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Protein

Serine/threonine-protein kinase TAO3

Gene

Taok3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53ATPPROSITE-ProRule annotation1
Active sitei147Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 38ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TAO3 (EC:2.7.11.1)
Alternative name(s):
Axotomy-related gene 357 protein
JNK/SAPK-inhibitory kinase
Jun kinase-inhibitory kinase
Thousand and one amino acid protein 3
Gene namesi
Name:Taok3
Synonyms:Arg357, Jik
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1562861. Taok3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867401 – 898Serine/threonine-protein kinase TAO3Add BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei324PhosphoserineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1
Modified residuei349PhosphoserineCombined sources1
Modified residuei357PhosphothreonineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei442PhosphoserineCombined sources1
Modified residuei830N6-acetyllysineBy similarity1

Post-translational modificationi

Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ53UA7.
PRIDEiQ53UA7.

PTM databases

iPTMnetiQ53UA7.
PhosphoSitePlusiQ53UA7.

Expressioni

Tissue specificityi

Ubiquitously expressed, with a higher expression in the retina.1 Publication

Interactioni

Subunit structurei

Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001503.

Structurei

3D structure databases

ProteinModelPortaliQ53UA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST254

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili452 – 502Sequence analysisAdd BLAST51
Coiled coili548 – 649Sequence analysisAdd BLAST102
Coiled coili753 – 871Sequence analysisAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi326 – 329Poly-Glu4
Compositional biasi390 – 393Poly-Ser4

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0577. Eukaryota.
ENOG410Y259. LUCA.
HOGENOMiHOG000236358.
HOVERGENiHBG088996.
InParanoidiQ53UA7.
KOiK04429.
PhylomeDBiQ53UA7.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53UA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKGVLKDPE IAELFFKEDP EELFIDLHEI GHGSFGAVYF ATNAHTNEVV
60 70 80 90 100
AIKKMSYSGK QTHEKWQDIL KEVRFLQQLK HPNTIEYKGC YLKEHTAWLV
110 120 130 140 150
MEYCLGSASD LLEVHKKPLQ EVEIAAITHG ALQGLAYLHF HSLIHRDIKA
160 170 180 190 200
GNILLTEPGQ VKLADFGSAS MASPANSFVG TPYWMAPEVI LAMDEGQYDG
210 220 230 240 250
KVDIWSLGIT CIELAERKPP LFNMNAMSAL YHIAQNDSPT LQSREWTDSF
260 270 280 290 300
RRFVDYCLHK IPQERPAAAE LLRHDFIRRE RPPRVLIDLI QRTKDAVREL
310 320 330 340 350
DNLQYRKMKK ILFQETRNGP LNESQEEEED SEQGSNLNRE VDSLGSIHSI
360 370 380 390 400
PSVSVSTGSR SSSVNSMQEV MDEGSPELVM MQEDEGTVNS SSSMVHKKDH
410 420 430 440 450
VFVRDEAGHG DPRPEPRPTQ SVQSRALHYR NRERFATIKS ASLVTRQIHE
460 470 480 490 500
HEQENELREQ MSGYKRMRRQ HQKQLIALEN KLKAEMDEHR LKLQKEVETH
510 520 530 540 550
ANNSSIELEK LAKKQVATIE KEAKVAAADE KKFQQQILAQ QKKDLTTFLE
560 570 580 590 600
SQKKQYKICK EKIKEEMNED HSTPKKEKQE RISKHKENLQ HTQAEEEAHL
610 620 630 640 650
LTQQRLYYDR NCRCFKRKIM TKRHEVEQQN IREELNKKRT QKEMEHAMLI
660 670 680 690 700
RHDESTRELE YRQLHTLQKL RMDLIRLQHQ TELENQLEYN KRRERELHRK
710 720 730 740 750
HVMELRQQPK NLKAMEMQIK KQFQDTCKVQ TKQYKALKNH QLEVTPKNEH
760 770 780 790 800
KAILKTLKEE QTRKLAILAE QYEQSINEMM ASQALRLDEA QEAECQALRL
810 820 830 840 850
QLQQEMELLN AYQSKIKMQT EAQHERELQK LEQRVSLRRA HLEQKIEEEL
860 870 880 890
AALQKERSER IKTLLERQER ETETFDMESL RMGFGNLVTL DFPKEDYR
Length:898
Mass (Da):105,474
Last modified:May 24, 2005 - v1
Checksum:i64B140980D0F01AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB195232 mRNA. Translation: BAD97370.1.
RefSeqiNP_001019425.1. NM_001024254.1.
UniGeneiRn.162145.

Genome annotation databases

GeneIDi304530.
KEGGirno:304530.
UCSCiRGD:1562861. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB195232 mRNA. Translation: BAD97370.1.
RefSeqiNP_001019425.1. NM_001024254.1.
UniGeneiRn.162145.

3D structure databases

ProteinModelPortaliQ53UA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001503.

PTM databases

iPTMnetiQ53UA7.
PhosphoSitePlusiQ53UA7.

Proteomic databases

PaxDbiQ53UA7.
PRIDEiQ53UA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi304530.
KEGGirno:304530.
UCSCiRGD:1562861. rat.

Organism-specific databases

CTDi51347.
RGDi1562861. Taok3.

Phylogenomic databases

eggNOGiKOG0577. Eukaryota.
ENOG410Y259. LUCA.
HOGENOMiHOG000236358.
HOVERGENiHBG088996.
InParanoidiQ53UA7.
KOiK04429.
PhylomeDBiQ53UA7.

Miscellaneous databases

PROiQ53UA7.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAOK3_RAT
AccessioniPrimary (citable) accession number: Q53UA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.