Q53W59 (Q53W59_THET8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cytochrome P450 (Cyp175a1) EMBL BAD71899.1

Gene names

Ordered Locus Names:

TTHB103

Encoded on

Plasmid pTT27 EMBL BAD71899.1

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the cytochrome P450 family. RuleBase RU000461

Ontologies

Keywords
Ligand	Heme RuleBase RU000461 PDB 1WIY Iron Metal-binding
Molecular function	Monooxygenase RuleBase RU003700 Oxidoreductase
Technical term	3D-structure PDB 1WIY Complete proteome Plasmid EMBL BAD71899.1 Reference proteome
Gene Ontology (GO)
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	336	1	Iron (heme axial ligand) PDB 1WIY

Sequences

	Sequence		Length	Mass (Da)
	Q53W59 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: A6F2C742E448B378	FASTA	389	44,229
	10 20 30 40 50 60 MKRLSLREAW PYLKDLQQDP LAVLLEWGRA HPRLFLPLPR FPLALIFDPE GVEGALLAEG 70 80 90 100 110 120 TTKATFQYRA LSRLTGRGLL TDWGKSWKEA RKALKDPFLP KSVRGYREAM EEEAWAFFGE 130 140 150 160 170 180 WRGEERDLDH EMLALSLRLL GRALFGKPLS PSLAEHALKA LDRIMAQTRS PLALLDLAAE 190 200 210 220 230 240 ARFRKDRGAL YREAEALIVH PPLSHLPRER ALSEAVTLLV AGHETVASAL TWSFLLLSHR 250 260 270 280 290 300 PDWQKRVAES EEAALAAFQE ALRLYPPAWI LTRRLERPLL LGEDRLPQGT TLVLSPYVTQ 310 320 330 340 350 360 RLYFPEGEAF QPERFLAERG TPSGRYFPFG LGQRLCLGRD FALLEGPIVL RAFFRRFRLD 370 380 PLPFPRVLAQ VTLRPEGGLP ARPREGVRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.
[2]	"Crystal Structure Analysis of Cytochrome P450 from Thermus thermophilus HB8." Kousumi Y., Nakagawa N., Kaneko M., Yamamoto H., Masui R., Kuramitsu S., Ueyama N. Submitted (MAY-2004) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH HEME.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AP008227 Genomic DNA. Translation: BAD71899.1.

RefSeq

YP_145342.1. NC_006462.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WIY	X-ray	2.00	A/B	1-389	[»]

ProteinModelPortal

Q53W59.

SMR

Q53W59. Positions 1-385.

ModBase

Search...

Protein-protein interaction databases

STRING

Q53W59.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3169232.

GenomeReviews

Gene locus TTHB103 in contig AP008227_GR.

KEGG

ttj:TTHB103.

NMPDR

fig|300852.3.peg.2090.

PATRIC

23959130. VBITheThe93045_2046.

Phylogenomic databases

eggNOG

COG2124.

HOGENOM

HBG569300.

OMA

WALYCLS.

ProtClustDB

CLSK738998.

Enzyme and pathway databases

BioCyc

TTHE300852:TTHB103-MONOMER.

Family and domain databases

InterPro

IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]

Gene3D

G3DSA:1.10.630.10. Cyt_P450. 1 hit.

Pfam

PF00067. p450. 1 hit.
[Graphical view]

PRINTS

PR00463. EP450I.
PR00385. P450.

SUPFAM

SSF48264. Cytochrome_P450. 1 hit.

PROSITE

PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q53W59_THET8

Accession

Primary (citable) accession number: Q53W59

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)