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Protein
Submitted name:

Cell growth-inhibiting gene 8

Gene

ID2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cell growth-inhibiting gene 8Imported
Submitted name:
Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, isoform CRA_aImported
Submitted name:
Putative uncharacterized protein ID2Imported
Submitted name:
cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNAImported
Gene namesi
Name:ID2Imported
Synonyms:GIG8Imported
ORF Names:hCG_1784377Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29609.

Expressioni

Gene expression databases

BgeeiENSG00000115738.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000234091.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 75BHLH (basic helix-loop-helix)InterPro annotationAdd BLAST53

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IVXR. Eukaryota.
ENOG4111PGK. LUCA.
HOVERGENiHBG009009.
KOiK17693.
OMAiFPSEFMS.
OrthoDBiEOG091G0VHR.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERiPTHR11723. PTHR11723. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53T66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV
60 70 80 90 100
PSIPQNKKVS KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR
110 120 130
TPLTTLNTDI SILSLQASEF PSELMSNDSK ALCG
Length:134
Mass (Da):14,917
Last modified:May 24, 2005 - v1
Checksum:iA0D98B96396EB11E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY634687 mRNA. Translation: AAV35470.1.
AC011747 Genomic DNA. Translation: AAY14810.1.
AK311988 mRNA. Translation: BAG34927.1.
CH471053 Genomic DNA. Translation: EAX01018.1.
CH471053 Genomic DNA. Translation: EAX01019.1.
RefSeqiNP_002157.2. NM_002166.4.
UniGeneiHs.180919.
Hs.726053.

Genome annotation databases

GeneIDi3398.
KEGGihsa:3398.
UCSCiuc002qza.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY634687 mRNA. Translation: AAV35470.1.
AC011747 Genomic DNA. Translation: AAY14810.1.
AK311988 mRNA. Translation: BAG34927.1.
CH471053 Genomic DNA. Translation: EAX01018.1.
CH471053 Genomic DNA. Translation: EAX01019.1.
RefSeqiNP_002157.2. NM_002166.4.
UniGeneiHs.180919.
Hs.726053.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000234091.

Protocols and materials databases

DNASUi3398.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3398.
KEGGihsa:3398.
UCSCiuc002qza.4. human.

Organism-specific databases

CTDi3398.
PharmGKBiPA29609.

Phylogenomic databases

eggNOGiENOG410IVXR. Eukaryota.
ENOG4111PGK. LUCA.
HOVERGENiHBG009009.
KOiK17693.
OMAiFPSEFMS.
OrthoDBiEOG091G0VHR.

Miscellaneous databases

GenomeRNAii3398.

Gene expression databases

BgeeiENSG00000115738.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR026052. DNA-bd_prot-inh.
[Graphical view]
PANTHERiPTHR11723. PTHR11723. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53T66_HUMAN
AccessioniPrimary (citable) accession number: Q53T66
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.