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Protein

Receptor protein-tyrosine kinase

Gene

EPHA4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinaseSAAS annotation, ReceptorSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:EPHA4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei273 – 295HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ53TA0.
PeptideAtlasiQ53TA0.

Structurei

3D structure databases

ProteinModelPortaliQ53TA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 164Fibronectin type-IIIInterPro annotationAdd BLAST112
Domaini165 – 262Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini346 – 607Protein kinaseInterPro annotationAdd BLAST262
Domaini636 – 700SAMInterPro annotationAdd BLAST65

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG062180.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR027936. Eph_TM.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed_sf.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF14575. EphA2_TM. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00060. FN3. 2 hits.
SM00220. S_TKc. 1 hit.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q53TA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CKIGYYKALS TDATCAKCPP HSYSVWEGAT SCTCDRGFFR ADNDAASMPC
60 70 80 90 100
TRPPSAPLNL ISNVNETSVN LEWSSPQNTG GRQDISYNVV CKKCGAGDPS
110 120 130 140 150
KCRPCGSGVH YTPQQNGLKT TKVSITDLLA HTNYTFEIWA VNGVSKYNPN
160 170 180 190 200
PDQSVSVTVT TNQAAPSSIA LVQAKEVTRY SVALAWLEPD RPNGVILEYE
210 220 230 240 250
VKYYEKDQNE RSYRIVRTAA RNTDIKGLNP LTSYVFHVRA RTAAGYGDFS
260 270 280 290 300
EPLEVTTNTV PSRIIGDGAN STVLLVSVSG SVVLVVILIA AFVISRRRSK
310 320 330 340 350
YSKAKQEADE EKHLNQGVRT YVDPFTYEDP NQAVREFAKE IDASCIKIEK
360 370 380 390 400
VIGVGEFGEV CSGRLKVPGK REICVAIKTL KAGYTDKQRR DFLSEASIMG
410 420 430 440 450
QFDHPNIIHL EGVVTKCKPV MIITEYMENG SLDAFLRKND GRFTVIQLVG
460 470 480 490 500
MLRGIGSGMK YLSDMSYVHR DLAARNILVN SNLVCKVSDF GMSRVLEDDP
510 520 530 540 550
EAAYTTRGGK IPIRWTAPEA IAYRKFTSAS DVWSYGIVMW EVMSYGERPY
560 570 580 590 600
WDMSNQDVIK AIEEGYRLPP PMDCPIALHQ LMLDCWQKER SDRPKFGQIV
610 620 630 640 650
NMLDKLIRNP NSLKRTGTES SRPNTALLDP SSPEFSAVVS VGDWLQAIKM
660 670 680 690 700
DRYKDNFTAA GYTTLEAVVH VNQEDLARIG ITAITHQNKI LSSVQAMRTQ
710
MQQMHGRMVP V
Length:711
Mass (Da):79,020
Last modified:May 24, 2005 - v1
Checksum:i07D810812E2096DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010899 Genomic DNA. Translation: AAY24284.1.
UniGeneiHs.371218.

Similar proteinsi

Entry informationi

Entry nameiQ53TA0_HUMAN
AccessioniPrimary (citable) accession number: Q53TA0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.