAD71866; BAD71866.
GeneIDi3169602.
KEGGittj:TTHB070.
PATRICi23959066. VBITheThe93045_2014.

Phylogenomic databases

HOGENOMiHOG000122501.
KOiK03787.
OMAiAITIAHP.
PhylomeDBiQ53W92.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-2093-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ53W92.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSURE_THET8
AccessioniPrimary (citable) accession number: Q53W92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.