ID   Q53TH5_HUMAN            Unreviewed;       290 AA.
AC   Q53TH5;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   24-JAN-2024, entry version 64.
DE   RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083};
DE   Flags: Fragment;
GN   Name=ORC4L {ECO:0000313|EMBL:AAX93051.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAX93051.1};
RN   [1] {ECO:0000313|EMBL:AAX93051.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Lamar B., Drone K., LaPlant Y., Gibson A.;
RT   "The sequence of Homo sapiens BAC clone RP11-295N18.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAX93051.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Waterston R.H.;
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAX93051.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Waterston R.;
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAX93051.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ORC4 family.
CC       {ECO:0000256|ARBA:ARBA00005334}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC009480; AAX93051.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q53TH5; -.
DR   PeptideAtlas; Q53TH5; -.
DR   ChiTaRS; ORC4; human.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR016527; ORC4.
DR   InterPro; IPR032705; ORC4_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR   PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR   Pfam; PF14629; ORC4_C; 1.
DR   PIRSF; PIRSF007858; ORC4; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          82..269
FT                   /note="Origin recognition complex subunit 4 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14629"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAX93051.1"
SQ   SEQUENCE   290 AA;  33935 MW;  46C58CF595223037 CRC64;
     DRTSSCPVIF ILDEFDLFAH HKNQTLLYNL FDISQSAQTP IAVIGLTCRL DILELLEKRV
     KSRFSHRQIH LMNSFGFPQY VKIFKEQLSL PAEFPDKVFA EKWNENVQYL SEDRSVQEVL
     QKHFNISKNL RSLHMLLMLA LNRVTASHPF MTAVDLMEAS QLCSMDSKAN IVHGLSVLEI
     CLIIAMKHLN DIYEEEPFNF QMVYNEFQKF VQRKAHSVYN FEKPVVMKAF EHLQQLELIK
     PMERTSGNSQ REYQLMKLLL DNTQIMNALQ KYPNCPTDVR QWATSSLSWL
//