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Protein

INO80 complex subunit D

Gene

INO80D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5689603. UCH proteinases.
R-HSA-5696394. DNA Damage Recognition in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
INO80 complex subunit D
Gene namesi
Name:INO80D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000114933.15.
HGNCiHGNC:25997. INO80D.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114933.
PharmGKBiPA162392147.

Polymorphism and mutation databases

BioMutaiINO80D.
DMDMi189045499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195851 – 878INO80 complex subunit DAdd BLAST878

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei132PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ53TQ3.
PaxDbiQ53TQ3.
PeptideAtlasiQ53TQ3.
PRIDEiQ53TQ3.

PTM databases

iPTMnetiQ53TQ3.
PhosphoSitePlusiQ53TQ3.

Expressioni

Gene expression databases

BgeeiENSG00000114933.
CleanExiHS_INO80D.
ExpressionAtlasiQ53TQ3. baseline and differential.
GenevisibleiQ53TQ3. HS.

Organism-specific databases

HPAiHPA043976.

Interactioni

Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.3 Publications

Protein-protein interaction databases

BioGridi120238. 16 interactors.
CORUMiQ53TQ3.
IntActiQ53TQ3. 16 interactors.
STRINGi9606.ENSP00000384198.

Structurei

3D structure databases

ProteinModelPortaliQ53TQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi360 – 363Poly-Asp4

Sequence similaritiesi

Belongs to the INO80D family.Curated

Phylogenomic databases

eggNOGiENOG410IEJY. Eukaryota.
ENOG410XP19. LUCA.
GeneTreeiENSGT00650000093346.
HOVERGENiHBG054165.
InParanoidiQ53TQ3.
KOiK11668.
OMAiHITSPHA.
OrthoDBiEOG091G04C6.
PhylomeDBiQ53TQ3.
TreeFamiTF324169.

Family and domain databases

InterProiView protein in InterPro
IPR025927. Potential_DNA-bd.
PfamiView protein in Pfam
PF13891. zf-C3Hc3H. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53TQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYEGKHIHFS EVDNKPLCSY SPKLCKQRRL NGYAFCIRHV LEDKTAPFKQ
60 70 80 90 100
CEYVAKYNSQ RCTNPIPKSE DRRYCNSHLQ VLGFIPKKER KKKNDPIDEV
110 120 130 140 150
KVRHQMDTMA FSLTVPTLAL KMPNGLDGMS LSPPGARVPL HYLETELEDP
160 170 180 190 200
FAFNEEDDDL KKGATVRKKL QSKLAQNRQR QRETEILKVR QEHFSPPPAP
210 220 230 240 250
SQQQPPQQHS HLSPLSTSLK PPAPPQGSVC KSPQPQNTSL PMQGVAPTTH
260 270 280 290 300
TIAQARQLSH KRPLPLLPSS RAPTVDPPRT DRILMKATAF SPHFSCISRL
310 320 330 340 350
QRLVKLCTQK HQLDTDLFPH LGLDWSEESG EEPEDSEQAS PYQVAWSIRE
360 370 380 390 400
TLRYQRHASD DDDAESRSSR VTQLCTYFQQ KYKHLCRLER AESRQKKCRH
410 420 430 440 450
TFRKALLQAA SKEPECTGQL IQELRRAACS RTSISRTKLR EVEPAACSGT
460 470 480 490 500
VKGEQCANKA LPFTRHCFQH ILLNHSQQLF SSCTAKFADG QQCSVPVFDI
510 520 530 540 550
THQTPLCEEH AKKMDNFLRG DNSRKVQHQQ QRKPRKKTKP PALTKKHKKK
560 570 580 590 600
RRRGPRRPQK PIPPAVPQGN LSMPASVSLP VEASHIRSPS TPELSADELP
610 620 630 640 650
DDIANEITDI PHDLELNQED FSDVLPRLPD DLQDFDFFEG KNGDLLPTTE
660 670 680 690 700
EAEELERALQ AVTSLECLST IGVLAQSDGV PVQELSDRGI GVFSTGTGAS
710 720 730 740 750
GIQSLSREVN TDLGELLNGR IVHDNFSSLE LDENLLRSAT LSNPPTPLAG
760 770 780 790 800
QIQGQFSAPA NVGLTSATLI SQSALGERAF PGQFHGLHDG SHASQRPHPA
810 820 830 840 850
QLLSKADDLI TSRQQYSSDH SHSSPHGSHY DSEHVPSPYS DHITSPHTTS
860 870
YSGDNMAAPV CFRGYHRPAS VAWGLLLN
Length:878
Mass (Da):98,174
Last modified:February 26, 2008 - v2
Checksum:i73CC27B7E1B4799A
GO
Isoform 2 (identifier: Q53TQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     859-878: PVCFRGYHRPASVAWGLLLN → TFSAEMPIMA...NASSPFPSPN

Show »
Length:1,027
Mass (Da):113,202
Checksum:iFC5E886AF361295D
GO

Sequence cautioni

Q53TQ3: The sequence AAH04193 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Q53TQ3: The sequence AAH11687 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Q53TQ3: The sequence AAH11687 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Q53TQ3: The sequence AAH17290 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Q53TQ3: The sequence AAX93069 differs from that shown. Reason: Erroneous gene model prediction.Curated
Q53TQ3: The sequence BAA91079 differs from that shown. Reason: Frameshift at position 513.Curated
Q53TQ3: The sequence BAA91079 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti608T → A in BAG53330 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039012358A → V1 PublicationCorresponds to variant dbSNP:rs2909111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040824859 – 878PVCFR…GLLLN → TFSAEMPIMAQHLLPTQLEV PLGGVVNPRTHWGNLPVNLG DPSPFSNLLGADGHLLSTSL STPPTTSNSETTQPAFATVT PSSSSVLPGLPQTSFSGMGP SAELMASTSPKQQLPQFSAA FGHQLSSHSGIPKDLQPSHS SIAPPTGFTVTGATATSTNN ASSPFPSPN in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096585 mRNA. Translation: BAG53330.1.
AK000316 mRNA. Translation: BAA91079.1. Sequence problems.
AC007383 Genomic DNA. No translation available.
AC007679 Genomic DNA. Translation: AAX93069.1. Sequence problems.
AC092677 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70375.1.
BC004193 mRNA. Translation: AAH04193.2. Sequence problems.
BC011687 mRNA. Translation: AAH11687.1. Sequence problems.
BC017290 mRNA. Translation: AAH17290.2. Sequence problems.
BC136278 mRNA. Translation: AAI36279.1.
CCDSiCCDS46500.1. [Q53TQ3-2]
RefSeqiNP_060229.3. NM_017759.4. [Q53TQ3-2]
XP_011509672.1. XM_011511370.2. [Q53TQ3-2]
XP_011509673.1. XM_011511371.2. [Q53TQ3-2]
XP_011509675.1. XM_011511373.2. [Q53TQ3-2]
XP_011509677.1. XM_011511375.2.
XP_011509678.1. XM_011511376.2.
UniGeneiHs.445036.

Genome annotation databases

EnsembliENST00000403263; ENSP00000384198; ENSG00000114933. [Q53TQ3-2]
ENST00000636453; ENSP00000490850; ENSG00000283510. [Q53TQ3-2]
GeneIDi54891.
KEGGihsa:54891.
UCSCiuc002vaz.4. human. [Q53TQ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIN80D_HUMAN
AccessioniPrimary (citable) accession number: Q53TQ3
Secondary accession number(s): B3KU68
, B9EG77, Q6PJC6, Q6PJU1, Q6PKA1, Q9NXD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 27, 2017
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries