2-keto-3-deoxy-gluconate kinase - Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Preferred order of sections

Names and origin

Protein names

Submitted name:
2-keto-3-deoxy-gluconate kinase EMBL BAD71875.1

Gene names

Ordered Locus Names:

TTHB079

Encoded on

Plasmid pTT27 EMBL BAD71875.1

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the carbohydrate kinase pfkB family. RuleBase RU003704

Ontologies

Keywords
Ligand	ATP-binding PDB 1V1B Nucleotide-binding
Molecular function	Kinase RuleBase RU003704 SAAS SAAS002173 EMBL BAD71875.1 Transferase
Technical term	3D-structure PDB 1V1B PDB 1V1A PDB 1V1S PDB 1V19 Complete proteome Plasmid EMBL BAD71875.1 Reference proteome
Gene Ontology (GO)
Biological process	D-ribose metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ribokinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

219 – 224

6

ADP PDB 1V1A

Nucleotide binding

219 – 224

6

ATP PDB 1V1B

Nucleotide binding

248 – 250

3

ATP PDB 1V1B

Nucleotide binding

250 – 253

4

ADP PDB 1V1A

Nucleotide binding

275 – 278

4

ADP PDB 1V1A

Nucleotide binding

275 – 278

4

ATP PDB 1V1B

Sites

Binding site

193

1

ATP PDB 1V1B

Binding site

239

1

ATP; via carbonyl oxygen PDB 1V1B

Sequences

Sequence

Length

Mass (Da)

Tools

Q53W83 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: AC817D04B2B0A19B
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FASTA

309

33,430

        10         20         30         40         50         60 
MLEVVTAGEP LVALVPQEPG HLRGKRLLEV YVGGAEVNVA VALARLGVKV GFVGRVGEDE 

        70         80         90        100        110        120 
LGAMVEERLR AEGVDLTHFR RAPGFTGLYL REYLPLGQGR VFYYRKGSAG SALAPGAFDP 

       130        140        150        160        170        180 
DYLEGVRFLH LSGITPALSP EARAFSLWAM EEAKRRGVRV SLDVNYRQTL WSPEEARGFL 

       190        200        210        220        230        240 
ERALPGVDLL FLSEEEAELL FGRVEEALRA LSAPEVVLKR GAKGAWAFVD GRRVEGSAFA 

       250        260        270        280        290        300 
VEAVDPVGAG DAFAAGYLAG AVWGLPVEER LRLANLLGAS VAASRGDHEG APYREDLEVL 


LKATQTFMR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.
[2]	"Structure of Thermus thermophilus 2-Keto-3-deoxygluconate kinase: evidence for recognition of an open chain substrate." Ohshima N., Inagaki E., Yasuike K., Takio K., Tahirov T.H. J. Mol. Biol. 340:477-489(2004) [PubMed: 15210349] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH ADP AND ATP.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AP008227 Genomic DNA. Translation: BAD71875.1.

RefSeq

YP_145318.1. NC_006462.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V19	X-ray	2.30	A/B	1-309	[»]
1V1A	X-ray	2.10	A/B	1-309	[»]
1V1B	X-ray	2.60	A/B/C/D	1-309	[»]
1V1S	X-ray	3.20	A/B/C/D/E/F	1-309	[»]

ProteinModelPortal

Q53W83.

SMR

Q53W83. Positions 1-301.

ModBase

Search...

Protein-protein interaction databases

STRING

Q53W83.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3167896.

GenomeReviews

Gene locus TTHB079 in contig AP008227_GR.

KEGG

ttj:TTHB079.

NMPDR

fig|300852.3.peg.2066.

PATRIC

23959084. VBITheThe93045_2023.

Phylogenomic databases

eggNOG

COG0524.

HOGENOM

HBG697973.

OMA

WAMEEAK.

ProtClustDB

CLSK738238.

Enzyme and pathway databases

BioCyc

TTHE300852:TTHB079-MONOMER.

Family and domain databases

InterPro

IPR011611. Carb/pur_kinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR002139. Ribokinase.
[Graphical view]

KO

K00874.

Pfam

PF00294. PfkB. 1 hit.
[Graphical view]

PRINTS

PR00990. RIBOKINASE.

PROSITE

PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q53W83_THET8

Accession

Primary (citable) accession number: Q53W83

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)