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Protein
Submitted name:

Putative uncharacterized protein TCF7L1

Gene

TCF7L1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. anterior/posterior axis specification, embryo Source: Ensembl
  2. axial mesoderm morphogenesis Source: Ensembl
  3. canonical Wnt signaling pathway Source: InterPro
  4. negative regulation of transcription, DNA-templated Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter during mitosis Source: Ensembl
  6. regulation of stem cell maintenance Source: Ensembl
  7. skin development Source: Ensembl
  8. somatic stem cell maintenance Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized protein TCF7L1Imported
Gene namesi
Name:TCF7L1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ53T87.
ExpressionAtlasiQ53T87. baseline and differential.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000419.

Family and domain databases

Gene3Di4.10.900.10. 1 hit.
InterProiIPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR024940. TCF/LEF.
IPR028778. Tcf7l1.
[Graphical view]
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF25. PTHR10373:SF25. 1 hit.
PfamiPF08347. CTNNB1_binding. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q53T87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLGGGGGG GGGGSGGGGG SSAGAAGGGD DLGANDELIP FQDEGGEEQE
60 70 80 90 100
PSSDSASAQR DLDEVKSSLV NESENQSSSS DSEAERRPQP VRDTFQKPRD
110 120 130 140
YFAEVRRPQD SAFFKGPPYP GYPFLMIPDL SSPYLSNGPL SPGGART
Length:147
Mass (Da):15,026
Last modified:May 24, 2005 - v1
Checksum:i3ACCACFCCA1F6F0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei147 – 1471Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011236 Genomic DNA. Translation: AAY15068.1.
UniGeneiHs.516297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011236 Genomic DNA. Translation: AAY15068.1.
UniGeneiHs.516297.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000419.

Miscellaneous databases

ChiTaRSiTCF7L1. human.

Gene expression databases

BgeeiQ53T87.
ExpressionAtlasiQ53T87. baseline and differential.

Family and domain databases

Gene3Di4.10.900.10. 1 hit.
InterProiIPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR024940. TCF/LEF.
IPR028778. Tcf7l1.
[Graphical view]
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF25. PTHR10373:SF25. 1 hit.
PfamiPF08347. CTNNB1_binding. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of Homo sapiens BAC clone RP11-312D1."
    Abbott A., Holmes A., Boyer E.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Waterston R.H.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Waterston R.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Wilson R.K.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ53T87_HUMAN
AccessioniPrimary (citable) accession number: Q53T87
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.