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Protein

5'-nucleotidase SurE

Gene

surE

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Divalent metal cationUniRule annotation1
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi39Divalent metal cationUniRule annotation1
Metal bindingi96Divalent metal cationUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation)
Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:TTHB070
Encoded oniPlasmid pTT270 Publication
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Plasmid pTT27

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002356621 – 2445'-nucleotidase SurEAdd BLAST244

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi14 – 23Combined sources10
Turni24 – 26Combined sources3
Beta strandi27 – 34Combined sources8
Beta strandi51 – 55Combined sources5
Beta strandi67 – 72Combined sources6
Helixi74 – 84Combined sources11
Beta strandi90 – 98Combined sources9
Helixi102 – 107Combined sources6
Helixi109 – 119Combined sources11
Beta strandi123 – 129Combined sources7
Beta strandi132 – 134Combined sources3
Helixi138 – 152Combined sources15
Beta strandi160 – 164Combined sources5
Beta strandi171 – 174Combined sources4
Beta strandi186 – 190Combined sources5
Beta strandi192 – 194Combined sources3
Beta strandi196 – 200Combined sources5
Beta strandi203 – 206Combined sources4
Helixi213 – 218Combined sources6
Beta strandi221 – 227Combined sources7
Helixi234 – 236Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E69X-ray2.20A/B/C/D1-244[»]
2E6BX-ray2.50A/B/C/D1-244[»]
2E6CX-ray2.05A/B/C/D1-244[»]
2E6EX-ray2.50A/B/C/D1-244[»]
2E6GX-ray2.60A/B/C/D/E/F/G/H/I/J/K/L1-244[»]
2E6HX-ray2.10A/B/C/D1-244[»]
ProteinModelPortaliQ53W92.
SMRiQ53W92.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53W92.

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000122501.
KOiK03787.
OMAiAITIAHP.
PhylomeDBiQ53W92.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53W92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILVTNDDG IYSPGLWALA EAASQFGEVF VAAPDTEQSA AGHAITIAHP
60 70 80 90 100
VRAYPHPSPL HAPHFPAYRV RGTPADCVAL GLHLFGPVDL VLSGVNLGSN
110 120 130 140 150
LGHEIWHSGT VAAAKQGYLF GLSAAAFSVP LNGEVPDFAG LRPWLLRTLE
160 170 180 190 200
TLLRLERPFL VNVNLPLRPK GFLWTRQSVR AYEGVVIPGE DPMGRPFYWF
210 220 230 240
APRPLKEAEE GTDRWAVAQG FVSATPLRLD LTDETRLQPT LAHD
Length:244
Mass (Da):26,597
Last modified:May 24, 2005 - v1
Checksum:i9D45179793B5F5BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008227 Genomic DNA. Translation: BAD71866.1.
RefSeqiWP_011229220.1. NC_006462.1.
YP_145309.1. NC_006462.1.

Genome annotation databases

EnsemblBacteriaiBAD71866; BAD71866; BAD71866.
GeneIDi3169602.
KEGGittj:TTHB070.
PATRICi23959066. VBITheThe93045_2014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008227 Genomic DNA. Translation: BAD71866.1.
RefSeqiWP_011229220.1. NC_006462.1.
YP_145309.1. NC_006462.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E69X-ray2.20A/B/C/D1-244[»]
2E6BX-ray2.50A/B/C/D1-244[»]
2E6CX-ray2.05A/B/C/D1-244[»]
2E6EX-ray2.50A/B/C/D1-244[»]
2E6GX-ray2.60A/B/C/D/E/F/G/H/I/J/K/L1-244[»]
2E6HX-ray2.10A/B/C/D1-244[»]
ProteinModelPortaliQ53W92.
SMRiQ53W92.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71866; BAD71866; BAD71866.
GeneIDi3169602.
KEGGittj:TTHB070.
PATRICi23959066. VBITheThe93045_2014.

Phylogenomic databases

HOGENOMiHOG000122501.
KOiK03787.
OMAiAITIAHP.
PhylomeDBiQ53W92.

Miscellaneous databases

EvolutionaryTraceiQ53W92.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSURE_THET8
AccessioniPrimary (citable) accession number: Q53W92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.