Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q53W24 (Q53W24_THET8) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Glycerol kinase HAMAP MF_00186
EC=2.7.1.30 HAMAP MF_00186
Alternative name(s):
ATP:glycerol 3-phosphotransferase HAMAP MF_00186
Glycerokinase HAMAP MF_00186
Gene names
Name:glpK HAMAP MF_00186
Ordered Locus Names:TTHB142
Encoded onPlasmid pTT27 EMBL BAD71938.1
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186 SAAS SAAS018483

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186 SAAS SAAS018483

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186 SAAS SAAS018483

Sequence similarities

Belongs to the FGGY kinase family. HAMAP MF_00186 RuleBase RU003733

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding407 – 4115ATP By similarity HAMAP MF_00186

Sites

Binding site111Substrate By similarity HAMAP MF_00186
Binding site151ATP By similarity HAMAP MF_00186
Binding site811Substrate By similarity HAMAP MF_00186
Binding site1331Substrate By similarity HAMAP MF_00186
Binding site2421Substrate By similarity HAMAP MF_00186
Binding site2641ATP By similarity HAMAP MF_00186
Binding site3071ATP; via carbonyl oxygen By similarity HAMAP MF_00186

Sequences

Sequence LengthMass (Da)Tools
Q53W24 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 75835CA2628F1E36

FASTA49553,346
        10         20         30         40         50         60 
MAFLLALDQG TTSSRAILFT LEGRPVAVAK REFRQLYPKP GWVEHDPLEI WETTLWAARE 

        70         80         90        100        110        120 
VLRRAGAEAG EVLALGITNQ RETTLLWDRK TGKPLHNAIV WQDRRTTPLC EALRAKGLEP 

       130        140        150        160        170        180 
LFRERTGLLF DPYFSGTKLV WLLENVPGLK ARAEGGGVAF GTVDTWLIWN LTGGKVHATD 

       190        200        210        220        230        240 
PTNASRTLLF NLHTLAWDPE LLEALGIPAA LLPEVRPSDG DFGETLPELL GAPVPIRGVL 

       250        260        270        280        290        300 
GDQQAALFGQ AALGGGEGKC TYGTGAFLLL NTGKRPVLSE KGLLATVAWS LGGRATYALE 

       310        320        330        340        350        360 
GSLFVAGAAV GWLKEVGLIR ESAEVEALAA SVEDTGDVYF VPAFTGLGAP YWDPYARGTL 

       370        380        390        400        410        420 
LGLTRGTSRA HLARAALEGV AFQVRDVVLA MEEEAGVRLK VLKADGGMAQ NRLFLKIQAD 

       430        440        450        460        470        480 
LLGVPVAVPE VTETTALGAA LMAGVGAGAL SPEDVAGRFR EAERFLPTMP EGRREALYRR 

       490 
WREAVERAKG WAREG

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Nucleant-mediated protein crystallization with the application of microporous synthetic zeolites."
Sugahara M., Asada Y., Morikawa Y., Kageyama Y., Kunishima N.
Acta Crystallogr. D Biol. Crystallogr. 64:686-695(2008) [PubMed: 18560157] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008227 Genomic DNA. Translation: BAD71938.1.
RefSeqYP_145381.1. NC_006462.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DPNX-ray2.80A/B1-495[»]
ProteinModelPortalQ53W24.
SMRQ53W24. Positions 3-494.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ53W24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3169247.
GenomeReviewsGene locus TTHB142 in contig AP008227_GR.
KEGGttj:TTHB142.
NMPDRfig|300852.3.peg.2129.
PATRIC23959214. VBITheThe93045_2088.

Phylogenomic databases

eggNOGCOG0554.
HOGENOMHBG511469.
OMASHSAETE.
PhylomeDBQ53W24.

Enzyme and pathway databases

BioCycTTHE300852:TTHB142-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ53W24_THET8
AccessionPrimary (citable) accession number: Q53W24
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info