Q53TN4 (CYBR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b reductase 1
EC=1.-.-.-

Alternative name(s):
Duodenal cytochrome b
Ferric-chelate reductase 3

Gene names

Name:	CYBRD1
Synonyms:	DCYTB, FRRS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ferric-chelate reductase that reduces Fe3+ to Fe2+. Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe3+ thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells. Ref.11 Ref.16 Ref.17 Ref.19
Cofactor	Binds 2 heme groups non-covalently By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Ref.8.
Tissue specificity	Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium. Ref.19 Ref.20
Induction	By iron deficiency (at protein level). Ref.8 Ref.18
Polymorphism	Genetic variations in CYBRD1 may act as modifier of iron overload expression and account for the variance observed in serum ferritin levels in patients with hereditary hemochromatosis.
Sequence similarities	Contains 1 cytochrome b561 domain.
Sequence caution	The sequence CAG29366.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAG29367.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Traceable author statement. Source: Reactome electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW response to iron ion Inferred from electronic annotation. Source: Compara transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	brush border membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	ferric-chelate reductase activity Inferred from direct assay PubMed 14499595. Source: HGNC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q53TN4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q53TN4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     66-286: IIVYRLPWTW...LDEAGQRSTM → SFRFFSLSAS...DSHQTAMETS

Note: No experimental confirmation available.

Isoform 3 (identifier: Q53TN4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVFIQGI → MLDEGE

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Cytochrome b reductase 1		PRO_0000314830
Regions
	Transmembrane	12 – 32	21	Helical; Name=1; Potential
	Transmembrane	49 – 69	21	Helical; Name=2; Potential
	Transmembrane	85 – 105	21	Helical; Name=3; Potential
	Transmembrane	123 – 143	21	Helical; Name=4; Potential
	Transmembrane	158 – 178	21	Helical; Name=5; Potential
	Transmembrane	199 – 219	21	Helical; Name=6; Potential
	Domain	15 – 220	206	Cytochrome b561
Sites
	Metal binding	50	1	Iron (heme axial ligand) Potential
	Metal binding	86	1	Iron (heme axial ligand) Potential
	Metal binding	108	1	Iron (heme axial ligand) Potential
	Metal binding	120	1	Iron (heme axial ligand) Potential
	Metal binding	159	1	Iron (heme axial ligand) Potential
Amino acid modifications
	Modified residue	285	1	Phosphothreonine Ref.10 Ref.13 Ref.14
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 64	64	MAMEG…FIQGI → MLDEGE in isoform 3.		VSP_044945
	Alternative sequence	66 – 286	221	IIVYR…QRSTM → SFRFFSLSASMGSAFSPSIS HAHTCLFWNCHLWNSDCNST YGIDRETDFFPERSCIQYIP ARRCFRKYAWPSDPGVRGPH FLDSHQTAMETS in isoform 2.		VSP_042039
	Natural variant	156	1	M → T. Ref.2 Corresponds to variant rs16859487 [ dbSNP | Ensembl ].		VAR_038065
	Natural variant	226	1	R → H in some patients with hereditary hemochromatosis. Ref.7 Ref.15 Corresponds to variant rs62181680 [ dbSNP | Ensembl ].		VAR_038066
	Natural variant	266	1	S → N. Ref.1 Ref.3 Ref.5 Ref.6 Corresponds to variant rs10455 [ dbSNP | Ensembl ].		VAR_038067
Experimental info
	Sequence conflict	7	1	W → R in CAB66628. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 09AA921925A077F7	FASTA	286	31,641
	10 20 30 40 50 60 MAMEGYWRFL ALLGSALLVG FLSVIFALVW VLHYREGLGW DGSALEFNWH PVLMVTGFVF 70 80 90 100 110 120 IQGIAIIVYR LPWTWKCSKL LMKSIHAGLN AVAAILAIIS VVAVFENHNV NNIANMYSLH 130 140 150 160 170 180 SWVGLIAVIC YLLQLLSGFS VFLLPWAPLS LRAFLMPIHV YSGIVIFGTV IATALMGLTE 190 200 210 220 230 240 KLIFSLRDPA YSTFPPEGVF VNTLGLLILV FGALIFWIVT RPQWKRPKEP NSTILHPNGG 250 260 270 280 TEQGARGSMP AYSGNNMDKS DSELNSEVAA RKRNLALDEA GQRSTM
	Isoform 2 [UniParc]. Checksum: 581977048103DD99	FASTA	157	17,903
	10 20 30 40 50 60 MAMEGYWRFL ALLGSALLVG FLSVIFALVW VLHYREGLGW DGSALEFNWH PVLMVTGFVF 70 80 90 100 110 120 IQGIASFRFF SLSASMGSAF SPSISHAHTC LFWNCHLWNS DCNSTYGIDR ETDFFPERSC 130 140 150 IQYIPARRCF RKYAWPSDPG VRGPHFLDSH QTAMETS
	Isoform 3 [UniParc]. Checksum: C97981AD12C20361	FASTA	228	25,087
	10 20 30 40 50 60 MLDEGEAIIV YRLPWTWKCS KLLMKSIHAG LNAVAAILAI ISVVAVFENH NVNNIANMYS 70 80 90 100 110 120 LHSWVGLIAV ICYLLQLLSG FSVFLLPWAP LSLRAFLMPI HVYSGIVIFG TVIATALMGL 130 140 150 160 170 180 TEKLIFSLRD PAYSTFPPEG VFVNTLGLLI LVFGALIFWI VTRPQWKRPK EPNSTILHPN 190 200 210 220 GGTEQGARGS MPAYSGNNMD KSDSELNSEV AARKRNLALD EAGQRSTM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-266. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT THR-156. Tissue: Placenta, Small intestine, Synovium and Trachea.
[3]	NIEHS SNPs program Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-266.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-266.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-266. Tissue: Skin.
[7]	"Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload." Zaahl M.G., Merryweather-Clarke A.T., Kotze M.J., van der Merwe S., Warnich L., Robson K.J.H. Hum. Genet. 115:409-417(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 65-134 AND 187-285, VARIANT HIS-226.
[8]	"Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis." Zoller H., Theurl I., Koch R.O., McKie A.T., Vogel W., Weiss G. Gastroenterology 125:746-754(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INDUCTION.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-285, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis." Constantine C.C., Anderson G.J., Vulpe C.D., McLaren C.E., Bahlo M., Yeap H.L., Gertig D.M., Osborne N.J., Bertalli N.A., Beckman K.B., Chen V., Matak P., McKie A.T., Delatycki M.B., Olynyk J.K., English D.R., Southey M.C., Giles G.G. , Hopper J.L., Allen K.J., Gurrin L.C. Br. J. Haematol. 147:140-149(2009) [PubMed] [Europe PMC] [Abstract] Cited for: POLYMORPHISM, ROLE IN HEREDITARY HEMOCHROMATOSIS.
[12]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-285, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-285, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Gene symbol: DCYTB/CYBRD1. Disease: primary iron overload." Zaahl M.G., Merryweather-Clarke A.T., Kotze M.J., van der Merwe S., Warnich L., Robson K.J. Hum. Genet. 118:546-546(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HIS-226.
[16]	"Gene symbol: DCYTB/CYBRD1. Disease: primary iron overload." Zaahl M.G., Merryweather-Clarke A.T., Kotze M.J., van der Merwe S., Warnich L., Robson K.J. Hum. Genet. 118:548-549(2005) [PubMed] [Europe PMC] [Abstract] Cited for: ROLE IN HEREDITARY HEMOCHROMATOSIS.
[17]	"Gene symbol: DCYTB/CYBRD1. Disease: primary iron overload." Zaahl M.G., Merryweather-Clarke A.T., Kotze M.J., van der Merwe S., Warnich L., Robson K.J. Hum. Genet. 118:549-549(2005) [PubMed] [Europe PMC] [Abstract] Cited for: ROLE IN HEREDITARY HEMOCHROMATOSIS.
[18]	"Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status." Li A.C.Y., Warley A., Thoree V., Simpson R.J., McKie A.T., Kodjabashia K., Thompson R.P.H., Powell J.J. Eur. J. Clin. Invest. 36:890-898(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[19]	"Human erythrocyte membranes contain a cytochrome b561 that may be involved in extracellular ascorbate recycling." Su D., May J.M., Koury M.J., Asard H. J. Biol. Chem. 281:39852-39859(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[20]	"Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells." Turi J.L., Wang X., McKie A.T., Nozik-Grayck E., Mamo L.B., Crissman K., Piantadosi C.A., Ghio A.J. Am. J. Physiol. 291:L272-L280(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136693 mRNA. Translation: CAB66628.1. AK027115 mRNA. Translation: BAB15661.1. AK128495 mRNA. Translation: BAC87466.1. AK291731 mRNA. Translation: BAF84420.1. AK301485 mRNA. Translation: BAG62999.1. AK316588 mRNA. Translation: BAG38176.1. DQ496101 Genomic DNA. Translation: ABF47090.1. AC007969 Genomic DNA. Translation: AAY14730.1. CH471058 Genomic DNA. Translation: EAX11210.1. BC065290 mRNA. Translation: AAH65290.1. AJ715523 Genomic DNA. Translation: CAG29366.1. Sequence problems. AJ715524 Genomic DNA. Translation: CAG29367.1. Sequence problems.
IPI	IPI00100199. IPI00917921.
RefSeq	NP_001120855.1. NM_001127383.1. NP_001243838.1. NM_001256909.1. NP_079119.3. NM_024843.3.
UniGene	Hs.741213.
3D structure databases
ProteinModelPortal	Q53TN4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000319141.
Protein family/group databases
TCDB	5.B.2.1.3. eukaryotic cytochrome b561 (Cytb561) family.
PTM databases
PhosphoSite	Q53TN4.
Polymorphism databases
DMDM	74726934.
Proteomic databases
PaxDb	Q53TN4.
PRIDE	Q53TN4.
Protocols and materials databases
DNASU	79901.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321348; ENSP00000319141; ENSG00000071967. ENST00000375252; ENSP00000364401; ENSG00000071967. ENST00000409484; ENSP00000386739; ENSG00000071967.
GeneID	79901.
KEGG	hsa:79901.
UCSC	uc002ugy.4. human.
Organism-specific databases
CTD	79901.
GeneCards	GC02P172378.
H-InvDB	HIX0002588.
HGNC	HGNC:20797. CYBRD1.
HPA	HPA014757.
MIM	605745. gene.
neXtProt	NX_Q53TN4.
PharmGKB	PA134970061.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG259716.
HOGENOM	HOG000143632.
HOVERGEN	HBG054164.
InParanoid	Q53TN4.
KO	K08370.
OMA	MEGYRGF.
PhylomeDB	Q53TN4.
Enzyme and pathway databases
BioCyc	MetaCyc:HS01046-MONOMER.
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q53TN4.
Bgee	Q53TN4.
CleanEx	HS_CYBRD1.
Genevestigator	Q53TN4.
Family and domain databases
InterPro	IPR006593. Cyt_b561/ferric_Rdtase_TM. IPR004877. Cyt_b561_euk. [Graphical view]
Pfam	PF03188. Cytochrom_B561. 1 hit. [Graphical view]
SMART	SM00665. B561. 1 hit. [Graphical view]
PROSITE	PS50939. CYTOCHROME_B561. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CYBRD1. human.
GenomeRNAi	79901.
NextBio	69747.
SOURCE	Search...

Entry information

Entry name

CYBR1_HUMAN

Accession

Primary (citable) accession number: Q53TN4
Secondary accession number(s): B2RE79 , B4DWD7, Q6KC16, Q6KC17, Q6P147, Q6ZR51, Q9H0Q8, Q9H5G5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 24, 2005
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.