Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Uncharacterized protein ITSN2

Gene

ITSN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi66 – 77PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized protein ITSN2Imported
Gene namesi
Name:ITSN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiQ53TK4.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ53TK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 109EHInterPro annotationAdd BLAST89
Domaini53 – 88EF-handInterPro annotationAdd BLAST36
Domaini243 – 332EHInterPro annotationAdd BLAST90
Domaini276 – 311EF-handInterPro annotationAdd BLAST36
Domaini756 – 817SH3InterPro annotationAdd BLAST62
Domaini897 – 955SH3InterPro annotationAdd BLAST59
Domaini980 – 1038SH3InterPro annotationAdd BLAST59
Domaini1052 – 1116SH3InterPro annotationAdd BLAST65
Domaini1126 – 1185SH3InterPro annotationAdd BLAST60
Domaini1208 – 1329DHInterPro annotationAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili367 – 500Sequence analysisAdd BLAST134
Coiled coili508 – 549Sequence analysisAdd BLAST42
Coiled coili584 – 618Sequence analysisAdd BLAST35
Coiled coili646 – 691Sequence analysisAdd BLAST46
Coiled coili704 – 753Sequence analysisAdd BLAST50

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
HOVERGENiHBG052159.

Family and domain databases

CDDicd00160. RhoGEF. 1 hit.
cd11988. SH3_Intersectin2_1. 1 hit.
cd11990. SH3_Intersectin2_2. 1 hit.
cd11992. SH3_Intersectin2_3. 1 hit.
cd11994. SH3_Intersectin2_4. 1 hit.
cd11996. SH3_Intersectin2_5. 1 hit.
Gene3Di1.20.900.10. 1 hit.
InterProiView protein in InterPro
IPR035899. DBL_dom_sf.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR035737. Intersectin-2_SH3_1.
IPR035738. Intersectin-2_SH3_2.
IPR035739. Intersectin-2_SH3_3.
IPR035740. Intersectin-2_SH3_4.
IPR035741. Intersectin-2_SH3_5.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 4 hits.
PfamiView protein in Pfam
PF12763. EF-hand_4. 2 hits.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 5 hits.
PROSITEiView protein in PROSITE
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50002. SH3. 5 hits.

Sequencei

Sequence statusi: Fragment.

Q53TK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFPTAMNG GPNMWAITSE ERTKHDRQFD NLKPSGGYIT GDQARNFFLQ
60 70 80 90 100
SGLPAPVLAE IWALSDLNKD GKMDQQEFSI AMKLIKLKLQ GQQLPVVLPP
110 120 130 140 150
IMKQPPMFSP LISARFGMGS MPNLSIPQPL PPAAPITSLS SATSGTNLPP
160 170 180 190 200
LMMPTPLVPS VSTSSLPNGT ASLIQPLPIP YSSSTLPHGS SYSLMMGGFG
210 220 230 240 250
GASIQKAQSL IDLGSSSSTS STASLSGNSP KTGTSEWAVP QPTRLKYRQK
260 270 280 290 300
FNTLDKSMSG YLSGFQARNA LLQSNLSQTQ LATIWTLADV DGDGQLKAEE
310 320 330 340 350
FILAMHLTDM AKAGQPLPLT LPPELVPPSF RGGKQIDSIN GTLPSYQKMQ
360 370 380 390 400
EEEPQKKLPV TFEDKRKANY ERGNMELEKR RQALMEQQQR EAERKAQKEK
410 420 430 440 450
EEWERKQREL QEQEWKKQLE LEKRLEKQRE LERQREEERR KDIERREAAK
460 470 480 490 500
QELERQRRLE WERIRRQELL NQKNREQEEI VRLNSKKKNL HLELEALNGK
510 520 530 540 550
HQQISGRLQD VRLKKQTQKT ELEVLDKQCD LEIMEIKQLQ QELQEYQNKL
560 570 580 590 600
IYLVPEKQLL NERIKNMQFS NTPDSGVSLL HKKSLEKEEL CQRLKEQLDA
610 620 630 640 650
LEKETASKLS EMDSFNNQLK CGNMDDSVLQ CLLSLLSCLN NLFLLLKELR
660 670 680 690 700
ETYNTQQLAL EQLYKIKRDK LKEIERKRLE LMQKKKLEDE AARKAKQGKE
710 720 730 740 750
NLWKENLRKE EEEKQKRLQE EKTQEKIQEE ERKAEEKQRK DKDTLKAEEK
760 770 780 790 800
KRETASVLVN YRALYPFEAR NHDEMSFNSG DIIQVDEKTV GEPGWLYGSF
810 820 830 840 850
QGNFGWFPCN YVEKMPSSEN EKAVSPKKAL LPPTVSLSAT STSSEPLSSN
860 870 880 890 900
QPASVTDYQN VSFSNLTVNT SWQKKSAFTR TVSPGSVSPI HGQGQVVENL
910 920 930 940 950
KAQALCSWTA KKDNHLNFSK HDIITVLEQQ ENWWFGEVHG GRGWFPKSYV
960 970 980 990 1000
KIIPGSEVKR EEPEALYAAV NKKPTSAAYS VGEEYIALYP YSSVEPGDLT
1010 1020 1030 1040 1050
FTEGEEILVT QKDGEWWTGS IGDRSGIFPS NYVKPKDQES FGSASKSGAS
1060 1070 1080 1090 1100
NKKPEIAQVT SAYVASGSEQ LSLAPGQLIL ILKKNTSGWW QGELQARGKK
1110 1120 1130 1140 1150
RQKGWFPASH VKLLGPSSER ATPAFHPVCQ VIAMYDYAAN NEDELSFSKG
1160 1170 1180 1190 1200
QLINVMNKDD PDWWQGEING VTGLFPSNYV KMTTDSDPSQ QWCADLQTLD
1210 1220 1230 1240 1250
TMQPIERKRQ GYIHELIQTE ERYMADLQLV VEVFQKRMAE SGFLTEGEMA
1260 1270 1280 1290 1300
LIFVNWKELI MSNTKLLKAL RVRKKTGGEK MPVQMIGDIL AAELSHMQAY
1310 1320
IRFCSCQLNG AALLQQKTDE DTDFKEFLK
Length:1,329
Mass (Da):151,016
Last modified:May 24, 2005 - v1
Checksum:i4A87D0F1521C0C67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1329Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009228 Genomic DNA. Translation: AAX93122.1.
UniGeneiHs.432562.

Similar proteinsi

Entry informationi

Entry nameiQ53TK4_HUMAN
AccessioniPrimary (citable) accession number: Q53TK4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: January 31, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation