Q53W34 (MSRA_THET8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	TTHB132

Encoded on

Plasmid pTT27

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Plasmid Reference proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_0000138604
Sites
	Active site	12	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q53W34 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 699C57ECC9479EE0	FASTA	176	19,872
	10 20 30 40 50 60 MPEEIATLAG GCFWCTEAAF KLLRGVLEVV PGYAGGHVPH PTYEEVCTGT TGHREAVQVR 70 80 90 100 110 120 FDPGVLPYAD LLRYFFAVHD PTSEDRQGPD VGPQYSPAIF YHSEEQKRVA EAVMRELAPL 130 140 150 160 170 YPKPIATKLL PFTTFYPAEA YHRDYFARHP EAPYCRFVIA PKLEKARKAF KSLLRP

References

[1]

"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008227 Genomic DNA. Translation: BAD71928.1.
RefSeq	YP_145371.1. NC_006462.1.
3D structure databases
ProteinModelPortal	Q53W34.
ModBase	Search...
Protein-protein interaction databases
STRING	Q53W34.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3169584.
GenomeReviews	Gene locus TTHB132 in contig AP008227_GR.
KEGG	ttj:TTHB132.
NMPDR	fig|300852.3.peg.2119.
PATRIC	23959192. VBITheThe93045_2077.
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	PYCRFVI.
PhylomeDB	Q53W34.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	TTHE300852:TTHB132-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_THET8

Accession

Primary (citable) accession number: Q53W34

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	May 24, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program