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Q53W52 (Q53W52_THET8) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isopentenyl-diphosphate delta-isomerase HAMAP MF_00354
Short name=IPP isomerase HAMAP MF_00354
EC=5.3.3.2 HAMAP MF_00354
Alternative name(s):
Isopentenyl pyrophosphate isomerase HAMAP MF_00354
Gene names
Name:fni HAMAP MF_00354
Ordered Locus Names:TTHB110
Encoded onPlasmid pTT27 EMBL BAD71906.1
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00354

Catalytic activity

Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP MF_00354

Cofactor

FMN By similarity. HAMAP MF_00354

NADPH By similarity. HAMAP MF_00354

Subcellular location

Cytoplasm By similarity HAMAP MF_00354.

Sequence similarities

Belongs to the IPP isomerase type 2 family. HAMAP MF_00354

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding65 – 673FMN PDB 3DH7
Nucleotide binding187 – 1893FMN PDB 3DH7
Nucleotide binding217 – 2193FMN PDB 3DH7
Nucleotide binding263 – 2664FMN PDB 3DH7
Nucleotide binding285 – 2862FMN PDB 3DH7

Sites

Binding site951FMN; via amide nitrogen PDB 3DH7
Binding site1231FMN PDB 3DH7
Binding site1521FMN PDB 3DH7

Sequences

Sequence LengthMass (Da)Tools
Q53W52 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: E07DA50B0A8C5D92

FASTA33236,019
        10         20         30         40         50         60 
MNIRERKRKH LEACLEGEVA YQKTTTGLEG FRLRYQALAG LALSEVDLTT PFLGKTLKAP 

        70         80         90        100        110        120 
FLIGAMTGGE ENGERINLAL AEAAEALGVG MMLGSGRILL ERPEALRSFR VRKVAPKALL 

       130        140        150        160        170        180 
IANLGLAQLR RYGRDDLLRL VEMLEADALA FHVNPLQEAV QRGDTDFRGL VERLAELLPL 

       190        200        210        220        230        240 
PFPVMVKEVG HGLSREAALA LRDLPLAAVD VAGAGGTSWA RVEEWVRFGE VRHPELCEIG 

       250        260        270        280        290        300 
IPTARAILEV REVLPHLPLV ASGGVYTGTD GAKALALGAD LLAVARPLLR PALEGAERVA 

       310        320        330 
AWIGDYLEEL RTALFAIGAR NPKEARGRVE RV

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Crystal structure of type 2 isopentenyl diphosphate isomerase from Thermus thermophilus in complex with inorganic pyrophosphate."
de Ruyck J., Pouyez J., Rothman S.C., Poulter D., Wouters J.
Biochemistry 47:9051-9053(2008) [PubMed: 18693754] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.97 ANGSTROMS) IN COMPLEX WITH FMN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008227 Genomic DNA. Translation: BAD71906.1.
RefSeqYP_145349.1. NC_006462.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3DH7X-ray2.97A/B/C/D1-332[»]
ProteinModelPortalQ53W52.
SMRQ53W52. Positions 9-332.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ53W52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3169537.
GenomeReviewsGene locus TTHB110 in contig AP008227_GR.
KEGGttj:TTHB110.
NMPDRfig|300852.3.peg.2097.
PATRIC23959144. VBITheThe93045_2053.

Phylogenomic databases

eggNOGCOG1304.
HOGENOMHBG354479.
OMAGSQRAAI.
ProtClustDBPRK05437.

Enzyme and pathway databases

BioCycTTHE300852:TTHB110-MONOMER.

Family and domain databases

HAMAPMF_00354. Idi_2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR011179. IPdP_isomerase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01823.
PANTHERPTHR10578:SF3. IPdP_isomerase. 1 hit.
PfamPF01070. FMN_dh. 2 hits.
[Graphical view]
PIRSFPIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMsTIGR02151. IPP_isom_2. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ53W52_THET8
AccessionPrimary (citable) accession number: Q53W52
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info